YDL223C (HBT1) mai ƙera foda Lambar CAS: 489408-02-8 Tsarkakakken kashi 99% na mintuna don ƙarin sinadaran

HBT1 yana ɗaurewa da yankin ɗaurewar ligand na mai karɓar acid na α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA-R) ta hanyar da ta dogara da glutamate. Wannan yana nufin cewa HBT1 kwayar halitta ce da za ta iya ɗaurewa zuwa wani takamaiman wuri akan furotin AMPA-R kawai lokacin da glutamate yake, kuma wannan ɗaurewar tana taimakawa wajen daidaita ayyukan furotin. Ana bayyana masu karɓar AMPA a cikin tsarin juyayi na tsakiya kuma suna taka muhimmiyar rawa a cikin sadarwa ta jijiyoyi, sarrafa ji, koyo, ƙwaƙwalwa, da kuma plasticity na synaptic. Masu karɓar AMPA manyan masu ba da gudummawa ne ga watsawar jijiyoyi, suna shiga tsakani cikin sauri, da sauri rage jin daɗi a yawancin synapses, kuma suna da hannu a cikin martanin farko ga glutamate a yankunan synaptic. Sau da yawa ana nuna masu karɓar AMPA tare da masu karɓar NMDA a synapses, kuma tare suna haɓaka hanyoyin plasticity na synaptic da ke da hannu a koyo, ƙwaƙwalwa, gubar excitotoxicity, da karewar neuroprotection. Kwakwalwa ta hanyar neurotrophic factor (BDNF) wani abu ne mai haifar da neurotrophic wanda ke taka muhimmiyar rawa wajen kiyayewa da faɗaɗa ƙwayoyin jijiyoyi kuma yana da tasiri mai ƙarfi da yawa akan yaduwa, bambance-bambance, rayuwa da mutuwar ƙwayoyin jijiyoyi da waɗanda ba na jijiyoyi ba. , wani mai daidaita neurotransmitter wanda ke ba da gudummawa ga ƙarfin jijiyoyi a cikin koyo da ƙwaƙwalwa. Saboda haka, yana da mahimmanci ga lafiya da walwalar tsarin jijiyoyi.