Tsufa wani tsari ne na halitta wanda babu makawa na rayayyun halittu, wanda ke bayyana da raguwar tsarin jiki da aiki na tsawon lokaci. Wannan tsari yana da rikitarwa kuma yana da saurin kamuwa da tasiri mai zurfi daga abubuwa daban-daban na waje kamar yanayi. Don fahimtar saurin tsufa daidai, masana kimiyya sun yi watsi da tsarin ma'auni na gargajiya na shekaru ko kwanaki kuma a maimakon haka sun mai da hankali kan mafi ƙayyadaddun lokaci, suna ƙoƙarin samun fahimtar dabarar tsarin tsufa.
A cikin wannan binciken, masana kimiyya sun ƙirƙiri jerin tsofaffin ƙwayoyin halitta tare da hazaka, daga cikinsu samfuran methylation na DNA suna ɗaukar ido musamman. A matsayin maɓalli na tsarin tsarin tsarin halitta, tsarin DNA methylation na iya yin taswirar daidaitaccen bayanin martabar mutum na yanzu, ba wai kawai yana bayyana sauye-sauyen canje-canje na bayanan kwayoyin halitta a cikin tsarin tsufa ba, har ma ya zama wajibi a binciken kimiyyar tsufa. madaidaicin kayan aikin. Ta hanyar zurfafa bincike na waɗannan alamomin halittu, masana kimiyya za su iya samun hangen nesa na hanyoyin ƙwayoyin cuta a bayan tsufa, buɗe sabbin hanyoyi don jinkirta tsufa da haɓaka tsufa.
A cikin sararin samaniyar taurarin kimiyyar rigakafin tsufa, NMN (nicotinamide mononucleotide) ya taɓa yawo a sararin sama kamar meteor mai ban mamaki. Asalin sa a matsayin mafarin NAD + (nicotinamide adenine dinucleotide) ya ƙarfafa masana kimiyya marasa adadi. sha'awar bincike. Duk da haka, tare da wucewar lokaci, wani tauraro mai haske, AKG (alpha-ketoglutarate), a hankali ya fito kuma ya sami karbuwa mai yawa a fagen rigakafin tsufa tare da fara'a na musamman da tushen kimiyya. .
A cikin wani binciken da aka buga a cikin mujallar Nature Metabolism, masana kimiyya sun yi karin bayani game da tsarin AKG a cikin makamashin makamashi, aikin mitochondrial da anti-tsufa. Binciken ya nuna cewa AKG na iya haɓaka zagayowar tricarboxylic acid kai tsaye da kuma ƙara yawan fitarwar kuzari a cikin sel, don haka haɓaka haɓakar sel gaba ɗaya. Bugu da ƙari, mujallar "Cell Metabolism" ta kuma buga sakamakon bincike game da ikon AKG na inganta haɓakar collagen da inganta elasticity na fata, yana ƙara tabbatar da yiwuwarsa a fagen rigakafin tsufa.
Juya alamun lokaci
Wani bincike na asibiti daga Japan ya ba mu misali mai haske. Wata mata mai matsakaicin shekaru wacce ta dade tana mai da hankali kan hana tsufa, bayan ta sha maganin AKG tsawon rabin shekara, ba wai yanayin fatarta kadai ya inganta ba, ta kara karfi da karfin jiki, amma gaba daya lafiyar jikinta. haka kuma an inganta yanayin tunani sosai. Ta hanyar kwatanta alamomin ilimin halittar jiki kafin da kuma bayan gwajin, masu binciken sun gano cewa aikin mitochondrial na mace ya inganta sosai, wanda ke da alaƙa da rawar AKG na haɓaka haɓakar kuzari.
Mai gadin lafiyar jijiyoyin jiki
Wani binciken daga Amurka ya mayar da hankali kan aikin neuroprotective na AKG. Bayan karbar magani na AKG, wani dattijo da ke da raunin hankali ya nuna gagarumin ci gaba a cikin iyawar fahimtarsa, ciki har da ingantaccen ƙwaƙwalwar ajiya da maida hankali. Masu binciken sun lura ta hanyar fasahar hoto ta kwakwalwa cewa an dawo da aikin mitochondrial na mai haƙuri, wanda ke ba da goyon baya mai ƙarfi ga AKG wajen hanawa da kuma magance cututtukan neurodegenerative.
fa'idodin AKG na musamman
1. Multi-girma anti-tsufa sakamako
Ba kamar NMN ba, wanda galibi yaƙar tsufa ta hanyar haɓaka matakan NAD +, AKG yana taka rawar gani sosai a cikin rigakafin tsufa. Ba wai kawai yana haɓaka haɓakar kuzarin kuzari da haɓaka aikin mitochondrial ba, har ma yana haɓaka yanayin tsufa na jiki daga nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan nau'ikan haɓakar haɓakar haɓaka haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar ƙwayoyin cuta da haɓaka haɓakar ƙwayoyin cuta.
2. Higher biocompatibility da aminci
A matsayin metabolite da ke faruwa a zahiri na jikin ɗan adam, AKG yana da kyakkyawan daidaituwa da aminci. Za a iya shafe shi kai tsaye kuma a yi amfani da shi ta jikin ɗan adam ba tare da tafiya ta hanyar juzu'i mai rikitarwa ba, rage haɗarin yiwuwar mummunan halayen. Wannan ya sa aikace-aikacen AKG a cikin filin rigakafin tsufa ya fi aminci kuma mafi aminci.
3. Fa'idodin kiwon lafiya da yawa
Baya ga rigakafin tsufa, AKG kuma yana nuna fa'idodin kiwon lafiya da yawa don haɓaka lafiyar jijiyoyin jiki da haɓaka rigakafi. Waɗannan ƙarin fa'idodin kiwon lafiya sun sa AKG ya fi kyau don aikace-aikacen rigakafin tsufa.
Tare da ci gaba da zurfafa bincike na kimiyya da ci gaba da ci gaban fasaha, buƙatun aikace-aikacen AKG a fagen rigakafin tsufa za su fi girma. Muna sa ran samun ƙarin bincike mai inganci a nan gaba don bayyana ƙarin asirin AKG, sannan kuma muna sa ran za a iya haɗa shi da sauran dabarun yaƙi da tsufa kamar NMN don ba da gudummawar hikima da ƙarfi ga lafiyar ɗan adam da tsawon rai. . A cikin wannan tsere da lokaci, AKG babu shakka ya nuna gasa mai ƙarfi da yuwuwar mara iyaka.
Babban ayyuka sune:
Anti-tsufa: Yana iya jinkirta tsarin tsufa na salon salula ta hanyar daidaita hanyar siginar mTOR, haɓaka autophagy, inganta haɓakar ƙwayoyin cuta na furotin, da daidaita tsarin epigenetics. Bugu da ƙari, yana iya inganta haɓakar collagen, tallafawa detoxification na cell, taimakawa mayar da matakan maida hankali na calcium na al'ada a cikin jini, hanzarta warkar da raunuka, inganta gyaran ƙwayar tsoka, da dai sauransu.
Inganta cututtuka na yau da kullum: Gwaje-gwaje na asibiti sun nuna cewa yana da tasiri mai mahimmanci akan cututtuka daban-daban, ciki har da amma ba'a iyakance ga osteoporosis ba, cututtukan neurodegenerative (irin su cutar Parkinson), cututtuka na zuciya da jijiyoyin jini, ciwon sukari, da ciwon daji. Yana magance tushen tushen cututtuka na yau da kullun ta hanyar kunna sunadaran tsawon rayuwa a cikin jiki da gyara DNA da suka lalace.
Inganta rigakafi: Yana iya haɓaka aiki da adadin ƙwayoyin rigakafi, inganta garkuwar jiki gabaɗaya, don haka yana taimakawa jiki ya fi tsayayya da cututtuka da cututtuka.
Haɓaka lafiya: Wannan samfurin kuma yana da fa'idodi kamar haɓaka metabolism na sukari da kitse a cikin jiki da tallafawa aikin fahintar kwakwalwa lafiya, yana taimakawa wajen kiyaye lafiyar jikin ɗan adam gabaɗaya.
Abubuwan rigakafin tsufa suna samun goyan bayan binciken kimiyya. Alal misali, a cikin 2014, babban jaridar "Nature" ya ruwaito a karon farko cewa za a iya jinkirta tsufa ta hanyar hana ayyukan mTOR; bincike kan ƙwayoyin osteosarcoma na ɗan adam ya kuma tabbatar da cewa zai iya inganta autophagy; Bugu da ƙari, yana iya shiga cikin haɗin amino acid kuma yana rage yawan furotin. Abubuwan da ba su da kyau suna faruwa kuma suna shiga cikin tsarin tsarin tsarin epigenetic kamar demethylation na DNA.
Gwaje-gwaje na asibiti sun kara tabbatar da amincinsa da ingancinsa. Misali, rahoton gwaji na asibiti na Phase I wanda Asibitin NewMed a California ya ba da izini ya nuna cewa yana da tasirin warkewa ga nau'ikan cututtukan cututtuka daban-daban kamar rashin bacci, asarar ƙwaƙwalwar ajiya, gazawar koda, ciwon bugun jini, kuma yana iya magance gajeriyar cututtuka. numfashi, gajiya, da sauran alamomin da sabon coronavirus ke haifarwa. Har ila yau, yana da kyakkyawan sakamako na kwantar da hankali akan abubuwan da ke faruwa kamar tari.
Tare da ingantaccen inganci da aminci, ya sami yabo sosai a kasuwa. Yawancin masu amfani sun ba da rahoton ci gaba mai mahimmanci a cikin yanayin jikinsu bayan shan shi, kamar ƙarin ƙarfi, ƙarfi da ƙarin fata mai laushi, da sauransu. A lokaci guda, wannan samfurin kuma an gane shi kuma yana goyan bayan yawancin cibiyoyi da masana masu iko.
Don taƙaitawa, Calcium Alpha ketoglutarate samfurin kimiyya ne, lafiyayye da inganci na rigakafin tsufa. Yana samun tasirin maganin tsufa kuma yana inganta alamun cututtukan cututtuka daban-daban ta hanyoyi da yawa. Yana da kyakkyawan zaɓi ga mutanen da ke bin lafiya da tsawon rai.
Lokacin aikawa: Jul-08-2024
