Mahalli na halitta suna cikin ƙara buƙata a cikin binciken kimiyya na yau da masana'antar harhada magunguna. 7,8-Dihydroxyflavone (7,8-Dihydroxyflavone), a matsayin wani muhimmin fili wanda aka samo daga shuka, ya jawo hankalin tartsatsi saboda mahimmancin ayyukan ilimin halitta. Ga masu binciken kimiyya da kamfanoni, yana da mahimmanci don nemo masu samar da abin dogaro na 7,8-Dihydroxyflavone Foda. 7,8-Dihydroxyflavone Foda wanda Suzhou Myland ya bayar yana dalambar CAS na 38183-03-8 da tsabta har zuwa 98%, samar muku da zabi mai aminci.
7,8-Dihydroxyflavone(wanda kuma aka sani da 7,8-DHF ko proflavonoid) kwayoyin halitta ne na halitta wanda ke cikin nau'in flavonoid na mahadi. An samo shi a cikin ganyen Godmania aesculifolia, Tridax procumbens da primula.
7,8-DHF wani fili ne na kwayoyin halitta tare da tsarin kwayoyin C15H10O4. Yana da narkewa a cikin kaushi na halitta kuma yana da halayyar launi, wari da dandano da ke hade da mahadi na flavonoid.
7,8-DHF ya fito a matsayin fili mai ban sha'awa na nootropic. Ya nuna nau'in tasirin neuropharmacological a cikin binciken da ya dace, ciki har da inganta ƙwaƙwalwar ajiya, inganta neurogenesis da hana neurodegeneration.
A matsayin mai ƙarfi da zaɓin ƙananan ƙwayoyin ƙwayoyin cuta na tropomyosin receptor kinase B (TrkB), proflavin ya nuna inganci a cikin samfuran dabbobi akan cututtuka daban-daban, gami da cutar Alzheimer.
Flavonoids wani nau'in mahadi ne na polyphenolic da ake samu a cikin 'ya'yan itatuwa, kayan lambu, da sauran tushen shuka iri-iri. A cikin 'yan shekarun nan, sun sami kulawa mai yawa saboda antioxidant, anti-inflammatory, da neuroprotective Properties.
An nuna waɗannan mahadi don samun tasiri mai amfani akan kwakwalwa, ciki har da haɓaka aikin fahimi da hana cututtukan neurodegenerative. 7,8-DHF shine ɗayan shahararrun mahaɗan polyphenolic waɗanda ke karɓar ƙarin hankali azaman nootropic. An yi nazarinsa don yuwuwar tasirinsa akan yanayi, ƙwaƙwalwa, koyo, damuwa, da sauran ayyukan fahimi.
Abubuwan da ke tattare da ƙwayoyin cuta na 7,8-DHF ana tsammanin za su shiga tsakani ta hanyar hulɗar ta tare da takamaiman masu karɓa. An samo shi a matsayin TrkA, mai karɓa wanda ke da hannu a cikin siginar haɓakar jijiyoyi kuma yana da mahimmanci ga rayuwar neuronal da filastik.
7,8-DHF yana aiki ta hanyar daidaita maganganun masu karɓa daban-daban, ciki har da subunits masu karɓa na glutamate da BDNF. Hakanan yana rinjayar samuwar synapse, makamashin makamashi, da sakin acetylcholine a wasu sassan kwakwalwa.
Bincike akan 7,8-dihydroxyflavone ya faɗaɗa cikin tasirinsa akan lafiyar ɗan adam, musamman kallon yadda yake kwaikwayi ayyukan ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa (BDNF), furotin mai mahimmanci don rayuwa da aiki na neuronal. na gina jiki.
Dangane da amfani da shi, an bincika 7,8-DHF don aikace-aikacen da za a iya amfani da su a cikin maganin cututtuka na jijiyoyi saboda ikonsa na shiga cikin shingen kwakwalwar jini.
7,8-Dihydroxyflavone yana faruwa a dabi'a a cikin tushen abinci iri-iri, gami da:
●Ya'yan itãcen marmari: apple, berries, inabi da 'ya'yan itatuwa citrus
● Kayan lambu: albasa, Kale, broccoli da alayyahu
●Ganye: Faski, thyme da oregano
Baya ga waɗannan maɓuɓɓugar halitta, 7,8-DHF kuma ana samun su a cikin kari don dacewa da amfani da aka tsara.
Koyi game da flavonoids
Flavonoids su ne mahaɗan polyphenolic waɗanda ke taka muhimmiyar rawa a cikin launi na shuka, tacewa UV, da juriya na cuta. An raba su zuwa sassa da yawa, ciki har da flavonols, flavones, isoflavones, flavanones, da anthocyanins. Kowane yanki yana da tsarin sinadarai daban-daban da ayyukan nazarin halittu, wanda ke haifar da fa'idodin kiwon lafiya daban-daban.
Menene 7,8-dihydroxyflavone?
7,8-Dihydroxyflavone wani nau'in flavonoid ne na musamman wanda ke cikin rukunin flavonoid. Tsarin sinadaransa yana da ƙungiyoyin hydroxyl guda biyu a matsayi na 7 da 8 na kashin baya na flavonoid, wanda ke da alhakin keɓaɓɓen kaddarorinsa. Ana samun wannan fili da farko a cikin tsire-tsire irin su dioscorea (yam) kuma an yi nazarinsa don yuwuwar tasirin neuroprotective, abubuwan hana kumburi, da haɓaka fahimi.
Mabuɗin Bambanci Tsakanin 7,8-DHF da Sauran Flavonoids
1. Tsarin sinadaran
Babban bambanci tsakanin 7,8-DHF da sauran flavonoids shine tsarin sinadarai. Ko da yake yawancin flavonoids suna raba kashin baya na gama gari, kasancewar ƙungiyoyin hydroxyl a takamaiman matsayi na iya tasiri sosai akan ayyukansu na rayuwa. Alal misali, quercetin, sanannen flavonol, yana da tsari daban-daban na ƙungiyoyin hydroxyl, wanda ke rinjayar solubility da hulɗa tare da maƙasudin nazarin halittu.
2. Ayyukan Halittu
7,8-DHF an nuna yana da ayyukan ilimin halitta na musamman idan aka kwatanta da sauran flavonoids. Bincike ya nuna cewa yana kunna hanyar siginar siginar da aka samu ta hanyar kwakwalwa (BDNF), wanda ke da mahimmanci ga rayuwar neuron, girma da bambanta. Wannan tsarin yana da mahimmanci musamman a cikin mahallin cututtukan neurodegenerative da raguwar fahimi.
Sabanin haka, sauran flavonoids irin su catechins (wanda aka samo a cikin koren shayi) da kuma anthocyanins (wanda aka samo a cikin berries) suna aiki da farko ta hanyar ayyukan antioxidant, kawar da radicals kyauta da rage yawan damuwa. Kodayake waɗannan kaddarorin suna da amfani, ƙila ba za su shafi abubuwan neurotrophic kai tsaye ba kamar yadda 7,8-DHF ke yi.
3. Bioavailability
Bioavailability yana nufin iyaka da ƙimar abin da wani sashi mai aiki ko mai aiki ke sha kuma ya zama samuwa a wurin aiki. 7,8-DHF ya nuna kyakkyawan bioavailability a cikin nazarin dabba, yana nuna cewa zai iya ƙetare shingen kwakwalwar jini da kyau, wanda ke da mahimmanci ga tasirin neuroprotective.
Sabanin haka, bioavailability na sauran flavonoids na iya bambanta sosai. Misali, ko da yake quercetin ana amfani da shi sosai, yawan sha yana iyakancewa saboda saurin metabolism. Wannan bambance-bambance a cikin bioavailability yana rinjayar tasirin waɗannan mahadi don cimma sakamakon lafiya da ake so.
7,8-DHF tsarin aiki: tsarin BDNF da kunna mai karɓa na Trkb
Dangane da tsarin aiki, 7,8-DHF an san shi don haɓaka samar da BDNF (factor neurotrophic da aka samu na kwakwalwa) ta hanyar ɗaurewa da kunna mai karɓa na TrkB. Ba tare da samun fasaha mai yawa ba, wannan yana haifar da raguwa na ayyukan salula wanda ke da amfani wajen kiyaye aikin neuronal da ya dace da kuma inganta neurogenesis.
Babban yanayin aikin 7,8-DHF:
(1) Factor neurotrophic da aka samu Brain (BDNF) da rawar da yake takawa a cikin neuroplasticity
Tare da gano cewa ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa (BDNF) ta ragu a cikin cututtukan neurodegenerative, musamman cutar Alzheimer (AD), mahimmancinsa wajen kiyayewa da haɓaka lafiyar kwakwalwa yana ƙara bayyana.
BDNF yana da mahimmanci ga ayyuka daban-daban na neuronal yayin da yake inganta watsawar synaptic, synaptogenesis, da filastik synaptic ta hanyar sigina tare da masu karɓar TrkB. Wannan ya sa hanyar siginar BDNF-TrkB ta zama manufa mai ban sha'awa don haɓaka hanyoyin maganin warkewa da nufin magance cututtukan neurodegenerative.
(2) Tropomyosin receptor kinase B (Trkb) hanyar siginar mai karɓa
Mai karɓar mai karɓa na tropomyosin kinase B (TrkB) yana taka muhimmiyar rawa wajen daidaita tasirin BDNF akan neurons. A matsayin mai karɓa na tyrosine kinase mai karɓa, TrkB shine mai karɓa na farko don BDNF kuma ya fara ƙaddamar da abubuwan siginar intracellular akan ɗaure ga abubuwan neurotrophic.
BDNF yana kunna TrkB don haifar da hanyoyi masu mahimmanci na ciki, ciki har da phosphatidylinositol 3-kinase (PI3K) -Akt, mitogen-activated protein kinase (MAPK) -extracellular siginar-regulated kinase (ERK), da phospholipase Cγ (PLCγ) -protein kinase C ( PKC) hanyar. Kowane ɗayan waɗannan hanyoyin yana ba da gudummawa ga wani bangare na aikin neuronal da jin daɗin rayuwa.
Hanyar PI3K-Akt tana da mahimmanci don haɓaka rayuwar neuronal da hana apoptosis. BDNF-TrkB siginar yana kunna wannan hanya don ƙara yawan rayuwar sel ta hanyar hana abubuwan pro-apoptotic da ƙarfafa abubuwan anti-apoptotic, don haka tabbatar da kiyaye lafiyar ƙwayoyin cuta.
A gefe guda, hanyar MAPK-ERK tana taka muhimmiyar rawa a cikin bambance-bambancen neuronal da haɓakawa. BDNF-TrkB siginar yana inganta kunna hanyar MAPK-ERK, wanda hakan yana goyan bayan balaga neuronal da bambance-bambancen su da haɗin kai a cikin cibiyoyin sadarwar neuronal.
Hanyar PLCγ-PKC tana da mahimmanci don daidaita filastik synaptic, babban tsari na koyo da ƙwaƙwalwa. BDNF-TrkB siginar yana daidaita ayyukan wannan hanyar, a ƙarshe yana haifar da canje-canje a ƙarfin synaptic da haɗin kai.
Wannan gyare-gyaren yana inganta daidaitawa da sake tsarawa na da'irori na jijiyoyi don mayar da martani ga sababbin abubuwan da suka shafi muhalli.
Ta hanyar yin aiki azaman agonist na TrkB, 7,8-DHF yana aiwatar da tasirinsa na nootropic musamman ta hanyar daidaita hanyoyin siginar da ke da alaƙa da BDNF, ta haka inganta neurogenesis da haɓaka filastik synaptic.
Ta hanyar kwaikwayon tasirin BDNF, 7,8-DHF yana taimakawa kare ƙananan ƙwayoyin cuta daga lalacewa, inganta rayuwar su, da haɓaka haɓakawa da kiyaye sababbin hanyoyin haɗin gwiwa. Wannan ikon haɓaka neuroplasticity, inganta aikin fahimi, da kuma kawar da alamun cututtukan cututtukan jijiyoyin jiki ya sa 7,8-DHF ya zama ɗan takara mai ban sha'awa don haɓakar ƙwayoyi da ƙarin bincike.
7,8-DHF Amfanin Nootropic: Haɓaka Haɓakawa da Kariyar Neuro
Game da fa'idodin nootropic, 7,8-DHF yana aiki ta hanyar manyan hanyoyin 4:
Ƙarfafa ƙwaƙwalwar ajiya da dawo da: aiki mai dogaro da hippocampus
7,8-DHF an samo shi don haɓaka haɓaka ƙwaƙwalwar ajiya da sake dawowa a cikin nau'o'in ilmantarwa na dogara da hippocampus da ayyukan ƙwaƙwalwar ajiya a cikin ƙirar rodent. Wadannan binciken sun nuna cewa 7,8-DHF na iya zama nootropic mai ban sha'awa, Ana iya amfani da shi don inganta aikin ƙwaƙwalwar ajiya a cikin mutane masu lafiya da waɗanda ke da ƙwaƙwalwar ƙwaƙwalwa.
Synaptic plasticity: dogon lokaci mai ƙarfi da damuwa
An nuna 7,8-DHF don daidaita tsarin filastik synaptic ta hanyar inganta LTP da rage LTD a cikin hippocampus. Ana tsammanin waɗannan tasirin za a daidaita su ta ikon kunna masu karɓar TrkB kuma daga baya haɓaka hanyar siginar BDNF. Wannan juzu'i na filastik synaptic yana ba da gudummawa ga haɓakawa a cikin aikin fahimi da aka lura bayan gudanarwar 7,8-DHF.
Abubuwan Antioxidant: ROS scavenging da lipid peroxidation
7,8-DHF yana da kaddarorin antioxidant kamar yadda aka nuna ta ikonsa na lalata nau'in oxygen mai amsawa (ROS) da rage peroxidation na lipid. Wadannan tasirin suna ba da gudummawa ga tasirin neuroprotective ta hanyar kawar da cututtukan oxidative da ke haifar da lalacewar neuronal da rashin aiki.
Tasirin anti-mai kumburi: yana daidaita kunna microglial da samar da cytokine
Baya ga kaddarorin antioxidant, an gano 7,8-DHF don aiwatar da tasirin anti-mai kumburi ta hanyar daidaita aikin kunna microglial da rage samar da cytokines masu kumburi kamar TNF-a da IL-1β. Wannan yana kara ba da gudummawa ga tasirin sa na neuroprotective da nootropic ta hanyar hana kumburi-lalacewar ƙwayoyin cuta.
Lokacin neman mai kaya7,8-DihydroxyflavoneFoda, zaku iya la'akari da waɗannan abubuwan:
1. Sunan mai kaya
Zaɓin mai kaya da kyakkyawan suna yana da mahimmanci. Kuna iya samun ma'anar sunan mai siyarwa ta hanyar duba sake dubawa na abokin ciniki, rahotannin masana'antu, da taron kwararru. Suzhou Myland tana jin daɗin kyakkyawan suna a cikin masana'antar, tare da ingantaccen ra'ayin abokin ciniki da ingancin samfurin da aka sani sosai.
2. ingancin samfur
Tabbatar cewa samfuran da masu samarwa suka samar sun dace da ƙa'idodin ƙasa da ƙasa da buƙatun sarrafa inganci. Suzhou Myland 7,8-Dihydroxyflavone Foda ya yi gwajin ingancin inganci kuma yana da tsabta har zuwa 98%, yana tabbatar da inganci da amincin samfurin.
3. Takaddun shaida da Biyayya
Zaɓin mai ba da kayayyaki tare da GMP (Kyakkyawan Ƙarfafa Ƙarfafawa) da kuma takaddun shaida na ISO yana tabbatar da cewa tsarin samar da shi ya dace da ka'idodin duniya. Suzhou Myland yana bin waɗannan ƙa'idodin don tabbatar da daidaito da daidaiton kowane nau'in samfuran.
4. Tallafin fasaha da sabis
Dole ne mai samar da abin dogaro ya ba da goyan bayan fasaha na ƙwararru da sabis na abokin ciniki. Suzhou Myland yana da ƙwararrun ƙwararrun ƙwararrun ƙwararrun ƙwararru waɗanda za su iya ba abokan ciniki shawarwarin amfani da samfur da jagorar fasaha don taimakawa abokan ciniki samun kyakkyawan sakamako a cikin bincike da aikace-aikacen.
5. Farashin da lokacin bayarwa
Farashi da lokacin bayarwa suma mahimman la'akari ne lokacin zabar mai siyarwa. Kuna iya buƙatar ƙididdiga daga masu samar da kayayyaki da yawa kuma ku kwatanta farashinsu da lokutan bayarwa don nemo zaɓi mafi dacewa. Suzhou Myland
yana ba da farashin gasa da lokutan bayarwa masu sassauƙa yayin tabbatar da ingancin samfur.
Yadda ake samun foda 7,8-Dihydroxyflavone
Idan kuna neman babban ingancin 7,8-Dihydroxyflavone Foda, Suzhou Myland shine kyakkyawan zaɓinku. Kuna iya tuntuɓar mu ta:
Gidan yanar gizon hukuma: Ziyarciofficial website na Suzhou Mylanddon ƙarin koyo game da bayanin samfur da tallafin fasaha.
Tuntuɓar kan layi: Sadarwa kai tsaye tare da ƙungiyar sabis na abokin ciniki ta hanyar aikin tuntuɓar kan layi wanda gidan yanar gizon ya bayar don samun bayanan samfur da ambaton da kuke buƙata.
Lambar waya: Kira lambar lambar mu don sadarwa tare da ƙwararrun ma'aikatan tallace-tallace da samun cikakkun bayanan samfur da shawarwarin siyayya.
Binciken imel: Hakanan zaka iya tambayar mu bayanin samfur ta imel, kuma za mu ba ka amsa da wuri-wuri.
Nemo abin dogara 7,8-Dihydroxyflavone Powder masu samar da foda ba sauki ba, amma ta hanyar kula da sunan mai sayarwa, ingancin samfurin, takaddun shaida da yarda, goyon bayan fasaha da sabis, da farashi da lokacin bayarwa, zaka iya yanke shawara mai hikima. zabi. Suzhou Myland shine abokin tarayya mai kyau tare da babban tsabta 7,8-Dihydroxyflavone foda da kyakkyawan sabis na abokin ciniki. Muna sa ran yin aiki tare da ku don bincika ƙarin damar aikace-aikacen 7,8-Dihydroxyflavone.
Tambaya: Shin proflavin zai iya inganta ikon koyo?
A: Ee, an nuna proflavin don haɓaka yuwuwar koyo a cikin nazarin dabbobi ta hanyar haɓaka hanyoyin neurogenesis da haɗin gwiwar synaptic. Yana daidaita tsarin neurotransmitter waɗanda ke da mahimmanci ga tsarin ilmantarwa, musamman a cikin hippocampus, babban yanki na kwakwalwa don koyo.
Q: Shin 7,8-DHF yana taimakawa dawo da hankali bayan rauni?
A: Ee, binciken bincike na yau da kullun ya nuna cewa 7,8-DHF na iya taimakawa dawo da fahimi bayan rauni na kwakwalwa ta hanyar haɓaka neuroprotection da neuroregeneration. Yana rage mutuwar neuronal kuma yana tallafawa haɓakar sabbin ƙwayoyin cuta, mai yuwuwar haɓaka aikin fahimi da rauni ta rauni ko rauni na ischemic.
Tambaya: Wace rawa 7,8-dihydroxyflavone ke takawa a cikin raguwar fahimi da ke da alaƙa da tsufa?
A: Binciken da ke fitowa ya nuna cewa 7,8-DHF na iya rage jinkirin raguwar hankali da ke hade da tsufa ta hanyar karewa daga damuwa na oxidative da kumburi, abubuwan yau da kullum a cikin cututtuka masu alaka da shekaru.
Ta hanyar haɓaka matakan BDNF da kunnawa mai karɓa na TrkB, yana taimakawa wajen tabbatar da juriya, kodayake ana buƙatar ƙarin nazarin ɗan adam don bincika waɗannan tasirin sosai.
Q: Shin 7,8-DHF na iya inganta hankali da aikin zartarwa?
A: Nazarin dabba na farko sun nuna cewa 7,8-DHF na iya inganta hankali da aikin zartarwa ta hanyar haɓaka ƙa'idodin neurotransmitter da haɗin kai a cikin yankunan kwakwalwa da ke cikin waɗannan matakai.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Oktoba-16-2024
