Tsufa wani tsari ne da kowace halitta ke bi. Mutane ba za su iya hana tsufa ba, amma suna iya ɗaukar wasu matakai don rage tsarin tsufa da kuma faruwar cututtukan da suka shafi shekaru. Ɗaya daga cikin fili ya sami kulawa mai yawa-nicotinamide riboside, wanda kuma aka sani da NR. A matsayin NAD + precursor, nicotinamide riboside ana tsammanin yana da tasirin tsufa mai ban mamaki.
Nicotinamide riboside (NR) wani nau'i ne na bitamin B3, wanda kuma aka sani da nicotinic acid ko nicotinic acid. Abu ne da ke faruwa a dabi'a ana samun shi da ɗanɗano a cikin wasu abinci, kamar madara, yisti, da wasu kayan lambu.
NR shine mafarin nicotinamide adenine dinucleotide (NAD+), coenzyme da ke cikin dukkan sel masu rai. NAD + yana taka muhimmiyar rawa a cikin matakai daban-daban na ilimin halitta, gami da samar da makamashi, gyaran DNA, da daidaita tsarin metabolism na salula. Yayin da muke tsufa, matakan NAD + namu suna raguwa, wanda zai iya rinjayar waɗannan ayyuka masu mahimmanci. An gabatar da kari na NR azaman hanyar haɓaka matakan NAD + da yuwuwar rage saurin tsarin tsufa.
Ɗaya daga cikin manyan fa'idodin ƙarin NR shine ikonsa na haɓaka aikin mitochondrial. Mitochondria su ne gidajen wuta na tantanin halitta, alhakin samar da mafi yawan makamashin tantanin halitta a cikin nau'in adenosine triphosphate (ATP). An nuna NR don haɓaka samar da ATP ta hanyar haɓaka matakan NAD +, don haka inganta ingantaccen samar da makamashi da kuma salon salula. Wannan haɓakar samar da makamashi na iya amfana da kyallen takarda da gabobin daban-daban, gami da kwakwalwa, zuciya, da tsokoki.
●Haɓaka kuzarin salula
Nicotinamide riboside yana taka muhimmiyar rawa wajen samar da makamashi ga gidan wutar lantarki, mitochondria. Wannan fili shine farkon nicotinamide adenine dinucleotide (NAD +), wani muhimmin coenzyme da ke da hannu a yawancin hanyoyin salula, musamman ma kuzarin kuzari. Bincike ya nuna cewa haɓakawa tare da NR na iya ƙara matakan NAD + da haɓaka ingantaccen numfashi na salula da samar da makamashi.
Matakan NAD+ suna raguwa yayin da muke tsufa, yana haifar da raunin aikin mitochondrial da ƙananan matakan makamashi gabaɗaya. Duk da haka, ta hanyar ƙarawa tare da nicotinamide riboside, yana yiwuwa a mayar da wannan raguwa da mayar da matakan makamashi na matasa. Hakanan an samo NR don haɓaka juriya ta jiki da haɓaka wasan motsa jiki, yana mai da shi fili mai ban sha'awa ga 'yan wasa da daidaikun mutane waɗanda ke neman ingantacciyar lafiya.
●Inganta gyaran tantanin halitta da rigakafin tsufa
Wani al'amari mai ban sha'awa na nicotinamide riboside shine yuwuwar sa don haɓaka gyaran DNA da magance lalacewar shekaru. NAD + wani muhimmin sashi ne a cikin tsarin gyaran DNA. Ta hanyar haɓaka NR don haɓaka matakan NAD +, za mu iya haɓaka ikon tantanin halitta don gyara DNA, ta haka mafi inganci don kare tsufa.
Bugu da ƙari, NR ta kasance mai tasiri a cikin daidaita mahimman hanyoyin rayuwa mai tsawo, kamar sirtuins, waɗanda ke taka muhimmiyar rawa wajen kiyaye aikin salula mai lafiya. Wadannan kwayoyin halittu masu dadewa suna taimakawa inganta hanyoyin kariya ta salula daga damuwa da inganta tsawon rai gaba daya. Ta hanyar kunna sirtuins, nicotinamide riboside na iya taimakawa jinkirta cututtukan da suka shafi shekaru kuma yana iya tsawaita tsawon lafiyar mu.
●Hana cututtukan neurodegenerative
Cututtukan neurodegenerative kamar Alzheimer's da Parkinson's suna ƙara zama ruwan dare a cikin al'ummarmu. Bincike ya nuna cewa nicotinamide riboside na iya samun alƙawarin hana waɗannan cututtuka masu rauni. Nazarin ya gano cewa gudanarwa na NR yana haɓaka aikin mitochondrial, yana rage yawan damuwa, kuma yana inganta neuroplasticity, duk abin da ke taimakawa ga kwakwalwa mai koshin lafiya.
Bugu da ƙari, an haɗa ƙarin NR zuwa ingantaccen aikin fahimi, riƙe ƙwaƙwalwar ajiya, da ingantaccen mayar da hankali da tazara. Yayin da ake buƙatar ƙarin bincike, waɗannan binciken na farko sun nuna cewa nicotinamide riboside na iya tabbatar da cewa zai iya zama ma'auni mai kariya ko tallafi ga mutane da ke cikin hadarin neurodegeneration.
●Haɓaka ji na insulin
Yawancin karatu sun nuna cewa NR yana da damar inganta lafiyar lafiyar jiki gaba ɗaya. An nuna shi don haɓaka haɓakar insulin, mahimmin abu don kiyaye matakan sukarin jini lafiya da hana haɓakar nau'in ciwon sukari na 2. Nazarin kuma sun gano cewa kari na NR zai iya inganta metabolism na lipid, ta haka ne rage tasirin cholesterol da matakan triglyceride. Wadannan tasirin suna da mahimmanci musamman a cikin mutanen da ke fama da rashin lafiya ko waɗanda ke da kiba ko kiba.
●Yana da ƙarfin antioxidant
Bugu da ƙari, an nuna NR don haɓaka tsaro na salula daga damuwa na oxidative. Damuwa na Oxidative yana faruwa lokacin da aka sami rashin daidaituwa tsakanin samar da nau'in oxygen mai amsawa (ROS) da ikon jiki don kawar da su da antioxidants. Babban matakan damuwa na oxidative na iya lalata sel kuma yana ba da gudummawa ga ci gaban cututtuka daban-daban, ciki har da ciwon daji, cututtukan zuciya, da cututtukan neurodegenerative. Nazarin ya gano cewa haɓaka NR zai iya inganta ƙarfin antioxidant na sel kuma rage tasirin danniya na oxidative a jiki.
Bincike ya nuna cewa nicotinamide riboside yana da yuwuwar rage tsufa ta hanyar haɓaka matakan nicotinamide adenine dinucleotide (NAD+). NAD + shine maɓalli mai mahimmanci wanda ke taka muhimmiyar rawa a cikin metabolism na salula.
Matakan NAD+ a zahiri suna raguwa yayin da muke tsufa. Ana ɗaukar wannan raguwa a matsayin babban dalilin tsarin tsufa. Ta hanyar haɓaka matakan NAD +, nicotinamide riboside na iya taimakawa rage wannan raguwar da rage tasirin tsufa.
NAD + yana da hannu a yawancin mahimman hanyoyin salula, ciki har da samar da makamashi, gyaran DNA, da bayanin kwayoyin halitta. Ta hanyar haɓaka matakan NAD +, nicotinamide riboside na iya haɓaka waɗannan hanyoyin da haɓaka aikin salon salula gaba ɗaya.
Yawancin bincike sun nuna sakamako mai ban sha'awa a cikin kwayoyin dabbobi da na mutum. A cikin binciken daya, masu bincike sun gano cewa nicotinamide riboside supplementation yana haɓaka matakan NAD + a cikin ƙwayar tsoka, don haka inganta aikin mitochondrial da aikin motsa jiki a cikin mice.
Wani bincike ya gano cewa nicotinamide riboside supplementation inganta insulin hankali da glucose haƙuri a cikin kiba, prediabetic berayen. Wannan yana nuna cewa nicotinamide riboside na iya samun fa'idodi masu amfani ga lafiyar rayuwa.
A cikin ƙaramin ƙarami guda ɗaya na masu matsakaici da tsofaffi, haɓakar nicotinamide riboside ya haɓaka matakan NAD + da haɓaka hawan jini da taurin jijiya, alamomi biyu masu mahimmanci na lafiyar zuciya da jijiyoyin jini.
A cikin wani binciken, masu bincike sun gano cewa nicotinamide riboside supplementation ya inganta aikin tsoka kuma ya hana asarar tsoka a cikin tsofaffi. Wannan yana nuna cewa nicotinamide riboside na iya samun fa'idodi masu fa'ida akan raguwar tsoka da ke da alaƙa da shekaru.
Yana da kyau a lura cewa tsufa tsari ne mai rikitarwa wanda abubuwa da yawa ke tasiri, gami da kwayoyin halitta, salon rayuwa da muhalli. Nicotinamide riboside yakamata a duba shi azaman kari wanda zai iya taimakawa rage tsufa da tallafawa tsufa mai kyau maimakon harsashin sihiri.
Da yawaNAD+ An gano abubuwan da suka gabata, gami da nicotinamide riboside (NR), nicotinamide mononucleotide (NMN), da nicotinic acid (NA). Ana jujjuya waɗannan mafarin zuwa NAD+ sau ɗaya a cikin tantanin halitta.
Daga cikin waɗannan abubuwan da suka gabata, nicotinamide riboside ya sami kulawa sosai saboda kwanciyar hankalin sa, kasancewar sa, da ikon haɓaka matakan NAD + yadda ya kamata. NR shine nau'in bitamin B3 da ke faruwa a zahiri kuma ana samun shi a cikin adadi mai yawa a cikin madara da sauran abinci. An nuna shi don haɓaka haɓakar NAD + da haɓaka ayyukan sirtuins, ƙungiyar sunadaran da ke da alaƙa da tsawon rai.
Ɗaya daga cikin fa'idodin nicotinamide riboside shine ikonsa na ketare matakan tsaka-tsaki da ake buƙata don haɗin NAD+. Ana iya canza shi kai tsaye zuwa NAD + ba tare da buƙatar ƙarin enzymes ba. Sabanin haka, sauran abubuwan da suka faru kamar nicotinamide mononucleotide suna buƙatar ƙarin matakan enzymatic da suka haɗa da nicotinamide phosphoribosyltransferase (NAMPT) zuwa NAD +.
Yawancin karatu sun kwatanta tasirin nicotinamide riboside zuwa sauran abubuwan NAD +, kuma NR koyaushe yana fitowa a saman. A cikin binciken da ya dace a cikin mice masu tsufa, an sami ƙarin haɓakar nicotinamide riboside don haɓaka matakan NAD +, haɓaka aikin mitochondrial, da haɓaka aikin tsoka.
Wani bazuwar, makafi biyu, binciken sarrafa wuribo a cikin manya masu lafiya shima ya nuna sakamako mai ban sha'awa. Matakan NAD + sun karu sosai a cikin mahalarta shan nicotinamide riboside idan aka kwatanta da ƙungiyar placebo. Bugu da ƙari, sun ba da rahoton ingantaccen aikin fahimi da kuma rage gajiya na zahiri.
Yayin da sauran abubuwan da suka faru na NAD +, irin su nicotinamide mononucleotide da niacin, sun nuna tasiri mai kyau akan matakan NAD + a wasu nazarin, har yanzu ba su nuna matakin tasiri kamar nicotinamide riboside ba.
Yana da mahimmanci a lura cewa ko da yake nicotinamide riboside ya bayyana ya fi tasiri a haɓaka matakan NAD +, amsawar mutum na iya bambanta. Wasu mutane na iya gano cewa wasu abubuwan da suka faru, kamar nicotinamide mononucleotide ko niacin, sun fi dacewa da takamaiman bukatunsu.
Ana samun kariyar Nicotinamide riboside a cikin kwamfutar hannu, capsule, da foda. Nemo madaidaicin adadin NR ya dogara da yawa akan abubuwa daban-daban, gami da shekaru, lafiya, da tasirin da ake so. Sabili da haka, yana da kyau koyaushe a tuntuɓi ƙwararrun kiwon lafiya kafin fara kowane sabon tsarin kari, domin suna iya ba da shawara ta keɓance bisa takamaiman bukatunku.
Bugu da kari, tare da shaharar NR da ke tashe-tashen hankula da alamun ƙirƙira suna ambaliya cikin kasuwa, yana da mahimmanci a zaɓi ingantaccen tushe kuma ingantaccen tushe. Ga wasu mahimman abubuwan da za a yi la'akari yayin zabar kari na NR:
1. Tsafta da Inganci: Nemo samfuran da aka gwada na ɓangare na uku kuma an tabbatar da su don tabbatar da sun cika ingantattun ka'idoji. Nemo abubuwan kari waɗanda ba su da abubuwan cikawa, abubuwan ƙari masu cutarwa, da yuwuwar gurɓatawa.
2. Ayyukan Masana'antu: Zaɓi abubuwan da aka ƙera a cikin wuraren da aka yi wa rajista na FDA kuma ku bi ƙa'idodin Ƙarfafa Ƙarfafawa (GMP). Wannan yana tabbatar da daidaiton samfur, aminci da inganci.
4. Suna da kuma Abokin ciniki Reviews: Bincika abokin ciniki reviews da ratings don samun haske a cikin wani kari ta tasiri da kuma overall abokin ciniki gamsuwa.
Tambaya: Ta yaya Nicotinamide Riboside (NR) ke aiki?
A: Nicotinamide Riboside (NR) yana aiki ta hanyar haɓaka matakan NAD + a cikin jiki. NAD + yana shiga cikin samar da makamashin salula, gyaran DNA, da kiyaye lafiya da ayyukan mitochondria.
Tambaya: Menene yuwuwar tasirin rigakafin tsufa na Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) ya nuna alamun rigakafin tsufa ta hanyar rawar da yake takawa wajen haɓaka matakan NAD +. Ƙara yawan matakan NAD + na iya haɓaka aikin mitochondrial, inganta samar da makamashin salula, da inganta gyaran DNA, duk waɗannan zasu iya taimakawa wajen magance raguwar shekaru da inganta lafiyar gaba ɗaya.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Nuwamba-10-2023
