Yayin da muke tsufa, kiyaye lafiyarmu gaba ɗaya yana ƙara zama mahimmanci. Binciken da ke da alaƙa ya nuna cewa nicotinamide riboside, wani nau'i na bitamin B3, na iya yaƙi da tsufa na salula da inganta tsufa. Nicotinamide Riboside Baya ga sabunta ƙwayoyin tsufa, nicotinamide riboside shima yana nuna alƙawarin inganta lafiyar gaba ɗaya da tsawon rai. Nazarin dabba ya nuna cewa kayan abinci na NR na iya tsawaita rayuwa da inganta kiwon lafiya a cikin yanayi daban-daban da suka shafi shekaru, ciki har da kiba, cututtukan zuciya, da cututtukan neurodegenerative.
Tsufa wani tsari ne na dabi'a wanda dukkan halittu masu rai suke sha. A matsayin mutane, jikinmu da tunaninmu suna fuskantar canje-canje da yawa yayin da muke tsufa.
Mafi bayyananne canji shine na fata, tare da wrinkles, shekaru aibobi, da sauransu. Bugu da ƙari, tsokoki sun zama masu rauni, ƙasusuwa sun rasa yawa, haɗin gwiwa sun zama masu ƙarfi, kuma motsi na mutum yana da iyaka.
Wani muhimmin al'amari na tsufa shine ƙara haɗarin cututtuka na yau da kullun kamar cututtukan zuciya, ciwon sukari, da wasu nau'ikan ciwon daji. Bugu da ƙari, raguwar fahimi wata matsala ce ta gama gari. Rashin ƙwaƙwalwar ajiya, wahalar tattarawa, da rage ƙarfin tunani na iya shafar rayuwarmu ta yau da kullun.
Manya da yawa kuma suna samun jin kaɗaici, baƙin ciki, ko damuwa, musamman idan suna fuskantar matsalolin lafiya ko kuma sun rasa waɗanda suke ƙauna. A cikin wannan yanayin, yana da mahimmanci a nemi goyon bayan motsin rai daga dangi, abokai, har ma da kwararru.
Duk da yake ba za mu iya dakatar da tsarin tsufa ba, akwai hanyoyin da za mu iya rage shi kuma mu kiyaye bayyanar ƙuruciya na tsawon lokaci. Kariyar rigakafin tsufa zaɓi ne mai kyau.
NAD + muhimmin coenzyme ne da ake samu a cikin dukkan sel masu rai. Babban aikinsa shi ne haɓaka metabolism na salula ta hanyar taimakawa hanyar canja wurin lantarki a yawancin hanyoyin rayuwa kamar samar da makamashi. Koyaya, yayin da muke tsufa, matakan NAD + a cikin jikinmu suna raguwa ta dabi'a. Wasu nazarin sun nuna cewa raguwar matakan NAD+ na iya zama abin ba da gudummawa ga tsarin tsufa.
Ɗaya daga cikin manyan ci gaba a cikin bincike na NAD + shine gano kwayoyin NAD + precursor da ake kira nicotinamide riboside (NR). NR wani nau'i ne na bitamin B3 wanda ke canzawa zuwa NAD + a cikin ƙwayoyin mu. Nazarin dabba da yawa sun nuna sakamako masu ban sha'awa, suna ba da shawarar cewa ƙarin NR na iya haɓaka matakan NAD + kuma yana iya juyar da raguwar shekaru.
Yawancin cututtukan da suka shafi shekaru, irin su cututtukan neurodegenerative da rashin aiki na rayuwa, suna da alaƙa da aikin mitochondrial maras kyau. Mitochondria su ne gidajen wuta na sel, alhakin samar da makamashi. NAD + yana taka muhimmiyar rawa wajen kiyaye mafi kyawun aikin mitochondrial. Ta hanyar kare lafiyar mitochondrial, NAD + yana da yuwuwar rage haɗarin cututtukan da suka shafi shekaru da tsawaita rayuwa.
Bugu da ƙari, NAD + yana shiga cikin ayyukan sirtuins, dangin sunadaran da ke hade da tsawon rai. Sirtuins suna tsara matakai daban-daban na nazarin halittu, gami da gyaran DNA, martanin damuwa na salula, da kumburi. NAD + yana da mahimmanci ga aikin Sirtuin, yana aiki azaman coenzyme wanda ke kunna ayyukan enzymatic. Ta hanyar haɓaka NAD + da haɓaka aikin Sirtuin, ƙila za mu iya jinkirta tsufa da haɓaka lafiya da tsawon rai.
Yawancin karatu sun nuna cewa ƙarin NAD + yana da tasiri mai kyau a cikin ƙirar dabba. Misali, binciken daya a cikin mice ya nuna cewa kari tare da NR inganta aikin tsoka da juriya. Sauran nazarin sun nuna cewa kari na NR na iya haɓaka aikin rayuwa a cikin tsofaffin beraye, yana mai da shi kama da na ƙananan beraye. Wadannan binciken sun nuna cewa kari na NAD + na iya samun irin wannan tasiri a cikin mutane, kodayake ana buƙatar ƙarin bincike.
Nicotinamide riboside(wanda aka fi sani da niagen) wani nau'i ne na niacin (wanda kuma aka sani da bitamin B3) kuma ana samun shi a cikin ƙananan adadi a cikin madara da sauran abinci. Ana iya canza shi zuwaNAD+ cikin sel. A matsayin mai ƙididdigewa, ana ɗaukar NR cikin sauƙi kuma ana jigilar shi zuwa cikin sel, inda aka canza shi zuwa NAD + ta jerin halayen enzymatic.
Nazarin ƙarin NR a duka nazarin dabba da ɗan adam sun nuna sakamako mai ban sha'awa. A cikin mice, an sami ƙarin NR don haɓaka matakan NAD + a cikin kyallen takarda daban-daban da haɓaka aikin rayuwa da mitochondrial.
NAD + yana shiga cikin matakai daban-daban na salon salula waɗanda ke raguwa tare da shekaru, gami da gyaran DNA, samar da makamashi, da ƙa'idodin bayyanar halittar. Ana hasashen cewa sake cika matakan NAD + tare da NR na iya dawo da aikin salula, ta haka inganta lafiya da tsawaita rayuwa.
Bugu da ƙari, a cikin nazarin kiba da maza masu kiba, ƙarin NR yana haɓaka matakan NAD +, don haka inganta haɓakar insulin da aikin mitochondrial. Waɗannan binciken sun nuna cewa ƙarin NR na iya samun yuwuwar aikace-aikace don magance cututtukan rayuwa kamar nau'in ciwon sukari na 2 da kiba.
1. Abubuwan abinci na halitta na nicotinamide riboside
Wata yuwuwar tushen NR shine samfuran kiwo. Wasu bincike sun nuna cewa kayan kiwo sun ƙunshi adadin NR, musamman madara da aka ƙarfafa tare da NR. Koyaya, abun cikin NR a cikin waɗannan samfuran yana da ɗan ƙaramin ƙarfi kuma samun isassun adadi ta hanyar cin abinci kaɗai na iya zama ƙalubale.
Bugu da ƙari ga tushen abinci, ana samun ƙarin NR a cikin capsule ko foda. Ana samun waɗannan abubuwan kari daga tushen halitta kamar yisti ko fermentation na kwayan cuta. NR da aka samu yisti gabaɗaya ana ɗaukar tushen abin dogaro kuma mai dorewa saboda ana iya samar da shi da yawa ba tare da dogaro da tushen dabba ba. NR da aka samar da kwayoyin cuta wani zaɓi ne, galibi ana samun su daga takamaiman nau'ikan ƙwayoyin cuta waɗanda a zahiri ke samar da NR.
2. Karin nicotinamide riboside
Mafi na kowa kuma abin dogara tushen nicotinamide riboside shine ta hanyar abubuwan abinci. Abubuwan kari na NR suna ba da hanya mai dacewa da inganci don tabbatar da mafi kyawun ci na wannan fili mai mahimmanci. Lokacin zabar mafi kyawun kari na NR, yana da mahimmanci a yi la'akari da waɗannan abubuwan:
a) Tabbacin Inganci: Nemo ƙarin abubuwan da kamfanoni masu daraja suka yi kuma a bi tsauraran matakan sarrafa inganci. Wannan zai tabbatar da samun samfur mai inganci mara ƙazanta ko ƙazanta.
b) Bioavailability: Abubuwan da ake amfani da su na NR suna amfani da tsarin isarwa na ci gaba irin su encapsulation ko fasaha na liposome don haɓaka bioavailability na NR ta yadda jiki zai iya amfani da shi da kyau. Zaɓi irin wannan ƙarin don haɓaka fa'idodin da kuke samu daga NR.
c) Tsafta: Tabbatar cewa ƙarin NR da kuka zaɓa yana da tsafta kuma ba ya ƙunshi abubuwan da ba dole ba, masu cikawa ko abubuwan kiyayewa. Takaddun karantawa da fahimtar abubuwan sinadaran na iya taimaka muku yanke shawara mai ilimi.
1. Haɓaka samar da makamashin salula
NR tana taka muhimmiyar rawa wajen samar da mahimman kwayoyin nicotinamide adenine dinucleotide (NAD+). NAD + yana shiga cikin matakai daban-daban na salon salula, gami da metabolism na makamashi. Yayin da muke tsufa, matakan NAD + a jikinmu suna raguwa, yana haifar da raguwar samar da makamashi. Ta hanyar haɓaka haɓakar NAD +, NR yana taimakawa haɓaka sel da ba da damar samar da makamashi mai inganci. Wannan ingantaccen makamashin salula yana ƙara kuzari, inganta aikin jiki, kuma yana rage gajiya.
2. Anti-tsufa da gyaran DNA
Rage matakan NAD + yana da alaƙa da tsufa da cututtukan da suka shafi shekaru. NR na iya ƙara matakan NAD + a cikin jiki, yana mai da shi wakili mai mahimmanci na rigakafin tsufa. NAD + yana shiga cikin hanyoyin gyaran DNA, yana tabbatar da amincin kayan halittar mu. Ta hanyar haɓaka gyaran DNA, NR na iya taimakawa hana lalacewar DNA da ke da alaƙa da shekaru da tallafawa tsufa mai kyau. Bugu da ƙari, rawar NR a kunna sirtuins, aji na sunadaran da aka sani don daidaita lafiyar salula da tsawon rayuwa, yana ƙara haɓaka yuwuwar rigakafin tsufa.
3. Lafiyar zuciya
Kula da tsarin lafiya na zuciya yana da mahimmanci ga lafiyar gaba ɗaya. Nicotinamide riboside ya nuna sakamako mai ban sha'awa akan lafiyar zuciya. Yana goyan bayan aikin kwayoyin endothelial na jijiyoyin jini, yana inganta yaduwar jini kuma yana rage kumburi. NR kuma yana inganta aikin mitochondrial a cikin ƙwayoyin zuciya, yana hana damuwa na oxidative da inganta samar da makamashi. Wadannan tasirin na iya taimakawa rage haɗarin cututtukan cututtukan zuciya kamar atherosclerosis da gazawar zuciya.
4. Neuroprotection da aikin fahimi
An nuna NR yana da kaddarorin neuroprotective, yana mai da shi mai yuwuwar haɗin gwiwa don kiyaye lafiyar kwakwalwa. Zai iya samun tasiri mai kyau akan aikin neuronal kuma yana kare kariya daga raguwar fahimi mai alaka da shekaru. Ta hanyar haɓaka matakan NAD +, NR yana goyan bayan aikin mitochondrial a cikin ƙwayoyin kwakwalwa, yana haɓaka samar da makamashi da inganta gyaran salula. Inganta aikin mitochondrial na iya haɓaka iyawar fahimta kamar ƙwaƙwalwar ajiya, maida hankali, da tsaftar tunani gabaɗaya.
5. Gudanar da Nauyi da Lafiyar Jiki
Kula da lafiyayyen nauyi da ma'auni na rayuwa yana da mahimmanci ga lafiyar mu gaba ɗaya. An danganta NR zuwa tasirin amfani akan metabolism, yana mai da shi yuwuwar taimako a cikin sarrafa nauyi. NR yana kunna sunadaran da ake kira Sirtuin 1 (SIRT1), wanda ke daidaita matakan rayuwa kamar glucose metabolism da ajiyar mai. Ta hanyar kunna SIRT1, NR na iya taimakawa asarar nauyi da inganta lafiyar rayuwa, ta haka rage haɗarin cututtuka kamar kiba da nau'in ciwon sukari na 2.
Tambaya: Menene Nicotinamide Riboside (NR)?
A: Nicotinamide Riboside (NR) shine mafarin nicotinamide Adenine Dinucleotide (NAD +), coenzyme wanda ke taka muhimmiyar rawa a cikin hanyoyin rayuwa daban-daban, gami da samar da makamashi da daidaita ayyukan rayuwa da salon salula.
Tambaya: Shin Nicotinamide Riboside (NR) zai iya amfana da metabolism?
A: Ee, an gano Nicotinamide Riboside (NR) don amfanar metabolism. Ta hanyar haɓaka matakan NAD +, NR na iya kunna wasu enzymes waɗanda ke cikin metabolism, kamar sirtuins. Wannan kunnawa na iya yuwuwar haɓaka haɓakar haɓakar rayuwa, haɓaka haɓakar insulin, da tallafawa sarrafa nauyi mai kyau.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Nuwamba-13-2023
