Taurine yana da mahimmancin micronutrient da aminosulfonic acid mai yawa. An rarraba shi sosai a cikin kyallen takarda da gabobin jiki daban-daban. Yana wanzuwa a cikin 'yanci a cikin ruwan tsaka-tsaki da ruwan cikin salula. Domin ya fara wanzuwa da Sunan sa bayan an same shi a cikin bishiyar sa. Ana ƙara Taurine zuwa abubuwan sha na yau da kullun na aiki don ƙara kuzari da haɓaka gajiya.
Kwanan nan, an buga bincike kan taurine a cikin manyan mujallu uku na Kimiyya, Cell, da Nature. Wadannan nazarin sun bayyana sababbin ayyuka na taurine - anti-tsufa, inganta tasirin maganin ciwon daji, da kuma kiba.
A cikin Yuni 2023, masu bincike daga Cibiyar Nazarin Immunology ta ƙasa a Indiya, Jami'ar Columbia a Amurka, da sauran cibiyoyi sun buga takardu a cikin babbar mujallar kimiyya ta duniya. Binciken ya nuna cewa rashi taurine shine ke haifar da tsufa. Ƙara taurine na iya rage tsufan nematodes, beraye, da birai, kuma yana iya tsawaita tsawon rayuwar berayen masu matsakaicin shekaru da kashi 12%. Cikakkun bayanai: Kimiyya: Ƙarfi fiye da tunanin ku! Taurine kuma na iya juyar da tsufa da tsawaita rayuwa?
A cikin Afrilu 2024, Farfesa Zhao Xiaodi, Mataimakin Farfesa Lu Yuanyuan, Farfesa Nie Yongzhan, da Farfesa Wang Xin daga Asibitin Xijing na Jami'ar Kiwon Lafiya ta Soja ta Hudu sun buga takarda a cikin babbar mujallar ilimi ta duniya Cell. Wannan binciken ya gano cewa ƙwayoyin tumor suna yin gogayya da ƙwayoyin CD8+ T don taurine ta hanyar wuce gona da iri taurine transporter SLC6A6, wanda ke haifar da mutuwar cell T da gajiya, wanda ke haifar da kubutawar ƙwayar cuta, ta haka yana inganta ci gaban ƙwayar cuta da sake dawowa, yayin da ƙarin Taurine zai iya sake kunna CD8+ T da suka gaji. da inganta tasirin maganin ciwon daji.
A ranar 7 ga Agusta, 2024, ƙungiyar Jonathan Z. Long na Jami'ar Stanford (Dr. Wei Wei shi ne marubuci na farko) ya wallafa wata takarda bincike mai suna: PTER wani N-acetyl taurine hydrolase ne wanda ke tsara ciyarwa da kiba a cikin manyan makarantun duniya. jarida Nature.
Wannan binciken ya gano N-acetyl taurine hydrolase na farko a cikin dabbobi masu shayarwa, PTER, kuma ya tabbatar da muhimmiyar rawar da N-acetyl taurine ke da shi wajen rage cin abinci da kuma hana kiba. A nan gaba, yana yiwuwa a haɓaka masu hana PTER masu ƙarfi da zaɓaɓɓu don maganin kiba.
Ana samun Taurine sosai a cikin kyallen jikin dabbobi masu shayarwa da abinci da yawa kuma ana samunsa a cikin musamman maɗaukakiyar yawa a cikin kyallen takarda masu ban sha'awa kamar zuciya, idanu, kwakwalwa, da tsokoki. An bayyana Taurine don yana da aikin salula na pleiotropic da ayyukan physiological, musamman a cikin mahallin homeostasis na rayuwa. Ragewar kwayoyin halitta a cikin matakan taurine yana haifar da atrophy na tsoka, rage ƙarfin motsa jiki, da rashin aikin mitochondrial a cikin kyallen takarda da yawa. Kariyar taurine yana rage damuwa na mitochondrial redox, inganta ƙarfin motsa jiki, kuma yana hana nauyin jiki.
Kwayoyin ilimin halitta da enzymology na taurine metabolism sun jawo hankalin bincike mai yawa. A cikin endogenous taurine biosynthetic hanya, cysteine ana metabolized ta cysteine dioxygenase (CDO) da cysteine sulfinate decarboxylase (CSAD) don samar da hypotaurine, wanda daga baya Oxidation ta flavin monooxygenase 1 (FMO1) yana samar da taurine. Bugu da ƙari, cysteine zai iya haifar da hypotaurine ta hanyar madadin hanyar cysteamine da cysteamine dioxygenase (ADO). Ƙarƙashin taurine kanta yana da yawa taurine metabolites, ciki har da taurocholate, tauramidine, da N-acetyl taurine. Enzyme kawai da aka sani don haɓaka waɗannan hanyoyin ƙasa shine BAAT, wanda ke haɗa taurine tare da bile acyl-CoA don samar da taurocholate da sauran gishirin bile. Baya ga BAAT, har yanzu ba a tantance asalin ƙwayoyin ƙwayoyin cuta na sauran enzymes masu tsaka-tsakin metabolism na taurine na biyu ba.
N-acetyltaurine (N-acetyl taurine) abu ne mai ban sha'awa musamman amma rashin ingantaccen nazarin metabolite na taurine. Matakan N-acetyl taurine a cikin ruwayen halittu ana daidaita su ta hanyar rikice-rikice na physiological da yawa waɗanda ke ƙara yawan taurine da/ko acetate, gami da motsa jiki na juriya, shan barasa, da ƙarin taurine mai gina jiki. Bugu da ƙari, N-acetyltaurine yana da kamannin tsarin sinadarai zuwa siginar kwayoyin halitta ciki har da neurotransmitter acetylcholine da dogon sarkar N-fatty acyltaurine wanda ke daidaita sukarin jini, yana nuna cewa yana iya aiki azaman siginar sigina samfurin yana aiki. Koyaya, biosynthesis, lalacewa, da yuwuwar ayyuka na N-acetyl taurine ba su da tabbas.
A cikin wannan sabon binciken, ƙungiyar binciken ta gano PTER, wani enzyme marayu wanda ba a san shi ba, a matsayin babban mammalian N-acetyl taurine hydrolase. A cikin vitro, recombinant PTER ya baje kolin kunkuntar kewayo da manyan iyakoki. A cikin N-acetyl taurine, an sanya shi hydrolyzed zuwa taurine da acetate.
Ƙaddamar da kwayar halittar Pter a cikin mice yana haifar da cikakkiyar asarar aikin N-acetyl taurine hydrolytic a cikin kyallen takarda da haɓakar tsari a cikin N-acetyl taurine abun ciki a cikin kyallen takarda daban-daban.
Wurin PTER na ɗan adam yana da alaƙa da ma'auni na jiki (BMI). Ƙungiyar binciken ta ƙara gano cewa bayan ƙarfafawa tare da ƙara yawan matakan taurine, Pter knockout berayen sun nuna raguwar cin abinci kuma suna da tsayayya ga kiba da ke haifar da abinci. da kuma inganta glucose homeostasis. Kariyar N-acetyl taurine zuwa nau'in berayen daji masu kiba shima ya rage cin abinci da nauyin jiki ta hanyar dogaro da GFRAL.
Wadannan bayanan abun ciki a Core enzyme node na taurine secon seconthism kuma bayyana matsayin na per da kuma daidaita makamashi.
Gabaɗaya, wannan binciken ya gano farkon acetyl taurine hydrolase a cikin dabbobi masu shayarwa, PTER, kuma ya tabbatar da muhimmiyar rawar da acetyl taurine ke takawa wajen rage cin abinci da ƙiba. A nan gaba, ana sa ran za a samar da masu hana PTER masu ƙarfi da zaɓaɓɓu don maganin kiba.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Agusta-12-2024
