Urolithin A sune mahadi na halitta waɗanda sune mahaɗan metabolite waɗanda ƙwayoyin cuta na hanji ke samarwa waɗanda ke canza ellagitannins don haɓaka lafiya a matakin salula. Urolithin B ya sami hankalin masu bincike don ikonsa na inganta lafiyar hanji da rage kumburi. Urolithin A da urolithin B suna da kaddarorin da ke da alaƙa, amma suna da bambance-bambance daban-daban. Menene takamaiman bambance-bambancen ku, bari mu gano!
A cikin 'yan shekarun nan, masana kimiyya suna nazarin fa'idodin kiwon lafiya na urolithin, wani sinadari na halitta wanda shine sinadari na metabolite da aka samar ta hanyar canza ellagitannins ta kwayoyin hanji. Abubuwan da ke gaba da shi sune ellagic acid da ellagitannins, waɗanda ke faruwa a zahiri a cikin hanyoyin abinci da yawa kamar rumman, guava, shayi, pecans, goro, da berries kamar strawberries, black raspberries, da blackberries. Bugu da ƙari, urolithin A, polyphenol na halitta, yana da sha'awa a matsayin mai karfi antioxidant da anti-mai kumburi wakili tare da lafiya amfanin lafiya.
Skaratu na bincike the sakamakon UA akan ayyukan salula da hanyoyin nazarin halittu sun nuna cewa yana da hanyoyin aiki da yawa. Har ila yau, binciken ya gano cewa UA tana kunna mitochondrial autophagy, wani tsari da ke kawar da lalata mitochondria daga tantanin halitta kuma yana inganta samar da makamashi. Wannan aikin yana da mahimmanci musamman ga cututtukan da ke da alaƙa da tsufa, kamar yadda mitochondria dysfunctional yana haifar da tarin damuwa na oxidative da kumburi. UA kuma tana daidaita maganganun kwayoyin halittar da ke cikin amsawar damuwa na oxidative, gyaran DNA da apoptosis, waɗanda ke da mahimmanci don kiyaye amincin salon salula da hana ciwon daji.
Wanir ban sha'awa al'amari na UA neyuwuwar sa a matsayin mai ɓacin rai, wanda ke nufin yana iya zaɓin haifar da apoptosis a cikin sel masu hankali, waɗanda sel masu lalacewa waɗanda ba sa rarrabawa amma suna ɓoye abubuwa masu cutarwa waɗanda ke cutar da sel da kyallen maƙwabta. Kwayoyin jijiyoyi suna hade da cututtuka daban-daban masu alaka da tsufa, irin su arthritis, atherosclerosis da neurodegeneration. Ta hanyar zaɓin kawar da waɗannan ƙwayoyin, UA na iya jinkirta ko hana farkon waɗannan cututtuka da inganta lafiyar gaba ɗaya.
Urolithins wani nau'in mahadi ne da aka sani da ellagitannin metabolites, waɗanda akasari ke samarwa ta hanyar microbiota. Daga cikin su, kwayoyin halitta guda biyu, urolithin A da urolithin B, sun sami kulawa sosai don amfanin lafiyar su. Ana samun waɗannan mahadi a cikin 'ya'yan itatuwa daban-daban kamar rumman, strawberries, da raspberries. A cikin wannan shafi, za mu yi nazari sosai kan abubuwan da suka danganci urolithin A da urolithin B.
Urolithin A shine mafi yawan kwayoyin halitta na dangin urolithin, kuma an yi bincike sosai don maganin antioxidant da anti-inflammatory Properties. Bugu da ƙari, nazarin ya nuna cewa UA zai iya inganta aikin mitochondrial kuma ya hana lalacewar tsoka. UA kuma an santa da yuwuwar abubuwan rigakafin cutar kansa. Bincike ya nuna cewa UA na iya hana yaduwar kwayar halitta da kuma haifar da mutuwar kwayar halitta a cikin nau'o'in kwayoyin cutar kansa, ciki har da prostate, nono, da ciwon daji na hanji.
A gefe guda kuma, urolithin B ya sami kulawar masu bincike don ikonsa na inganta lafiyar hanji da rage kumburi. Nazarin ya nuna cewa UB na iya haɓaka bambance-bambancen ƙananan ƙwayoyin cuta da kuma rage cytokines masu kumburi, irin su interleukin-6 da ƙari necrosis factor-alpha. Bugu da ƙari kuma, an gano UB ɗin yana da yuwuwar kaddarorin ƙwayoyin cuta, kamar yadda bincike ya nuna cewa zai iya taimakawa hana cututtukan neurodegenerative kamar Parkinson's da Alzheimer's.
Duk da kaddarorin da ke da alaƙa, UA da UB suna da wasu bambance-bambance masu mahimmanci. Misali, an nuna UA ya fi ƙarfi azaman anti-mai kumburi da wakili na antioxidant fiye da UB. A gefe guda, an gano UB yana da tasiri sosai wajen rigakafin matsalolin da ke da alaƙa da kiba, kamar juriya na insulin da bambancin adipocyte. Bugu da ƙari, ba kamar UA ba, UB ba a yi nazari sosai a matsayin wakili na rigakafin ciwon daji ba.
Tsarin aiki na UA da UB shima ya bambanta. UA tana kunna hanyar Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1a), wanda ke taka rawa a cikin biogenesis na mitochondrial, yayin da UB yana haɓaka hanyar AMP-activated protein kinase (AMPK), wanda ke shiga cikin makamashi homeostasis. Wadannan hanyoyin suna ba da gudummawa ga tasirin amfanin waɗannan mahadi akan lafiya.
Duk da fa'idodi masu ban sha'awa na UA da UB, har yanzu akwai iyakoki ga amfani da su. Misali, kasancewar wadannan mahadi har yanzu ba su da yawa, kuma ba a fahimci magungunansu da kyau ba. Bugu da ƙari, tasirin waɗannan mahadi a kan mutane har yanzu ba a bayyana shi sosai ba, kamar yadda yawancin binciken da aka gudanar a cikin vitro ko a cikin dabbobi. Duk da haka, binciken da ake ciki ya nuna cewa UA da UB na iya zama masu yin alƙawarin ƴan takara don haɓaka abinci mai aiki ko kari don tallafawa lafiyar gabaɗaya da hana cuta.
Urolithin A. Wannan kankanin kwayoyin halittar da aka samu ta dabi'a a cikin wasu 'ya'yan itatuwa da goro ya shahara saboda iyawarsa ta inganta komai daga ci gaban tsoka zuwa aikin kwakwalwa. Urolithin A shine metabolite, wanda ke nufin shi ne ta hanyar sauran mahadi a cikin jiki. Musamman, ana samar da ita lokacin da ƙwayoyin cuta na hanji suka rushe ellagitannins, waɗanda ake samu a wasu abinci kamar rumman, strawberries da walnuts. Amma a nan ne bangare mai ban sha'awa: ba kowa ba ne ke da kwayoyin cutar gut da ake bukata don samar da urolithin A. A gaskiya ma, bincike ya nuna cewa kusan 30-50% na mutane ne kawai za su iya samar da wannan kwayoyin halitta. Wannan shi ne inda kari ya zo da amfani.
Don haka, meneneamfanin urolitin A? To, ɗayan manyan da'awar shine cewa zai iya taimakawa inganta lafiyar tsoka. Wani binciken da aka buga a mujallar Nature Medicine ya gano cewa lokacin da aka bai wa berayen urolithin A, sun sami karuwar juriya da kashi 42% da kuma karuwar 70% na yawan tsoka. Duk da yake waɗannan sakamakon suna da ban sha'awa, yana da kyau a lura cewa wannan ƙaramin bincike ne kuma ana buƙatar ƙarin bincike don tabbatar da waɗannan binciken a cikin ɗan adam.
Amma ba wannan ne kawai abin da ake cewa urolithin A zai yi ba. Hakanan an nuna shi don inganta aikin mitochondrial. Mitochondria su ne ainihin tsire-tsire masu ƙarfi na sel, alhakin samar da makamashi wanda jiki zai iya amfani da shi. Yayin da muke tsufa, aikin mitochondrial ya fara raguwa, wanda zai iya haifar da matsalolin lafiya da yawa. Duk da haka, bincike na farko ya nuna cewa urolitin A na iya taimakawa wajen rage wannan raguwa, mai yiwuwa inganta lafiyar gaba ɗaya da kuma tsawaita tsawon rayuwa.
Kamar dai hakan bai isa ba, an kuma nuna urolithin A yana da fa'idodin fahimi. Wani bincike da aka buga a mujallar Scientific Reports ya gano cewa lokacin da aka ba berayen urolithin A, ƙwaƙwalwarsu da ƙwarewar karatunsu sun inganta. Masu bincike sun yi imanin cewa hakan na iya kasancewa saboda tasirin ƙwayoyin cuta, wanda ke taimakawa kare ƙwayoyin kwakwalwa daga lalacewa.
Urolithin B, wani fili da ake samu a cikin berries daban-daban da rumman, an san shi da yuwuwar amfanin sa wajen inganta lafiyar rayuwa da tsawaita rayuwa. Binciken da aka yi kwanan nan ya nuna cewa urolithin B yana da kayan anti-inflammatory da antioxidant Properties wanda zai iya taimakawa wajen hana cututtuka na yau da kullum da kuma inganta lafiyar gaba ɗaya.
1. Anti-mai kumburi Properties
Kumburi na yau da kullun shine babban abin da ke haifar da cututtuka da yawa, ciki har da cututtukan zuciya, ciwon sukari da ciwon daji. Urolithin B yana da kaddarorin anti-mai kumburi wanda ke taimakawa rage kumburi a cikin jiki, don haka rage haɗarin kamuwa da cuta na yau da kullun. Ɗaya daga cikin binciken ya gano cewa urolithin B ya rage yawan kumburi a cikin berayen tare da cututtukan hanji mai kumburi, yana nuna yiwuwar tasirinsa wajen magance mutane masu irin wannan cututtuka.
2. Antioxidant Properties
Urolithin B shine antioxidant mai karfi, wanda ke nufin zai iya taimakawa wajen kare jiki daga damuwa na oxidative, tsarin da ke lalata kwayoyin halitta kuma yana inganta tsarin tsufa. Urolithin B yana taimakawa hana lalacewar oxidative ta hanyar kawar da radicals kyauta, wanda zai iya haifar da lalacewar salula kuma ya haifar da cututtuka na yau da kullum. Ɗaya daga cikin binciken ya gano cewa urolithin B yana rage yawan damuwa a cikin rodents, yana kara tallafawa yiwuwarsa a matsayin ƙarin maganin tsufa.
3. Inganta lafiyar tsoka
An nuna Urolithin B don tayar da mitochondrial autophagy, tsarin salula wanda ke taimakawa wajen kawar da mitochondria mai lalacewa daga sel. Wannan tsari yana taimakawa wajen inganta lafiyar tsoka da aiki gabaɗaya, yana mai da shi ƙarin ƙari ga waɗanda ke neman haɓaka aikin jiki. Ɗaya daga cikin binciken ya gano cewa urolithin B yana inganta aikin tsoka da ƙarfi a cikin mice da mutane.
4. Yana goyan bayan lafiyar hankali
An nuna Urolithin B don tallafawa lafiyar hankali ta hanyar inganta neuroplasticity, tsarin da ke taimakawa kwakwalwa ta dace da sabon bayani kuma zai iya inganta aikin tunani. Ɗaya daga cikin binciken ya gano cewa urolithin B ya inganta aikin tunani da haɓaka ƙwaƙwalwar ajiya a cikin berayen.
5. Yiwuwar fa'idar tsawon rai
Binciken da aka yi kwanan nan ya nuna cewa urolithin B yana da damar inganta tsawon rai ta hanyar inganta lafiyar jiki, rage kumburi, da kuma kare kariya daga damuwa na oxidative. Ɗaya daga cikin binciken ya gano cewa urolithin B yana ƙara yawan rayuwa a cikin C. elegans, nau'in tsutsotsi na nematode, yana goyan bayan fa'idodin amfaninsa don haɓaka tsawon rai.
1. Ruman
Ruman yana daya daga cikin mafi kyawun tushen urolithin. Masu bincike sun gano cewa ruwan 'ya'yan rumman na iya kara yawan matakan jini na urolithins A da B. Bugu da ƙari, rumman yana da wasu fa'idodin kiwon lafiya, ciki har da kayan aikin anti-inflammatory da antioxidant Properties.
2. Berries
Berries irin su strawberries, raspberries da blackberries suma suna da kyau tushen urolithin. Nazarin ya nuna cewa amfani da berry na iya ƙara yawan matakan jini na urolitin A da B.
3. Kwayoyi
Gyada da pecans da sauran goro suma sune tushen urolithin. Wani bincike ya gano cewa shan goro zai kara yawan urolitin A da B a cikin jini.
Urolithin A da B sune mahadi na halitta da ke cikin wasu abinci, suna da fa'idodin kiwon lafiya da yawa. Wadannan mahadi suna da kaddarorin anti-mai kumburi, inganta lafiyar mitochondrial da tsoka, da inganta lafiyar hankali. Ruman, berries, kwayoyi da abubuwan ellagitannin wasu daga cikin mafi kyawun tushen abinci waɗanda zasu iya samar da urolitins. Ciki har da waɗannan abinci a cikin abincinku na iya taimaka muku buɗe fa'idodin urolithines A da B da haɓaka tsufa.
Lokacin aikawa: Juni-05-2023
