Urolithin A mahaɗan halitta ne waɗanda ƙwayoyin cuta na hanji ke samarwa waɗanda ke canza ellagitannins don inganta lafiya a matakin ƙwayoyin halitta. Urolithin B ya jawo hankalin masu bincike saboda iyawarsa ta inganta lafiyar hanji da rage kumburi. Urolithin A da urolithin B suna da halaye masu alaƙa, amma suna da wasu bambance-bambance daban-daban. Menene takamaiman bambance-bambancen ku, bari mu gano!
A cikin 'yan shekarun nan, masana kimiyya suna nazarin fa'idodin urolithin ga lafiya, wani sinadari na halitta wanda wani sinadari ne da kwayoyin halitta ke samarwa ta hanyar canza ellagitannins ta hanyar ƙwayoyin cuta na hanji. Abubuwan da suka fara haifar da shi sune ellagic acid da ellagitannins, waɗanda ke faruwa ta halitta a cikin tushen abinci da yawa kamar rumman, guava, shayi, pecans, goro, da 'ya'yan itace kamar strawberries, black raspberries, da blackberries. Bugu da ƙari, urolithin A, wani sinadari na halitta polyphenol, yana da ban sha'awa a matsayin mai ƙarfi na antioxidant da anti-inflammatory tare da fa'idodi masu kyau na lafiya.
Sbinciken da aka yi a asibitiTasirin UA akan ayyukan ƙwayoyin halitta da hanyoyin halittu sun nuna cewa yana da hanyoyi da yawa na aiki. Bincike ya kuma gano cewa UA yana kunna autophagy na mitochondrial, wani tsari wanda ke cire mitochondria da ya lalace daga ƙwayar halitta kuma yana haɓaka samar da makamashi. Wannan aikin yana da mahimmanci musamman ga cututtukan da ke da alaƙa da tsufa, saboda mitochondria mara aiki yana haifar da tarin damuwa da kumburi. UA kuma yana daidaita bayyanar kwayoyin halitta da ke da hannu a cikin amsawar damuwa ta oxidative, gyaran DNA da apoptosis, waɗanda suke da mahimmanci don kiyaye amincin ƙwayoyin halitta da hana cutar kansa.
WaniBangaren ban sha'awa na UA shineyana da ikon yin amfani da shi azaman mai tattara tsufa, wanda ke nufin cewa yana iya haifar da apoptosis a cikin ƙwayoyin tsufa, waɗanda ƙwayoyin halitta ne da suka lalace waɗanda ba sa rabuwa amma suna ɓoye abubuwa masu cutarwa waɗanda ke cutar da ƙwayoyin da ke maƙwabtaka da kyallen. Kwayoyin tsufa suna da alaƙa da cututtuka daban-daban da suka shafi tsufa, kamar amosanin gabbai, atherosclerosis da neTsarin urodegeneration. Ta hanyar cire waɗannan ƙwayoyin halitta da zaɓi, UA na iya jinkirta ko hana kamuwa da waɗannan cututtuka da kuma inganta lafiyar gaba ɗaya.
Urolithins wani nau'in sinadarai ne da aka sani da ellagitannin metabolites, waɗanda galibi ƙwayoyin cuta na hanji ke samarwa. Daga cikinsu, ƙwayoyin halitta guda biyu, urolithin A da urolithin B, sun sami kulawa sosai game da fa'idodin lafiyarsu. Ana samun waɗannan sinadarai a cikin 'ya'yan itatuwa daban-daban kamar rumman, strawberries, da raspberries. A cikin wannan shafin yanar gizo, za mu yi nazari sosai kan halayen urolithin A da urolithin B.
Urolithin A shine kwayar halittar da ta fi yawa a cikin dangin urolithin, kuma an yi bincike sosai a kanta saboda kaddarorin antioxidant da anti-inflammatory. Bugu da ƙari, bincike ya nuna cewa UA na iya inganta aikin mitochondrial da kuma hana lalacewar tsoka. An kuma san UA saboda yuwuwar kaddarorin anti-cancer. Bincike ya nuna cewa UA na iya hana yaduwar ƙwayoyin halitta da kuma haifar da mutuwar ƙwayoyin halitta a cikin layukan ƙwayoyin cutar kansa daban-daban, gami da ƙwayoyin cutar kansa ta prostate, nono, da hanji.
A gefe guda kuma, urolithin B ya jawo hankalin masu bincike saboda iyawarsa ta inganta lafiyar hanji da kuma rage kumburi. Bincike ya nuna cewa UB na iya haɓaka bambancin ƙwayoyin cuta na hanji da kuma rage cytokines masu hana kumburi, kamar interleukin-6 da tumor necrosis factor-alpha. Bugu da ƙari, an gano cewa UB yana da yuwuwar kariya daga jijiyoyi, kamar yadda bincike ya nuna cewa yana iya taimakawa wajen hana cututtukan jijiyoyi kamar Parkinson da Alzheimer's.
Duk da halayensu masu alaƙa, UA da UB suna da wasu bambance-bambance masu mahimmanci. Misali, an nuna cewa UA ta fi UB ƙarfi a matsayin maganin kumburi da hana tsufa. A gefe guda kuma, an gano cewa UB ta fi tasiri wajen hana rikice-rikicen da suka shafi kiba, kamar juriyar insulin da bambancin adipocyte. Bugu da ƙari, ba kamar UA ba, ba a yi nazari sosai kan UB a matsayin maganin hana ciwon daji ba.
Tsarin aiki na UA da UB shi ma ya bambanta. UA yana kunna hanyar Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α), wadda ke taka rawa a cikin biogenesis na mitochondrial, yayin da UB ke haɓaka hanyar AMP-activated protein kinase (AMPK), wadda ke da hannu a cikin homeostasis na makamashi. Waɗannan hanyoyin suna ba da gudummawa ga tasirin waɗannan mahadi ga lafiya.
Duk da fa'idodin UA da UB masu ban sha'awa, har yanzu akwai ƙuntatawa ga amfani da su. Misali, wadatar waɗannan mahadi har yanzu ba ta da yawa, kuma ba a fahimci tasirin su sosai ba. Bugu da ƙari, tasirin waɗannan mahadi ga mutane har yanzu ba a fayyace shi sosai ba, kamar yadda aka gudanar da yawancin bincike a cikin vitro ko a cikin samfuran dabbobi. Duk da haka, binciken da ake da shi ya nuna cewa UA da UB na iya zama 'yan takara masu alƙawarin haɓaka abinci mai aiki ko kari don tallafawa lafiya gaba ɗaya da hana cututtuka.
Urolithin A. Wannan ƙaramin ƙwayar halitta da ake samu a wasu 'ya'yan itatuwa da goro yana da shahara saboda iyawarsa ta inganta komai tun daga girman tsoka zuwa aikin kwakwalwa. Urolithin A wani sinadari ne, wanda ke nufin yana fitowa ne daga wasu mahadi a jiki. Musamman ma, ana samar da shi ne lokacin da ƙwayoyin cuta na hanji ke lalata ellagitannins, waɗanda ake samu a wasu abinci kamar rumman, strawberries da goro. Amma ga ɓangaren mai ban sha'awa: ba kowa ne ke da ƙwayoyin cuta na hanji da ake buƙata don samar da urolithin A ba. A gaskiya ma, bincike ya nuna cewa kusan kashi 30-50% na mutane ne kawai za su iya samar da wannan ƙwayar halitta ta halitta. Nan ne ƙarin abinci ke da amfani.
To, meneneAmfanin urolithin A? To, ɗaya daga cikin manyan ikirari shine yana iya taimakawa wajen inganta lafiyar tsoka. Wani bincike da aka buga a mujallar Nature Medicine ya gano cewa lokacin da aka ba berayen urolithin A, sun sami ƙaruwar juriya da kashi 42% da kuma ƙaruwar ƙarfin tsoka da kashi 70%. Duk da cewa waɗannan sakamakon tabbas suna da ban sha'awa, ya kamata a lura cewa wannan ƙaramin bincike ne kuma ana buƙatar ƙarin bincike don tabbatar da waɗannan binciken a cikin mutane.
Amma ba haka kawai ake cewa urolithin A yana yi ba. An kuma nuna cewa yana inganta aikin mitochondrial. Mitochondria ainihin su ne tushen makamashin ƙwayoyin halitta, waɗanda ke da alhakin samar da makamashin da jiki zai iya amfani da shi. Yayin da muke tsufa, aikin mitochondrial ɗinmu yana fara raguwa, wanda zai iya haifar da matsaloli da yawa na lafiya. Duk da haka, bincike na farko ya nuna cewa urolithin A na iya taimakawa wajen rage wannan raguwar, wanda zai iya inganta lafiyar gaba ɗaya da kuma tsawaita tsawon rai.
Kamar dai hakan bai isa ba, an kuma nuna cewa urolithin A yana da fa'idodin fahimta. Wani bincike da aka buga a mujallar Scientific Reports ya gano cewa lokacin da aka ba berayen urolithin A, ƙwaƙwalwarsu da ƙwarewar koyo sun inganta. Masu bincike sun yi imanin cewa wannan na iya faruwa ne saboda tasirin ƙwayoyin cuta na hana kumburi, wanda ke taimakawa wajen kare ƙwayoyin kwakwalwa daga lalacewa.
Urolithin B, wani sinadari da ake samu a cikin 'ya'yan itatuwa da rumman daban-daban, an san shi da fa'idodin da ke tattare da shi wajen inganta lafiyar metabolism da tsawaita tsawon rai. Binciken da aka yi kwanan nan ya nuna cewa urolithin B yana da kaddarorin hana kumburi da kuma hana tsufa wanda zai iya taimakawa wajen hana cututtuka masu tsanani da kuma inganta lafiyar gaba daya.
1. Halayen hana kumburi
Kumburi mai ɗorewa babban sanadin cututtuka da dama ne, ciki har da cututtukan zuciya, ciwon suga da kuma ciwon daji. Urolithin B yana da kaddarorin hana kumburi wanda ke taimakawa wajen rage kumburi a jiki, ta haka ne rage haɗarin kamuwa da cututtuka masu ɗorewa. Wani bincike ya gano cewa urolithin B yana rage kumburi a cikin beraye masu fama da cututtukan hanji, wanda ke nuna yuwuwar tasirinsa wajen magance mutane masu irin waɗannan cututtuka.
2. Kayayyakin hana tsufa
Urolithin B wani sinadari ne mai ƙarfi na antioxidant, wanda ke nufin zai iya taimakawa wajen kare jiki daga damuwa ta oxidative, wani tsari da ke lalata ƙwayoyin halitta kuma yana haɓaka tsarin tsufa. Urolithin B yana taimakawa wajen hana lalacewar oxidative ta hanyar kawar da free radicals, wanda zai iya haifar da lalacewar ƙwayoyin halitta da kuma haifar da cututtuka na yau da kullun. Wani bincike ya gano cewa urolithin B yana rage damuwa ta oxidative a cikin beraye, yana ƙara tallafawa yuwuwar sa a matsayin ƙarin maganin hana tsufa.
3. Inganta lafiyar tsoka
An nuna cewa Urolithin B yana ƙarfafa mitochondrial autophagy, wani tsari na ƙwayoyin halitta wanda ke taimakawa wajen kawar da mitochondria da ya lalace daga ƙwayoyin halitta. Wannan tsari yana taimakawa wajen inganta lafiyar tsoka da aikinta gaba ɗaya, wanda hakan ke sa ta zama ƙarin kari ga waɗanda ke neman inganta aikin jiki. Wani bincike ya gano cewa urolithin B yana inganta aikin tsoka da ƙarfi a cikin beraye da mutane.
4. Yana tallafawa lafiyar fahimta
An nuna cewa Urolithin B yana taimakawa lafiyar fahimta ta hanyar haɓaka neuroplasticity, wani tsari wanda ke taimaka wa kwakwalwa ta saba da sabbin bayanai kuma yana iya inganta aikin fahimta. Wani bincike ya gano cewa urolithin B yana inganta aikin fahimta da kuma ƙara ƙwaƙwalwar ajiya a cikin beraye.
5. Fa'idodin da za a iya samu na tsawon rai
Binciken da aka yi kwanan nan ya nuna cewa urolithin B yana da damar haɓaka tsawon rai ta hanyar inganta lafiyar metabolism, rage kumburi, da kuma kariya daga damuwa ta oxidative. Wani bincike ya gano cewa urolithin B yana ƙara tsawon rai a cikin C. elegans, wani nau'in tsutsotsi na nematode, yana tallafawa fa'idodin da ke tattare da haɓaka tsawon rai.
1. Rumman
Rumman yana ɗaya daga cikin mafi kyawun tushen urolithin. Masu bincike sun gano cewa ruwan rumman na iya ƙara yawan urolithins A da B a cikin jini. Bugu da ƙari, rumman yana da wasu fa'idodi na lafiya, gami da hana kumburi da kaddarorin antioxidant.
2. 'Ya'yan itacen Berries
'Ya'yan itacen berries kamar su strawberries, raspberries da blackberries suma suna da kyau wajen samun urolithin. Bincike ya nuna cewa shan 'ya'yan itacen berries na iya ƙara yawan urolithin A da B a jini.
3. Gyada
Gyada da pecan da sauran goro suma suna da kyau wajen samar da urolithin. Wani bincike ya gano cewa shan goro zai kara yawan urolithin A da B a cikin jini.
Urolithin A da B mahaɗan halitta ne da ke cikin wasu abinci, suna da fa'idodi da yawa na kiwon lafiya. Waɗannan mahaɗan suna da kaddarorin hana kumburi, suna inganta lafiyar mitochondrial da tsoka, kuma suna haɓaka lafiyar fahimta. Rumman, 'ya'yan itace, goro da ƙarin ellagitannin suna daga cikin mafi kyawun hanyoyin abinci waɗanda zasu iya samar da urolithins. Haɗa waɗannan abincin a cikin abincinku na iya taimaka muku buɗe fa'idodin urolithins A da B da kuma haɓaka tsufa mai lafiya.
Lokacin Saƙo: Yuni-05-2023
