Urolithin A wani muhimmin abu ne na bioactive wanda aka fi amfani dashi a cikin magani da kuma kula da lafiya. Yana da wani enzyme da koda ke samar da shi kuma yana da aikin narkar da gudan jini. Tasirin sihiri da ayyuka na Urolithin A sun fi bayyana a cikin abubuwa masu zuwa.
Urolitin A yana hana lalacewar tsoka
1. Haɓaka haɗin furotin na tsoka da kunna hanyar siginar mTOR
Manufar mammalian na rapamycin (mTOR) hanyar siginar sigina ita ce hanya mai mahimmanci don daidaita haɗin furotin tsoka. Urolithin A na iya kunna hanyar siginar mTOR kuma yana haɓaka haɗin furotin a cikin ƙwayoyin tsoka.
mTOR na iya fahimtar sigina irin su abubuwan gina jiki da abubuwan girma a cikin sel. Lokacin da aka kunna shi, zai fara jerin kwayoyin siginar da ke ƙasa, irin su furotin na ribosomal S6 kinase (S6K1) da eukaryotic initiation factor 4E-binding protein 1 (4E-BP1). Urolithin A yana kunna mTOR, phosphorylating S6K1 da 4E-BP1, ta haka yana haɓaka fassarar mRNA da taron ribosome, da haɓaka haɗin furotin.
Alal misali, a cikin gwaje-gwaje tare da ƙwayoyin tsoka na al'ada na in vitro, bayan ƙara urolithin A, an lura cewa matakan phosphorylation na mTOR da kwayoyin siginar siginar sa sun karu, kuma alamar alamar sunadaran tsoka (irin su myosin nauyi sarkar) ya karu.
Yana daidaita magana ta musamman na tsoka
Urolitin A zai iya daidaita maganganun tsoka-takamaiman abubuwan rubutu na tsoka waɗanda ke da mahimmanci don haɗin furotin na tsoka da bambancin ƙwayoyin tsoka. Alal misali, yana iya daidaita yanayin yanayin bambancin myogenic (MyoD) da myogenin.
MyoD da Myogenin na iya haɓaka bambance-bambancen ƙwayoyin ƙwayoyin tsoka a cikin ƙwayoyin tsoka da kunna maganganun takamaiman ƙwayoyin tsoka, ta haka inganta haɗin furotin tsoka. A cikin samfurin atrophy na tsoka, bayan jiyya na urolithin A, maganganun MyoD da Myogenin sun karu, wanda ke taimakawa wajen kula da ƙwayar tsoka da kuma hana ƙwayar tsoka.
2. Hana lalacewar furotin na tsoka da kuma hana tsarin ubiquitin-proteasome (UPS)
UPS yana ɗaya daga cikin manyan hanyoyi don lalata furotin tsoka. A lokacin atrophy na tsoka, wasu E3 ubiquitin ligases, irin su tsoka atrophy F-box protein (MAFbx) da tsoka RING furotin yatsa 1 (MuRF1), an kunna, wanda zai iya sanya sunadaran tsoka tare da ubiquitin sa'an nan kuma rage su ta hanyar proteasome.
Urolithin A na iya hana magana da ayyukan waɗannan E3 ubiquitin ligases. A cikin gwaje-gwajen samfurin dabba, urolithin A na iya rage matakan MAFbx da MuRF1, rage alamar haɓakar sunadaran ƙwayoyin tsoka, ta haka ya hana UPS-tsakanin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta.
Modulation na tsarin autophagy-lysosomal (ALS)
ALS tana taka rawa wajen sabunta sunadaran tsoka da gabobin jiki, amma yawan aiki yana iya haifar da atrophy na tsoka. Urolithin A na iya daidaita ALS zuwa matakin da ya dace. Yana iya hana wuce kima autophagy da hana wuce kima lalatar tsoka sunadaran.
Alal misali, urolithin A zai iya daidaita maganganun sunadarai masu alaka da autophagy (irin su LC3-II), ta yadda zai iya kula da homeostasis na yanayin ƙwayar tsoka yayin da yake guje wa wuce gona da iri na sunadaran tsoka, don haka yana taimakawa wajen kula da ƙwayar tsoka.
3. Inganta makamashi metabolism na tsoka Kwayoyin
Ƙunƙarar tsoka na buƙatar makamashi mai yawa, kuma mitochondria shine babban wurin samar da makamashi. Urolithin A na iya haɓaka aikin mitochondria na ƙwayar tsoka da inganta haɓakar samar da makamashi. Yana iya inganta mitochondrial biogenesis kuma yana ƙara yawan mitochondria.
Misali, urolithin A na iya kunna mai karɓar mai karɓar mai haɓaka mai haɓakawa mai haɓakawa γ coactivator-1a (PGC-1α), wanda shine maɓalli mai mahimmanci na biogenesis na mitochondrial, haɓaka kwafin DNA na mitochondrial da haɗin furotin mai alaƙa. A lokaci guda kuma, urolithin A zai iya inganta aikin sarkar numfashi na mitochondrial, ƙara haɓakar adenosine triphosphate (ATP), samar da isasshen makamashi don raguwar tsoka, da rage raguwar tsoka da ke haifar da rashin isasshen makamashi.
Yana daidaita sukari da metabolism na lipid kuma yana tallafawa aikin tsoka
Urolitin A na iya daidaita glucose da lipid metabolism na ƙwayoyin tsoka. Dangane da metabolism na glucose, yana iya haɓaka haɓakawa da amfani da glucose ta ƙwayoyin tsoka, da tabbatar da cewa ƙwayoyin tsoka suna da isassun abubuwan makamashi ta hanyar kunna hanyar siginar insulin ko wasu hanyoyin sigina masu alaƙa da jigilar glucose.
Dangane da metabolism na lipid, urolithin A na iya inganta iskar oxygen mai kitse, samar da wani tushen kuzari don ƙanƙantar tsoka. Ta hanyar inganta glucose da metabolism na lipid, urolithin A yana kula da samar da makamashi na ƙwayoyin tsoka kuma yana taimakawa hana raguwar tsoka.
Urolitin A yana inganta metabolism
1. Daidaita metabolism na sukari da inganta haɓakar insulin
Urolithin A na iya haɓaka haɓakar insulin, wanda ke da mahimmanci don kiyaye kwanciyar hankali na sukari na jini. Yana iya yin aiki akan mahimman ƙwayoyin cuta a cikin hanyar siginar insulin, kamar sunadaran masu karɓar insulin (IRS).
A cikin yanayin juriya na insulin, an hana tyrosine phosphorylation na furotin IRS, wanda ya haifar da gazawar hanyar siginar phosphatidylinositol 3-kinase (PI3K) na ƙasa don kunna ta kullum, kuma amsawar tantanin halitta ga insulin ya raunana.
Urolithin A na iya haɓaka tyrosine phosphorylation na furotin IRS, ta haka yana kunna hanyar siginar PI3K-protein kinase B (Akt), yana ba sel damar samun mafi kyawu da amfani da glucose. Misali, a cikin gwaje-gwajen samfurin dabba, bayan gudanar da urolithin A, an inganta halayen tsoka da adipose ga insulin sosai, kuma an sarrafa matakan sukari na jini yadda ya kamata.
Yana daidaita haɓakar glycogen da lalata
Glycogen shine babban nau'in ajiyar glucose a cikin jiki, galibi ana adana shi a cikin hanta da tsokar tsoka. Urolithin A na iya daidaita kira da bazuwar glycogen. Yana iya kunna glycogen synthase, inganta kira na glycogen, kuma yana ƙara ajiyar glycogen.
A lokaci guda kuma, urolithin A na iya hana ayyukan glycogenolytic enzymes, kamar glycogen phosphorylase, da rage adadin glycogen da ke bazuwa cikin glucose kuma a sake shi cikin jini. Wannan yana taimakawa daidaita matakan sukari na jini da kuma hana yawan hawan jini a cikin sukarin jini. A cikin binciken samfurin ciwon sukari, bayan jiyya na urolithin A, abun ciki na glycogen a cikin hanta da tsokoki ya karu, kuma an inganta sarrafa sukarin jini.
2. inganta lipid metabolism da hana fatty acid kira
Urolitin A yana da tasirin hanawa akan tsarin haɗin lipid. A cikin hanta da adipose nama, yana iya hana maɓalli masu mahimmanci a cikin haɗin acid fatty acid, irin su fatty acid synthase (FAS) da acetyl-CoA carboxylase (ACC).
FAS da ACC sune mahimman enzymes na tsari a cikin haɗin de novo na fatty acids. Urolithin A na iya rage kirar fatty acid ta hanyar hana ayyukansu. Misali, a cikin samfurin hanta mai kitse wanda abinci mai kitse ya jawo, urolithin A zai iya rage ayyukan FAS da ACC a cikin hanta, rage haɗakar triglycerides, don haka yana rage tarin lipid a cikin hanta.
Yana inganta fatty acid oxidation
Baya ga infibited kitse mai kitse, orgithizin a wani kuma na iya inganta lalata da oxideative na kitse. Yana iya kunna hanyoyin sigina da enzymes masu alaƙa da fatty acid oxidation. Misali, yana iya daidaita ayyukan carnitine palmitoyltransferase-1 (CPT-1).
CPT-1 shine maɓalli mai mahimmanci a cikin fatty acid β-oxidation, wanda ke da alhakin jigilar fatty acid zuwa mitochondria don bazuwar oxidative. Urolithin A yana haɓaka β-oxidation na fatty acids ta hanyar kunna CPT-1, yana ƙara yawan kuzarin mai, yana taimakawa rage ajiyar kitsen jiki, kuma yana haɓaka metabolism na lipid.
3. Inganta makamashi metabolism da haɓaka aikin mitochondrial
Mitochondria sune "masana'antar makamashi" na sel, kuma urolithin A na iya haɓaka aikin mitochondria. Yana iya daidaita mitochondrial biogenesis da inganta mitochondrial kira da sabuntawa. Misali, yana iya kunna mai karɓar mai karɓa gamma coactivator-1a (PGC-1α).
PGC-1a shine mabuɗin mai sarrafa mitochondrial biogenesis, wanda zai iya haɓaka kwafin DNA na mitochondrial da haɗin sunadarai masu alaƙa da mitochondrial. Urolithin A yana ƙara lamba da ingancin mitochondria kuma yana haɓaka haɓakar samar da makamashi na sel ta kunna PGC-1a. A lokaci guda kuma, urolithin A na iya inganta aikin sarkar numfashi na mitochondria kuma yana ƙara haɓakar adenosine triphosphate (ATP).
4. Gudanar da Sake Shirye-shiryen Metabolic Cellular
Urolithin A na iya jagorantar sel don aiwatar da tsarin sake fasalin rayuwa, yana sa metabolism na tantanin halitta ya fi dacewa. Ƙarƙashin wasu yanayi na damuwa ko cututtuka, tsarin rayuwa na tantanin halitta na iya canzawa, wanda zai haifar da raguwar tasiri a samar da makamashi da haɗin abubuwa.
Urolithin A na iya daidaita hanyoyin siginar rayuwa a cikin sel, kamar hanyar siginar furotin mai kunnawa AMP (AMPK). AMPK shine "sensor" na metabolism makamashin salula. Bayan urolithin A yana kunna AMPK, zai iya haifar da sel don canzawa daga anabolism zuwa catabolism, yin amfani da makamashi da abinci mai mahimmanci, don haka inganta aikin rayuwa gaba ɗaya.
Aikace-aikacen urolitin A baya iyakance ga filin likita. Har ila yau, a hankali yana samun kulawa a cikin kayan kiwon lafiya da kayan shafawa. An ƙara Urolithin A zuwa samfuran kiwon lafiya da yawa don haɓaka rigakafi, haɓaka yaduwar jini da haɓaka metabolism. Wadannan samfurori yawanci suna cikin nau'i na capsules, allunan ko ruwaye, dace da bukatun ƙungiyoyin mutane daban-daban.
A fannin kayan shafawa, urolithin A ana amfani da shi sosai a cikin samfuran kula da fata saboda sabuntawar tantanin halitta da abubuwan hana tsufa. Zai iya inganta yanayin jini a cikin fata kuma yana inganta haɓakar collagen, don haka inganta elasticity na fata da haske. Yawancin manyan samfuran kula da fata sun fara amfani da urolithin A a matsayin sinadari mai mahimmanci don ƙaddamar da maganin tsufa, gyare-gyare da kayan daɗaɗɗa don saduwa da abokan ciniki na neman kyakkyawar fata.
A ƙarshe, a matsayin abu mai haɓakawa tare da ayyuka da yawa, urolithin A ya nuna fa'idodin aikace-aikacen a fagagen magani, kula da lafiya da kyau. Tare da zurfafa binciken kimiyya, filin aikace-aikacen urolithin A zai ci gaba da fadadawa, yana ba da ƙarin zaɓuɓɓuka don lafiyar mutane da kyau.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Dec-12-2024
