5-Amino-1-methylquinolinium iodide(NNMTi) Lambar CAS:42464-96-0 98.0% tsarki minti | masana'antar ƙarin sinadaran
Sigogin Samfura
| Sunan samfurin | 5-Amino-1-methylquinolinium iodide(NNMTi) |
| Wani suna | NNMTi5-AMINO-1-METHYLQUINOLIN-1-IUM IODIDE 5-amino-1-methylquinolinium iodide 5-Amino-1-methylquinolin-1-iumiodide 1-methylquinolin-1-ium-5-amine; aiodide 5-Amino-1-methyl-1-quinolinium Iodide 5-Amino-1-mq iodide |
| Lambar CAS | 42464-96-0 |
| Tsarin kwayoyin halitta | C10H11IN2 |
| Nauyin kwayoyin halitta | 286.11 |
| Tsarkaka | 98.0% |
| Bayyanar | Ruwan kasa zuwa ja daga launin ruwan kasa mai kauri |
| shiryawa | 1kg/jaka, 25kg/ganga |
| Aikace-aikace | Kayan Abinci Mai Gina Jiki |
Gabatarwar samfur
An gano sabon enzyme na cytosolic nicotinamide N-methyltransferase (NNMT) don daidaita matakan abubuwan da suka riga suka fara nicotinamide da ake buƙata don biosynthesis na NAD+, saboda haka yana taka muhimmiyar rawa wajen daidaita hanyar ceto ta NAD+ da metabolism na ƙwayoyin halitta. Ana bayyana NNMT a cikin tsokar ƙashi, kuma bayyanarsa tana ƙaruwa a hankali tare da tsufa na kyallen tsoka. Abu mafi mahimmanci, NNMT babban ɓangare ne na siginar bayyanar kwayar halittar sarcopenic, kuma yawan bayyanarsa na iya haifar da raguwa mai yawa a matakan NAD+ da raguwar yawan tsoka, ƙarfi, da aikin da ke tare da tsufa. Maganin beraye tsofaffi tare da ƙaramin ƙwayar NNMT inhibitor (NNMTi) ya haɓaka haɓakar, haɗuwa, da ƙarfin sake farfaɗowa na muSCs, don haka inganta aikin tsokar ƙashi. An sami irin wannan sakamako a cikin vitro ta amfani da ƙwayoyin C2C12, waɗanda suke kama da muSCs sosai, inda maganin NNMTi ya haɓaka bambancin myoblast kuma ya goyi bayan canje-canje na metabolism a cikin metabolites na ƙwayoyin halitta da ke da alaƙa da hanyar ceto ta NAD +.
NNMT wani enzyme ne da ake yawan amfani da shi yayin tsufar tsokar ƙashi kuma yana da alaƙa da lalacewar hanyar NAD+, aikin sirtuin1 mara tsari, da kuma ƙaruwar tsufar ƙwayoyin tsoka. NNMT wani enzyme ne na rayuwa wanda ke haɓaka methylation na nicotinamide (NAM) ta amfani da S-adenosylmethionine (SAM) na duniya, yana haɗa yanayin metabolism na tantanin halitta zuwa daidaiton methylation da matakan NAD+ na cikin ƙwayoyin halitta. NNMT yana bayyana sosai a cikin hanta da kyallen mai, da kuma a cikin yanayin cututtuka wanda ke da alaƙa da ƙaruwar buƙatun metabolism, kamar wasu cututtukan hanta mai kitse da ciwon suga. NNMT yana shiga cikin nau'ikan hanyoyin bambance-bambance daban-daban, gami da canjin ƙwayoyin halittar ɗan adam na ɗan adam zuwa ga girma, myogenesis, da canjin epithelial da neuromesenchymal a cikin cututtuka daban-daban. Ana tsara bayyanar NNMT ta hanyar nama-da-wane maimakon ta hanyar tsari mai faɗi.
Fasali
(1) Tsafta mai yawa: NNMTi na iya samun samfuran tsafta mai yawa ta hanyar ingantattun hanyoyin samarwa. Tsafta mai yawa yana nufin ingantaccen samuwar halittu.
(2) Manufa: NNMTi ta musamman tana kai hari ga enzyme na NNMT kuma tana iya hana ayyukanta yadda ya kamata, ta haka tana shafar hanyar metabolism na nicotinamide.
(3) Kwanciyar hankali: NNMTi yana da kyakkyawan kwanciyar hankali kuma yana iya kiyaye aikinsa da tasirinsa a ƙarƙashin yanayi daban-daban da yanayin ajiya.
(4)Halayen ci gaba: Saboda halaye daban-daban na NNMTi, ci gabanta ya sami kulawa sosai kuma yana da faffadan bincike da damar amfani.
Aikace-aikace
NNMTi (CAS 42464-96-0) wani mai hana nicotinamide N-methyltransferase (NNMT) ne, wani mai hana mai ƙarfi (IC50=1.2 μM) na nicotinamide N-methyltransferase (NNMT) wanda ke haɓaka bambance-bambancen myoblast. NNMti yana ɗaurewa da ragowar wuraren da ke ɗaure substrate na NNMT. NNMTi yana haɓaka bambance-bambancen myoblast a cikin vitro kuma yana haɓaka haɗuwa da ƙwayoyin tsoka da sake farfaɗowa a cikin tsofaffin beraye. NNMT wani muhimmin enzyme ne na cytosolic biotransformation wanda ke haɓaka N-methylation na xenobiotics na ciki da na waje. Idan aka kwatanta da maye gurbin abinci mai laushi kaɗai, maganin NNMT tare da maye gurbin abinci mai laushi yana hanzarta haɓaka asarar kitse a jiki, ƙara yawan kitse na jiki gaba ɗaya zuwa rabon nauyin jiki, rage nauyin nama na hanta epididymal fari, rage ajiyar kitsen hanta, da inganta steatosis na hanta. Bugu da ƙari, NNMTi na iya ƙara ƙarfi da haɓaka ƙarfin sake farfaɗowa na tsoka mai tsufa, wanda zai iya zama da amfani ga maganin sarcopenia.
