Agomelatine foda manufacturer CAS No.: 138112-76-2 99% tsarki min. don kari kayan abinci
Bidiyon Samfura
Ma'aunin Samfura
| Sunan samfur | Agomelatine |
| Wani suna | N-[2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N-[2- (7methoxynaphthalen-1-yl) ethyl] acetamide |
| CAS No. | 138112-76-2 |
| Tsarin kwayoyin halitta | Saukewa: C15H17NO2 |
| Nauyin kwayoyin halitta | 243.3082 |
| Tsafta | 99.0% |
| Bayyanar | Farin foda |
| Shiryawa | 1kg/bag 25kg/drum |
| Aikace-aikace | Danyen kayan kiwon lafiya |
Gabatarwar samfur
An fara kaddamar da Agomelatine a Turai a cikin 2009 kuma yanzu an amince da amfani da shi a cikin fiye da kasashe 70. Ba kamar na gargajiya antidepressants, agomelatine yana aiki ta hanyar kai hari ga melatonin da masu karɓar serotonin a cikin kwakwalwa. Ta hanyar yin aiki azaman agonist a masu karɓar melatonin, agomelatine yana taimakawa daidaita yanayin bacci mai rugujewar sau da yawa hade da baƙin ciki. Wannan tsarin ba wai kawai yana taimakawa inganta ingancin barci ba amma yana taimakawa wajen dawo da rhythms na circadian na halitta. Bugu da ƙari, agomelatine yana aiki a matsayin mai adawa da wasu masu karɓa na serotonin (5-HT2C masu karɓa). Wannan aikin na musamman na dual a kaikaice yana haɓaka samuwar serotonin a cikin kwakwalwa, neurotransmitter da ke da alhakin daidaita yanayi. Ta hanyar daidaita matakan serotonin, agomelatine na iya yin aiki a matsayin ingantaccen maganin damuwa, kawar da bayyanar cututtuka kamar baƙin ciki, asarar sha'awa, jin laifi ko rashin amfani. Bugu da ƙari, agomelatine na iya ba da wasu fa'idodi. Bincike ya nuna yana iya taimakawa wajen inganta aikin fahimi Bincike yana nuna yiwuwar haɓaka ƙwaƙwalwar ajiya, hankali, da aikin zartarwa, yana mai da shi yanki mai ban sha'awa don bincike na gaba.
Siffar
(1) Babban tsabta: Agomelatine na iya samun samfurori masu tsabta ta hanyar tsaftace hanyoyin samarwa. Babban tsabta yana nufin mafi kyawun yanayin rayuwa da ƙarancin halayen halayen.
(2) Tsaro: Babban aminci, 'yan mummunan halayen.
(3) Kwanciyar hankali: Agomelatine yana da kwanciyar hankali mai kyau kuma yana iya kula da ayyukansa da tasiri a ƙarƙashin yanayi daban-daban da yanayin ajiya.
Aikace-aikace
Agomelatine antidepressant ne kuma melatonin antagonist. Yana rage alamun damuwa ta hanyar daidaita masu karɓa na melatonin MT1 (yana rage siginar ƙararrawa na cortical) da MT2 masu karɓa (cikadian sleep rhythm) da matakan serotonin. Ana ɗaukar shi da daddare, yana kwaikwayi yanayin yanayin sakin melatonin kuma yana iya inganta ingancin bacci sosai. Tsarin aikinsa yana karya ta hanyar tsarin watsa monoamine na gargajiya. Yana kunna masu karɓar melatonin MT1 da MT2 kuma yana adawa da masu karɓar 5-HT2C. Yana inganta ingancin barci, yana maido da rhythm na halitta, kuma yana da tasirin antidepressant; tsakanin su, ta hanyar ƙin karɓar masu karɓa na 5-HT2C akan membrane postsynapti, yana iya ƙara sakin DA da NE a cikin cortex na prefrontal, yana haifar da sakamako na antidepressant. Lokacin da MT agonism da 5-HT2C receptor antagonism suka kasance tare, ana iya samar da sakamako na musamman na synergistic, inganta sakin ƙarin DA da NE a cikin yankin kwakwalwa na PFC, yana ƙara ƙarfafa tasirin antidepressant. Bugu da ƙari, agomelatine na iya inganta sakin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa a cikin PFC da kuma toshe damuwa da aka haifar da sakin glutamate a cikin yankin kwakwalwar amygdala.
