Agomelatine foda manufacturer CAS No.: 138112-76-2 99% tsarki min.don kari kayan abinci
Sigar Samfura
| Sunan samfur | Agomelatine |
| Wani suna | N-[2- (7-Methoxy-1-naphthyl) ethyl] acetamide; N-[2- (7methoxynaphthalen-1-yl) ethyl] acetamide |
| CAS No. | 138112-76-2 |
| Tsarin kwayoyin halitta | Saukewa: C15H17NO2 |
| Nauyin kwayoyin halitta | 243.3082 |
| Tsafta | 99.0% |
| Bayyanar | Farin foda |
| Shiryawa | 1kg/bag 25kg/drum |
| Aikace-aikace | Danyen kayan kiwon lafiya |
Gabatarwar samfur
Agomelatine sabon nau'in antidepressant ne.Tsarin aikinsa yana karya ta hanyar tsarin watsawa na monoamine na gargajiya.Yana kunna masu karɓar melatonin, MT1 da MT2, kuma yana adawa da masu karɓar 5-HT2C.Zai iya inganta ingancin barci kuma ya dawo da hawan ilimin halitta yayin da yake da tasirin antidepressant;tsakanin su, ta hanyar ƙin karɓar mai karɓar 5-HT2C na membrane postsynapti, yana iya ƙara sakin DA da NE a cikin cortex na prefrontal kuma yana taka rawar antidepressant.Lokacin da MT agonism da 5-HT2C receptor antagonism sun kasance a lokaci guda, ana iya samar da sakamako na musamman na synergistic don inganta sakin ƙarin DA da NE a cikin yankin kwakwalwa na PFC, yana ƙara ƙarfafa tasirin antidepressant.Bugu da ƙari, agomelatine kuma zai iya inganta sakin ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwar ƙwaƙwalwa a cikin PFC kuma ya toshe damuwa da aka haifar da sakin glutamate a cikin yankin kwakwalwar amygdala.
Siffar
(1) Dual regulation: Ba wai kawai zai iya daidaita sakin melatonin ba, har ma yana daidaita sakin 5-hydroxytryptamine da norepinephrine, don haka yana taka rawa wajen daidaita yanayi, barci, zafi da sauransu.
(2) Inganta barci: Agomelatine shine zai iya inganta rashin barci ba tare da haifar da barci ko suma ba.
(3) Inganta aikin haɓakawa: Agomelatine na iya inganta aikin haɓaka ta hanyar haɓaka neuroplasticity a cikin hippocampus.
(4) Babban aminci: Idan aka kwatanta da sauran magungunan rage damuwa, miyagun ƙwayoyi yana da ƙananan sakamako masu illa lokacin da ake magance damuwa, kuma ba zai shafi aikin jima'i da nauyin jiki ba.
Aikace-aikace
Agomelatine na maganin ciwon kai wanda kuma shine melatonin antagonist.Yana rage alamun damuwa ta hanyar daidaita matakan melatonin MT1 masu karɓa (don rage siginar ƙararrawa na cortical) da MT2 masu karɓa (zuwa circadian rhythms na barci) da serotonin.Ɗaukar da daddare don kwaikwayi yanayin yanayin sakin melatonin, yana iya inganta ingancin bacci sosai.
