Mai ƙera foda na Agomelatine CAS No.: 138112-76-2 Tsarkakakken kashi 99% na mintuna don ƙarin sinadaran
Bidiyon Samfura
Sigogin Samfura
| Sunan samfurin | Agomelatin |
| Wani suna | N-[2-(7-Methoxy-1-naphthyl)ethyl]acetamide;N-[2-(7methoxynaphthalen-1-yl)ethyl]acetamide |
| Lambar CAS | 138112-76-2 |
| Tsarin kwayoyin halitta | C15H17NO2 |
| Nauyin kwayoyin halitta | 243.3082 |
| Tsarkaka | 99.0% |
| Bayyanar | Foda fari |
| shiryawa | 1kg/jaka 25kg/ganga |
| Aikace-aikace | Kayan amfanin gona na samfurin lafiya |
Gabatarwar samfur
An fara ƙaddamar da Agomelatine a Turai a shekara ta 2009 kuma yanzu an amince da amfani da shi a ƙasashe sama da 70. Ba kamar magungunan rage radadi na gargajiya ba, agomelatine yana aiki ta hanyar niyya ga masu karɓar melatonin da serotonin a cikin kwakwalwa. Ta hanyar yin aiki a matsayin mai hana radadi ga masu karɓar melatonin, agomelatine yana taimakawa wajen daidaita yanayin barci da ke damun waɗanda galibi ke da alaƙa da baƙin ciki. Wannan hanyar ba wai kawai tana taimakawa wajen inganta ingancin barci ba, har ma tana taimakawa wajen dawo da yanayin circadian na halitta. Bugu da ƙari, agomelatine yana aiki a matsayin mai hana radadi a wasu masu karɓar serotonin (masu karɓar 5-HT2C). Wannan aiki na musamman mai aiki biyu yana haɓaka samuwar serotonin a cikin kwakwalwa, wani neurotransmitter mai alhakin daidaita yanayi. Ta hanyar daidaita matakan serotonin, agomelatine na iya aiki a matsayin mai hana radadi mai tasiri, yana rage alamun kamar baƙin ciki, rashin sha'awa, jin laifi ko rashin amfani. Bugu da ƙari, agomelatine na iya samar da wasu fa'idodi. Bincike ya nuna cewa yana iya taimakawa wajen inganta aikin fahimta. Bincike ya nuna yuwuwarsa na haɓaka ƙwaƙwalwa, hankali, da aikin zartarwa, yana mai da shi yanki mai ban sha'awa don bincike na gaba.
Fasali
(1) Tsafta mai yawa: Agomelatine na iya samun samfuran tsafta mai yawa ta hanyar tace hanyoyin samar da kayayyaki. Tsafta mai yawa yana nufin ingantaccen samuwar halittu da ƙarancin halayen da ba su da kyau.
(2) Tsaro: Babban aminci, ƙarancin halayen da ba su dace ba.
(3) Kwanciyar hankali: Agomelatine yana da kyakkyawan kwanciyar hankali kuma yana iya kiyaye aikinsa da tasirinsa a ƙarƙashin yanayi daban-daban da yanayin ajiya.
Aikace-aikace
Agomelatine magani ne mai rage damuwa da kuma maganin hana melatonin. Yana rage alamun damuwa ta hanyar daidaita masu karɓar melatonin MT1 (yana rage siginar ƙararrawa ta cortical) da masu karɓar MT2 (ƙaramin barci na circadian) da matakan serotonin. Ana shan sa da daddare, yana kwaikwayon yanayin sakin melatonin kuma yana iya inganta ingancin barci sosai. Tsarin aikinsa yana ratsa tsarin watsawa na monoamine na gargajiya. Yana kunna masu karɓar melatonin MT1 da MT2 kuma yana hana masu karɓar 5-HT2C. Yana inganta ingancin barci, yana dawo da tsarin halittu, kuma yana da tasirin rage damuwa; daga cikinsu, ta hanyar hana masu karɓar 5-HT2C akan membrane na postsynaptic, yana iya ƙara sakin DA da NE a cikin prefrontal cortex, yana haifar da tasirin rage damuwa. Lokacin da MT agonism da 5-HT2C receptor suka haɗu, ana iya samar da wani tasiri na musamman na haɗin gwiwa, wanda ke haɓaka sakin ƙarin DA da NE a yankin kwakwalwa na PFC, yana ƙara ƙarfafa tasirin rage damuwa. Bugu da ƙari, agomelatine na iya haɓaka sakin abubuwan da ke haifar da neurotrophic a cikin PFC da kuma toshe sakin glutamate da damuwa ke haifarwa a yankin kwakwalwa na amygdala.
