NAD + (Beta-Nicotinamide Adenine Dinucleotide) wani coenzyme ne da aka samo a cikin dukkanin sel masu rai kuma yana da mahimmanci ga nau'o'in tsarin ilimin halitta, ciki har da samar da makamashi da gyaran DNA. Yayin da muke tsufa, matakan NAD+ na mu suna raguwa, yana haifar da matsalolin lafiya da yawa. Don magance wannan matsala, mutane da yawa sun juya zuwa NAD + kari a cikin foda. Duk da haka, tare da zaɓuɓɓuka da yawa a can, ƙayyade abin da NAD + foda ya fi dacewa a gare ku zai iya zama kalubale. Zaɓin mafi kyawun NAD + foda yana buƙatar yin la'akari da hankali na tsabta, bioavailability, sashi, tsabta, da ra'ayoyin abokin ciniki. Ta hanyar ba da fifiko ga waɗannan abubuwan, za ku iya yanke shawarar da aka sani kuma ku zaɓi NAD + foda mai inganci wanda ke tallafawa lafiyar ku da lafiyar ku.
NAD yana faruwa ta dabi'a a cikin sel,da farko a cikin cytoplasm da mitochondria, duk da haka, matakan halitta na NAD sun ragu yayin da muke tsufa (kowane shekaru 20, a gaskiya), yana haifar da tasirin al'ada na tsufa, Irin su rage yawan matakan makamashi da ƙara yawan ciwo da ciwo. Menene ƙari, raguwa da ke da alaƙa da tsufa a cikin NAD yana da alaƙa da wasu cututtukan da ke da alaƙa da shekaru, kamar su kansa, raguwar fahimi, da rauni.
NAD + ba hormone bane, coenzyme ne. NAD + na iya inganta ikon DNA don gyara kansa, tsawaita tsawon rayuwa ta hanyar juyar da raguwar mitochondria, da kare DNA da lalacewar mitochondrial. Kuma zai iya inganta zaman lafiyar chromosome. NAD+ kuma ana kiranta da "kwayoyin mu'ujiza" wanda ke dawo da kuma kula da lafiyar tantanin halitta. A cikin nazarin dabbobi, an tabbatar da cewa yana da ƙarfi mai ƙarfi don magance cututtuka iri-iri kamar cututtukan zuciya, ciwon sukari, cutar Alzheimer, da kiba.
NAD + yana shiga cikin nau'ikan halayen biochemical a cikin sel, kamar glycolysis, fatty acid oxidation, tricarboxylic acid cycle, sarkar numfashi, da sauransu. Sauran kwayoyin halitta, irin su NADH da FAD, don kiyaye ma'auni na redox na cikin salula. NAD + yana taka muhimmiyar rawa wajen samar da makamashi ta salula, kariya ta radical, gyaran DNA, da sigina.
Bugu da kari, NAD+ shima yana da alaƙa da tsufa, kuma matakansa suna raguwa da shekaru. Sabili da haka, kiyaye matakan NAD + yana taka muhimmiyar rawa wajen jinkirta tsufa, haɓaka makamashi, inganta gyaran sel, inganta aikin fahimi, da daidaita tsarin rayuwa.
Musamman ma, tsufa yana tare da raguwar ci gaba a cikin nama da matakan NAD + na salula a cikin nau'ikan kwayoyin halitta iri-iri, gami da rodents da mutane.
Sabili da haka, lokacin da aka sake cika abun ciki na NAD + a cikin jiki na iya jinkirta tsufa da tabbatar da lafiya. Idan kuna son shekaru su zama lamba kawai, ƙara NAD+ da wuri-wuri don sa ku ƙarami daga ciki.
Matakan NAD+ suna raguwa da shekaru, musamman saboda yawan samar da shi ba zai iya ci gaba da yawan amfani da shi ba.
Yawancin karatu sun nuna cewa raguwar matakan NAD + yana da alaƙa da yawancin cututtukan da suka shafi tsufa, gami da raguwar fahimi, kumburi, ciwon daji, cututtukan rayuwa, sarcopenia, cututtukan neurodegenerative, da sauransu.
Wannan shine dalilin da ya sa muke buƙatar ƙarin NAD+. Kamar dai nau'in collagen ɗin mu na 3, kullum ana ɓacewa.
NAD + na iya tsayayya da tsufa. Menene ka'idar da ke tattare da shi?
nad+ yana kunna aikin gyaran kwayoyin halittar parp1
Taimakawa gyaran DNA Ɗaya daga cikin abubuwan da ke haifar da tsufa shine lalacewar DNA. Farin gashin ku, ovarian da sauran gabobin gabobi, duk suna da alaƙa da lalacewar DNA. Tsayawa a makara da damuwa zai kara lalata DNA.
Nazarin ya gano cewa NAD + yana taimakawa wajen kunna kwayar halittar PARP1 (wanda ke aiki a matsayin mai amsawa na farko don gano lalacewar DNA sannan kuma ya inganta zaɓin hanyoyin gyarawa. PARP1 yana haifar da lalata tsarin chromatin ta hanyar ADP ribosylation na histones, kuma yana shiga cikin DNA daban-daban. Abubuwan gyare-gyare suna hulɗa tare da gyara su, ta haka ne inganta aikin gyaran gyare-gyare), ta haka ne ke gyara lalacewar DNA da inganta ƙaddamar da canje-canje na rayuwa.
A taƙaice, NAD + na iya yin tasiri kai tsaye da kai tsaye akan yawancin mahimman ayyukan salula, gami da hanyoyin rayuwa, gyaran DNA, gyaran gyare-gyaren chromatin, yanayin salon salula, aikin ƙwayoyin cuta, da sauransu, don haka yana rage saurin tsufa na ɗan adam.
NAD+ shine gajartawar Ingilishi na Nicotinamide adenine dinucleotide. Cikakken sunansa a cikin Sinanci shine nicotinamide adenine dinucleotide, ko Coenzyme I a takaice. A matsayin coenzyme wanda ke watsa ions hydrogen, NAD + yana taka rawa a yawancin al'amuran metabolism na mutum, ciki har da glycolysis, Gluconeogenesis, tricarboxylic acid cycle, da sauransu. ta NAD + suna da alaƙa da tsufa, cututtuka na rayuwa, neuropathy da ciwon daji, ciki har da daidaitawar homeostasis cell, sirtuins da aka sani da "kwayoyin rayuwa mai tsawo", gyaran DNA, PARPs sunadaran iyali da ke da alaka da necroptosis da CD38 wanda ke taimakawa wajen siginar calcium.
Maganin tsufa
Tsufa na nufin tsarin da ƙwayoyin sel ba za su daina rarrabuwa ba. Lalacewar DNA da ba a gyara ba ko damuwa ta salula na iya haifar da jin daɗi. An bayyana tsufa gabaɗaya azaman tsarin lalata ayyukan ilimin lissafi a hankali tare da shekaru; bayyanar cututtuka na waje shine canje-canje na jiki wanda ke haifar da asarar tsokoki da kasusuwa, kuma bayyanar cututtuka na ciki sun rage yawan ƙwayar basal da aikin rigakafi.
Masana kimiyya sun yi nazari kan mutanen da suka dade suna rayuwa, kuma sakamakon bincike ya nuna cewa akwai kwayar halittar da ke da alaka da tsawon rai a cikin wadanda suka dade suna rayuwa - wato "Sirtuins gene". Wannan kwayar halitta za ta shiga cikin gyaran tsarin samar da makamashi na jiki da kwafin DNA don kiyaye mutunci da kwanciyar hankali na kwayar halitta, cire ƙwayoyin tsufa, inganta tsarin rigakafi ta hanyar maganin kumburi da antioxidant, da jinkirta tsufa na kwayoyin halitta.
Iyakar abin da aka yi niyya kawai na kwayoyin rayuwa na tsawon rai "Sirtuins" -NAD+
NAD + yana da mahimmanci don kiyaye lafiyar jiki da daidaito. Metabolism, redox, kulawar DNA da gyarawa, kwanciyar hankali na kwayoyin halitta, tsarin epigenetic, da dai sauransu duk suna buƙatar sa hannu na NAD +.
NAD+ yana kula da sadarwar sinadarai tsakanin tsakiya da mitochondria, kuma raunin sadarwa shine muhimmin dalilin tsufa na salula.
NAD + na iya cire karuwar adadin lambobin DNA na kuskure yayin metabolism na sel, kula da maganganun al'ada na al'ada, kula da aikin yau da kullun na sel, da rage tsufa na ƙwayoyin ɗan adam.
Gyara lalacewar DNA
NAD + wani muhimmin abu ne don gyaran enzyme na DNA na PARP, wanda ke da tasiri mai mahimmanci akan gyaran DNA, maganganun kwayoyin halitta, ci gaban kwayar halitta, rayuwar tantanin halitta, sake gina chromosome, da kwanciyar hankali.
Kunna furotin na tsawon rai
Sirtuins galibi ana kiran su dangin furotin na tsawon rai kuma suna taka muhimmiyar rawa a cikin ayyukan tantanin halitta, kamar kumburi, haɓakar tantanin halitta, rhythm na circadian, metabolism makamashi, aikin neuronal, da juriya, kuma NAD + shine muhimmin enzyme don haɓakar sunadaran tsawon rai. . Yana kunna duk sunadaran 7 na tsawon rai a cikin jikin mutum, yana taka muhimmiyar rawa a juriya ta salon salula, metabolism makamashi, hana maye gurbi, apoptosis da tsufa.
Samar da makamashi
Yana haɓaka samar da fiye da 95% na makamashin da ake buƙata don ayyukan rayuwa. Mitochondria a cikin sel ɗan adam sune tsire-tsire masu ƙarfi na sel. NAD + muhimmin coenzyme ne a cikin mitochondria don samar da kwayoyin makamashi ATP, yana canza abubuwan gina jiki zuwa makamashin da jikin dan adam ke bukata.
Haɓaka farfadowar jigon jini da kula da elasticity na jini
Tasoshin jini sune nama masu mahimmanci don ayyukan rayuwa. Yayin da muke tsufa, jijiyoyin jini a hankali suna rasa sassaucin su kuma suna daɗaɗa ƙarfi, kauri, da kunkuntar, suna haifar da "arteriosclerosis." NAD + na iya haɓaka aikin elastin a cikin tasoshin jini, ta haka ne ke kiyaye elasticity na tasoshin jini da kuma kula da lafiyar jijiyoyin jini.
Inganta metabolism
Metabolism shine jimlar halayen halayen sinadarai iri-iri a cikin jiki. Jiki zai ci gaba da musayar kwayoyin halitta da makamashi. Lokacin da wannan musayar ya tsaya, rayuwar jiki ma za ta ƙare.
Farfesa Anthony tare da tawagarsa na bincike a Jami'ar California, Amurka, sun gano cewa NAD + na iya inganta yadda ya kamata don rage raguwar ƙwayoyin sel da ke da alaƙa da tsufa, ta yadda za a inganta lafiyar mutane da kuma tsawaita rayuwa.
Kare lafiyar zuciya
Zuciya ita ce mafi mahimmancin sashin jikin ɗan adam, kuma matakin NAD + a cikin jiki yana taka muhimmiyar rawa wajen kiyaye aikin zuciya na yau da kullun. Ragewar NAD + na iya kasancewa da alaƙa da cututtukan cututtukan cututtukan zuciya da yawa, kuma yawancin karatun asali sun kuma tabbatar da tasirin ƙarin NAD + akan cututtukan zuciya.
Hana cututtukan zuciya da jijiyoyin jini
Bincike ya nuna cewa kusan dukkanin nau'ikan sirtuins guda bakwai (SIRT1-SIRT7) suna da alaƙa da faruwar cututtukan zuciya. Ana ɗaukar Sirtuins a matsayin makasudin agonist don maganin cututtukan zuciya, musamman SIRT1.
NAD + shine kawai madaidaicin madaidaicin Sirtuins. Canjin lokaci na NAD + ga jikin ɗan adam zai iya kunna cikakken aikin kowane nau'in Sirtuins, ta haka yana kare lafiyar zuciya da kuma hana cututtukan zuciya.
Inganta girman gashi
Babban abin da ke haifar da asarar gashi shine asarar gashi ga mahaifiyar cell, kuma rashin lafiyar mahaifiyar cell shine saboda matakin NAD+ a jikin mutum yana raguwa. Kwayoyin uwar gashi ba su da isasshen ATP don aiwatar da haɗin furotin gashi, don haka rasa ƙarfin su kuma yana haifar da asarar gashi. Don haka, ƙarin NAD + na iya ƙarfafa tsarin acid ɗin kuma ya samar da ATP, ta yadda sel mahaifiyar gashi suna da isasshen ikon samar da furotin gashi, don haka inganta asarar gashi.
NAD+ maganin kwayoyin halitta
Yayin da tsufa ya karu, matakin NAD + (Coenzyme I) a cikin jiki zai sauke wani dutse, wanda kai tsaye yana haifar da aikin jiki da tsufa na cell! Bayan shekaru na tsakiya, matakin NAD + a cikin jikin mutum yana raguwa kowace shekara. Lokacin da yake da shekaru 50, matakin NAD + a cikin jiki shine rabin abin da ke cikin shekaru 20. Ta hanyar shekaru 80, matakan NAD + kawai kusan 1% na abin da suke a shekaru 20.
Don haka, ta yaya NAD + foda ya bambanta da sauran kari akan kasuwa? Bari mu dubi wasu mahimman abubuwan da ya kamata mu yi la'akari:
1. Samuwar halittu:
Ɗaya daga cikin manyan bambance-bambance tsakanin NAD + foda da sauran abubuwan kari shine bioavailability. NAD + foda yana ɗaukar jiki cikin sauƙi kuma yana amfani da coenzymes da kyau. Sabanin haka, wasu abubuwan kari na iya samun ƙananan bioavailability, ma'ana jiki bazai iya sha da amfani da kayan aikin da ya dace ba.
2. Tsarin aiki:
NAD + foda yana aiki ta hanyar sake cika matakan NAD + a cikin jiki, don haka yana tallafawa ayyuka daban-daban na salula. Sauran abubuwan kari na iya samun hanyoyin aiki daban-daban, suna niyya takamaiman hanyoyi ko tsarin a cikin jiki. Fahimtar takamaiman hanyoyin aiwatar da abubuwan kari daban-daban na iya taimaka muku sanin waɗanne ne suka fi dacewa don buƙatun ku.
3. Bincike da shaida:
Lokacin yin la'akari da kowane kari, yana da mahimmanci a sake duba binciken da ke akwai da shaidar da ke goyan bayan ingancinta da amincinta. NAD + foda ya kasance batun binciken da yawa, yana nuna yiwuwar amfani da lafiyar salula da kuma tsawon rai. A wani bangaren kuma, wasu abubuwan kari na iya samun iyakataccen bincike don tallafawa da'awarsu. Fahimtar shaidar kimiyya da ke bayan kari na iya taimaka muku yanke shawara mai zurfi game da amfani da shi.
4. Bukatu da manufofin mutum:
Daga ƙarshe, yanke shawarar yin amfani da NAD + foda ko wasu kari ya kamata ya dogara da bukatun ku da burin lafiyar ku. Yi la'akari da tuntuɓar ƙwararrun kiwon lafiya ko ƙwararren masanin abinci mai gina jiki don sanin waɗanne kari zai iya zama mafi amfani a gare ku. Abubuwa kamar shekaru, salon rayuwa, da yanayin kiwon lafiya da ake da su duk na iya taka rawa wajen tantance mafi dacewa tsarin kari.
NAD +, masana kimiyya sun shafe shekaru 100 suna nazarin shi. NAD+ ba sabon bincike ba ne, amma wani abu ne da aka yi nazari sama da shekaru 100.
An fara gano NAD+ a cikin 1904 ta Masanin kimiyyar halittu na Burtaniya Sir Arthur Harden, wanda daga baya ya ci kyautar Nobel a Chemistry a 1929.
A cikin 1920, Hans von Euler-Chelpin ya ware kuma ya tsarkake NAD+ a karon farko kuma ya gano tsarinsa na dinucleotide, sannan ya lashe kyautar Nobel a Chemistry a 1929.
A cikin 1930, Otto Warburg ya fara gano mahimmin rawar NAD + a matsayin coenzyme a cikin kayan abu da makamashi, kuma daga baya ya sami lambar yabo ta Nobel a fannin likitanci a 1931.
A cikin 1980, George Birkmayer, farfesa a Sashen Kimiyyar Kiwon Lafiyar Kiwon Lafiyar Kiwon Lafiyar Jama'a a Jami'ar Graz a Ostiriya, ya fara neman rage NAD+ don maganin cututtuka.
A cikin 2012, ƙungiyar bincike na Leonard Guarente, ƙungiyar bincike na mashahurin masanin kimiyyar lissafi Stephen L. Helfand, da ƙungiyar bincike na Haim Y. Cohen bi da bi sun gano cewa NAD + na iya tsawaita sandunan Caenorhabditis elegans. Tsawon rayuwar nematodes ya kusan kusan kashi 50%, yana iya tsawaita rayuwar kudaje na 'ya'yan itace da kusan 10% -20%, kuma yana iya tsawaita rayuwar berayen da fiye da 10%.
Binciken masana kimiyya da bincike kan rayuwa ana sabunta su akai-akai kuma ana maimaita su akai-akai. A cikin Disamba 2013, David Sinclair, farfesa a fannin ilimin halittu a Jami'ar Harvard, ya buga "Ƙarin NAD tare da NAD" a cikin babbar mujallar ilimi ta duniya "Cell". "Bayan mako guda na haɓaka NAD tare da wakili, an ƙara tsawon rayuwar beraye da 30%." Sakamakon binciken ya bayyana a karon farko cewa abubuwan da ake amfani da su na NAD + na iya canza tsufa sosai da kuma tsawaita tsawon rayuwa. Wannan binciken ya gigita duniya kuma ya buɗe hanya don shahara don abubuwan NAD azaman abubuwan hana tsufa. .
Tare da wannan binciken mai ban mamaki, NAD + ya kafa haɗin da ba za a iya raba shi da anti-tsufa ba. A cikin 'yan shekarun nan, bincike kan NAD + ya kusan mamaye manyan mujallu na ilimi na SCI kamar Kimiyya, Nature, da Kwayoyin Halitta, ya zama gano mafi ban sha'awa a cikin al'ummar likitanci. An ce wannan mataki ne mai cike da tarihi da dan Adam ya dauka a yunkurin yaki da tsufa da tsawaita rayuwa.
1. Bincika sunan tambarin da bayyana gaskiya
Lokacin yin la'akari da takamaiman nau'in foda na NAD +, yana da daraja bincika sunan kamfanin da bayyana gaskiya. Nemo samfuran da ke ba da fifikon bayyana gaskiya a cikin hanyoyin samar da su da masana'anta. Mashahuran samfuran za su ba da cikakken bayani game da NAD + foda mai narkewa, gami da ingancin albarkatun ƙasa da ƙa'idodin masana'anta da suke bi. Bugu da ƙari, nemo bita na abokin ciniki da kuma shaida don auna gamsuwar sauran masu amfani gabaɗaya da ƙwarewar samfuran samfuran.
2. Yi la'akari da tsabtar NAD + foda
Tsafta shine maɓalli mai mahimmanci lokacin zabar alamar NAD + foda. Kyakkyawan NAD + foda ya kamata ya kasance ba tare da gurɓatawa da masu cikawa ba, yana tabbatar da samun samfur mai tsabta da inganci. Nemo samfuran da ke gudanar da gwaji na ɓangare na uku don tabbatar da tsabtar foda na NAD+. Gwajin ɓangare na uku yana ba da ƙarin tabbaci cewa samfuran sun cika mafi girman ƙa'idodin tsabta kuma basu ƙunshi kowane abu mai cutarwa ba.
3. Yi la'akari da matakan masana'antu da ka'idojin inganci
Tsarin masana'antu yana taka muhimmiyar rawa a cikin ingancin NAD + foda. Zaɓi samfuran samfuran da ke bin tsauraran matakan sarrafa inganci kuma ku bi Kyawawan Ayyukan Masana'antu (GMP). Takaddun shaida na GMP yana tabbatar da cewa an samar da samfuran a cikin tsaftataccen muhalli da sarrafawa, rage haɗarin kamuwa da cuta da tabbatar da daidaiton inganci. Bugu da ƙari, tambaya game da sadaukarwar alamar don dorewa da ayyukan samar da ɗabi'a, saboda waɗannan abubuwan kuma za su iya yin la'akari da ingancin samfurin gaba ɗaya.
4. Yi la'akari da bioavailability da sha na NAD + foda
Bioavailability yana nufin ikon jiki don sha da amfani da abubuwan da ke aiki a cikin kari. Lokacin zabar alamar NAD + foda, la'akari da kasancewar samfurin. Nemo samfuran samfuran da ke amfani da tsarin isarwa na ci gaba ko fasaha don haɓaka haɓakar NAD+. Wannan na iya haɗawa da fasali irin su micronization ko encapsulation, wanda zai iya inganta haɓakar NAD + a cikin jiki, yana haɓaka tasirin sa.
5. Nemi binciken kimiyya da bincike na asibiti
Shahararrun samfuran NAD + foda yawanci suna ba da karatun kimiyya da na asibiti don tallafawa inganci da amincin samfuran su. Nemo samfuran da ke saka hannun jari a cikin bincike da haɓakawa, saboda wannan yana nuna sadaukarwar samar da inganci da samfuran tushen shaida. Tabbatar da ilimin kimiyya yana tabbatar da cewa NAD + foda ya yi gwajin gwaji da ƙima, yana ƙara tabbatar da ingancinsa da tsabta.
Suzhou Myland Pharm & Nutrition Inc. ya tsunduma cikin kasuwancin kari na sinadirai tun 1992. Shi ne kamfani na farko a kasar Sin da ya bunkasa da sayar da tsantsar irin innabi.
Tare da shekaru 30 na gwaninta da haɓaka ta hanyar fasaha mai zurfi da ingantaccen dabarun R&D, kamfanin ya haɓaka kewayon samfuran gasa kuma ya zama ƙarin ƙarin ilimin kimiyyar rayuwa, haɗin al'ada da kamfanin sabis na masana'antu.
Bugu da kari, Suzhou Myland Pharm & Nutrition Inc. kuma masana'anta ce mai rijista ta FDA. Abubuwan R&D na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma masu aiki da yawa kuma suna iya samar da sinadarai daga milligrams zuwa ton a sikelin, kuma suna bin ka'idodin ISO 9001 da ƙayyadaddun samarwa GMP.
Tambaya: Menene ƙarin NAD + ake amfani dashi?
A: NAD + kari ne na abinci mai gina jiki wanda ke haɓaka coenzyme NAD + (nicotinamide adenine dinucleotide). NAD + yana taka muhimmiyar rawa a cikin metabolism na makamashi da gyaran sel a cikin sel.
Tambaya: Shin abubuwan NAD + suna aiki da gaske?
A: Wasu bincike sun nuna karin NAD + na iya taimakawa inganta haɓakar makamashin salula da rage saurin tsufa.
Tambaya: Menene tushen abincin NAD +?
A: Abubuwan abinci na NAD + sun haɗa da nama, kifi, kayan kiwo, wake, goro da kayan lambu. Waɗannan abincin sun ƙunshi ƙarin niacinamide da niacin, waɗanda za a iya canza su zuwa NAD + a cikin jiki.
Tambaya: Ta yaya zan zaɓi ƙarin NAD+?
A: Lokacin zabar abubuwan NAD +, ana ba da shawarar fara neman shawara daga likita ko masanin abinci mai gina jiki don fahimtar bukatun ku na sinadirai da matsayin lafiyar ku. Bugu da ƙari, zaɓi alama mai suna, bincika kayan aikin samfur da sashi, kuma bi jagorar sashi akan abin da aka saka samfurin.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Agusta-05-2024
