NAD+ kuma ana kiransa coenzyme, kuma cikakken sunansa shine nicotinamide adenine dinucleotide. Yana da mahimmancin coenzyme a cikin zagayowar tricarboxylic acid. Yana haɓaka metabolism na sukari, mai, da amino acid, yana shiga cikin haɓakar kuzari, kuma yana shiga cikin dubban halayen kowane tantanin halitta. Yawancin bayanan gwaji sun nuna cewa NAD + yana da hannu sosai a cikin nau'o'in ayyukan ilimin lissafi na asali a cikin kwayoyin halitta, ta haka ne ke shiga cikin mahimman ayyukan salula irin su makamashin makamashi, gyaran DNA, gyare-gyaren kwayoyin halitta, kumburi, rhythms na halitta, da kuma juriya na damuwa.
Dangane da binciken da ya dace, matakin NAD + a cikin jikin mutum zai ragu da shekaru. Rage matakan NAD+ na iya haifar da raguwar ƙwayoyin cuta, asarar hangen nesa, kiba, raguwar aikin zuciya da sauran raguwar aiki. Don haka, yadda ake ƙara matakin NAD + a cikin jikin ɗan adam ya kasance koyaushe tambaya. Taken bincike mai zafi a cikin al'ummar likitanci.
Domin, yayin da muka tsufa, DNA lalacewa yana ƙaruwa. Yayin aikin gyaran DNA, buƙatar PARP1 yana ƙaruwa, aikin SIRT yana da iyaka, yawan amfani da NAD + yana ƙaruwa, kuma adadin NAD + yana raguwa.
Jikinmu yana da kusan sel tiriliyan 37. Kwayoyin dole ne su kammala yawancin "aiki" ko halayen salula - don kula da kansu. Kowace sel ɗin ku tiriliyan 37 ya dogara da NAD+ don yin aikin da yake gudana.
Yayin da yawan al’ummar duniya ke da shekaru, cututtuka masu alaka da tsufa irin su cutar Alzheimer, cututtukan zuciya, matsalolin haɗin gwiwa, barci, da matsalolin zuciya da jijiyoyin jini sun zama manyan cututtuka da ke barazana ga lafiyar ɗan adam.
NAD+ matakan suna raguwa tare da shekaru, bisa ma'auni daga samfuran fata na mutum:
Sakamakon aunawa ya nuna cewa yayin da shekaru ke ƙaruwa, NAD + a cikin jikin ɗan adam zai ragu a hankali. Don haka menene ke haifar da raguwar NAD+?
Babban abubuwan da ke haifar da raguwar NAD + sune: tsufa da karuwar bukatar NAD +, wanda ke haifar da raguwar matakan NAD + a cikin kyallen takarda da yawa, ciki har da hanta, tsokar kwarangwal, da kwakwalwa. Sakamakon raguwar, rashin aikin mitochondrial, damuwa na oxidative da ƙumburi ana tsammanin zai ba da gudummawa ga matsalolin kiwon lafiya da suka shafi shekaru, haifar da mummunan yanayi.
1. NAD + yana aiki a matsayin coenzyme a cikin mitochondria don inganta ma'auni na rayuwa, NAD + yana taka muhimmiyar rawa a cikin matakai na rayuwa irin su glycolysis, zagaye na TCA (aka Krebs sake zagayowar ko citric acid sake zagayowar) da kuma jigilar jigilar lantarki, shine yadda sel ke samun makamashi. Tsufa da abinci mai yawan kalori suna rage matakan NAD + a cikin jiki.
Nazarin ya nuna cewa a cikin tsofaffin beraye, shan abubuwan NAD + sun rage yawan cin abinci-ko kiba mai alaƙa da haɓaka ƙarfin motsa jiki. Bugu da ƙari, nazarin ya ma sauya tasirin ciwon sukari a cikin berayen mata, yana nuna sabbin dabaru don yaƙar cututtuka na rayuwa kamar kiba.
NAD+ yana ɗaure ga enzymes kuma yana canja wurin electrons tsakanin kwayoyin halitta. Electrons sune tushen makamashin salula. NAD+ yana aiki akan sel kamar yin cajin baturi. Lokacin da aka yi amfani da electrons, baturin ya mutu. A cikin sel, NAD + na iya haɓaka canja wurin lantarki da samar da makamashi ga sel. Ta wannan hanyar, NAD + na iya ragewa ko haɓaka ayyukan enzyme, haɓaka maganganun kwayoyin halitta da siginar tantanin halitta.
NAD + yana taimakawa sarrafa lalacewar DNA
Yayin da kwayoyin halitta suka tsufa, munanan abubuwan muhalli kamar radiation, gurɓataccen abu, da ƙarancin kwafin DNA na iya lalata DNA. Wannan yana daya daga cikin ka'idodin tsufa. Kusan dukkanin sel suna ɗauke da "na'urorin kwayoyin halitta" don gyara wannan lalacewa.
Wannan gyaran yana buƙatar NAD + da makamashi, don haka lalatawar DNA ta wuce kima tana cinye albarkatun salula masu mahimmanci. Ayyukan PARP, muhimmin furotin gyaran DNA, kuma ya dogara da NAD +. Tsufa na al'ada yana haifar da lalacewar DNA ta tarawa a cikin jiki, RARP yana ƙaruwa, sabili da haka adadin NAD + yana raguwa. Lalacewar DNA na mitochondrial a kowane mataki zai kara tsananta wannan raguwa.
2. NAD + yana shafar ayyukan kwayoyin halittar Sirtuins na tsawon rai kuma yana hana tsufa.
Sabbin kwayoyin halittar sirtuin da aka gano, wadanda kuma aka fi sani da “masu kula da kwayoyin halitta,” suna taka muhimmiyar rawa wajen kiyaye lafiyar kwayar halitta. Sirtuins iyali ne na enzymes da ke shiga cikin amsa damuwa ta salula da kuma lalacewa. Suna kuma shiga cikin ɓoyewar insulin, tsarin tsufa, da yanayin kiwon lafiya da suka shafi tsufa kamar cututtukan neurodegenerative da ciwon sukari.
NAD + shine man fetur wanda ke taimakawa sirtuins su kiyaye mutuncin kwayoyin halitta da inganta gyaran DNA. Kamar yadda mota ba za ta iya rayuwa ba tare da man fetur ba, Sirtuins yana buƙatar NAD + don kunnawa. Sakamako daga nazarin dabbobi sun nuna cewa haɓaka matakan NAD + a cikin jiki yana kunna sunadaran sirtuin kuma yana ƙara tsawon rayuwa a cikin yisti da mice.
3.Aikin zuciya
Haɓaka matakan NAD + yana kare zuciya kuma yana inganta aikin zuciya. Hawan jini na iya haifar da kara girman zuciya da toshewar arteries wanda zai iya haifar da bugun jini. Bayan sake cika matakin NAD + a cikin zuciya ta hanyar NAD + kari, an hana lalacewar zuciya da ke haifar da reperfusion. Sauran binciken sun nuna cewa kari na NAD + shima yana kare beraye daga girman girman zuciya.
4. Neurodegeneration
A cikin berayen da ke da cutar Alzheimer, haɓaka matakan NAD+ suna haɓaka aikin fahimi ta hanyar rage haɓakar sunadaran da ke lalata sadarwar kwakwalwa. Haɓaka matakan NAD+ kuma yana kare ƙwayoyin kwakwalwa daga mutuwa lokacin da babu isasshen jini da ke gudana zuwa kwakwalwa. NAD + ya bayyana yana da sabon alƙawari don karewa daga neurodegeneration da inganta ƙwaƙwalwar ajiya.
5. Tsarin rigakafi
Yayin da muke tsufa, tsarin garkuwar jikin mu yana raguwa kuma mun fi kamuwa da rashin lafiya. Binciken na baya-bayan nan ya nuna cewa matakan NAD + suna taka muhimmiyar rawa wajen daidaita martanin rigakafi da kumburi da rayuwar tantanin halitta yayin tsufa. Binciken yana nuna yiwuwar warkewar NAD + don rashin aikin rigakafi.
6. Daidaita metabolism
Yaƙi da lalacewar oxidative
NAD + na iya taimakawa jinkirta tsufa ta hanyar hana halayen kumburi, daidaita tsarin redox homeostasis na jiki, kare sel daga lalacewa, kiyaye ayyukan rayuwa na yau da kullun.
7. Taimakawa wajen danne ciwace-ciwace
Hakanan NAD + na iya hanawa da magance leukopenia ta hanyar radiotherapy da chemotherapy, haɓaka juriya na miyagun ƙwayoyi da ke haifar da dogon lokacin amfani da ƙwayoyin rigakafi na PD-1/PD-L1, da haɓaka haɓakar ƙwayoyin T cell da ikon kashe ƙari.
8. Inganta aikin ovarian
Matsayin NAD+ a cikin ovaries mata yana raguwa ta hanyar dogaro da shekaru. Ƙara abun ciki na NAD+ na iyainganta aikin mitochondrial ovarian,rage amsawar nau'in nau'in oxygen a cikin oocytes masu tsufa, da jinkirta tsufa na ovarian.
9. Inganta ingancin barci
NAD+ na iya inganta rashin daidaituwar rhythm circadian, inganta ingancin bacci, da haɓaka bacci ta hanyar daidaita agogon halitta.
Daban-daban gabobin jiki ba su wanzu da kansu. Haɗin kai da hulɗar da ke tsakanin su sun fi kusanci fiye da yadda muke zato. Ana iya jigilar abubuwan da tantanin halitta ya ɓoye zuwa kowane wuri a cikin jiki nan take; Ana watsa bayanan neurotransmitter da sauri kamar walƙiya. Fatar mu, a matsayin shingen dukkan jiki, ita ce layin gaba na fagen fama kuma ta fi dacewa da raunuka daban-daban. Lokacin da waɗannan raunuka ba za a iya gyara su ba, matsaloli daban-daban kamar tsufa za su biyo baya.
Na farko, tsarin tsufa na fata yana tare da jerin canje-canje a matakan salula da kwayoyin halitta, wanda za'a iya yadawa zuwa wasu kyallen takarda ko gabobin ta hanyoyi daban-daban.
Alal misali, yawan ƙwayoyin p16-tabbatacce (alamar tsufa) a cikin fata yana da alaƙa da alaƙa da alamun tsufa na ƙwayoyin rigakafi, wanda ke nufin cewa shekarun ilimin halitta na fata na iya yin hasashen tsufa na jiki zuwa wani matsayi. Bugu da ƙari, binciken ya gano cewa microbiota na fata na iya yin tsinkaya daidai da shekarun tarihin lokaci, yana kara tabbatar da kusanci tsakanin fata da tsarin tsufa.
Littattafan da suka gabata sun ba da rahoton cewa tsarin tsufa a tsakanin gabobin jiki daban-daban ba su daidaita ba, kuma fata na iya zama farkon gabobin da ke nuna alamun tsufa. Dangane da kusancin da ke tsakanin tsufa na fata da sauran gabobin jiki, mutane suna da dalilin da za su yi gaba gaɗi cewa tsufa na fata na iya haifar da tsufa na duka jiki.
Tsufa fata na iya shafar kwakwalwa ta hanyar tsarin endocrine
Tsufa na fata na iya shafar dukkan jiki ta hanyar axis hypothalamic-pituitary-adrenal (HPA). Fatar ba kawai shamaki ba ne, har ila yau yana da ayyuka na neuroendocrine kuma yana iya amsawa ga yanayin muhalli da ɓoye hormones, neuropeptides da sauran abubuwa.
Alal misali, hasken ultraviolet zai iya haifar da ƙwayoyin fata don saki nau'o'in hormones da masu shiga tsakani, irin su cortisol da cytokines. Wadannan abubuwa zasu iya kunna tsarin HPA a cikin fata. Kunna axis na HPA yana haifar da hypothalamus don sakin hormone mai sakin corticotropin (CRH). Wannan kuma yana motsa glandan pituitary na baya don ɓoye hormone adrenocorticotropic (ACTH), wanda a ƙarshe ya sa glandan adrenal su ɓoye hormones na damuwa kamar cortisol. Cortisol na iya shafar yankuna da yawa na kwakwalwa, gami da hippocampus. Bayyanar cortisol na yau da kullun ko wuce kima na iya yin mummunan tasiri ga aikin neuronal da filastik a cikin hippocampus. Wannan kuma yana rinjayar aikin hippocampus da martanin damuwa na kwakwalwa.
Wannan sadarwar fata-zuwa-kwakwalwa ta tabbatar da cewa tsarin tsufa na iya haifar da yanayin muhalli, wanda ya fara haifar da halayen fata sannan kuma ya shafi kwakwalwa ta hanyar axis na HPA, yana haifar da matsalolin tsarin kamar raguwar fahimi da kuma haɗarin cututtukan zuciya.
Kwayoyin ji na fata suna ɓoye SASP kuma suna haifar da kumburi don fitar da tsufa da cututtukan da suka shafi shekaru
Tsufawar fata na iya shafar duka jiki ta hanyar haɓaka kumburi da rigakafi. Kwayoyin fata masu tsufa suna ɓoye wani abu mai suna "Senescence-associated secretory phenotype" (SASP), wanda ya haɗa da nau'ikan cytokines da matrix metalloproteinases. SASP yana da nau'ikan ilimin lissafi. Zai iya tsayayya da yanayin waje mai cutarwa a cikin sel na al'ada. Duk da haka, yayin da ayyukan jiki ke raguwa, babban ɓoye na SASP na iya haifar da kumburi a cikin jiki kuma ya haifar da rashin aiki na sel makwabta, ciki har da ƙwayoyin rigakafi da ƙwayoyin endothelial. Ana tsammanin wannan ƙananan ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta ce mai mahimmanci mai mahimmanci ga yawancin cututtuka masu alaka da shekaru.
Coenzymes suna shiga cikin metabolism na abubuwa masu mahimmanci kamar sukari, kitse, da furotin a cikin jikin ɗan adam, kuma suna taka muhimmiyar rawa wajen daidaita kayan jiki da kuzarin kuzari da kuma kiyaye ayyukan yau da kullun na physiological.NAD shine mafi mahimmancin coenzyme a cikin jikin mutum, wanda ake kira coenzyme I. Yana shiga cikin dubban redox enzymatic halayen a cikin jikin mutum. Abu ne da ba dole ba ne don haɓaka metabolism na kowane tantanin halitta. Yana da ayyuka da yawa, manyan ayyuka sune:
1. Inganta samar da makamashin halittu
NAD + yana haifar da ATP ta hanyar numfasawa ta salula, haɓaka makamashin tantanin halitta kai tsaye da haɓaka aikin salula;
2. Gyara kwayoyin halitta
NAD + shine kawai maɓalli don gyaran enzyme na DNA na PARP. Irin wannan nau'in enzyme yana shiga cikin gyaran DNA, yana taimakawa wajen gyara DNA da sel da suka lalace, yana rage yiwuwar maye gurbin kwayar halitta, kuma yana hana faruwar ciwon daji;
3. Kunna duk sunadaran tsawon rai
NAD + na iya kunna duk furotin na tsawon lokaci na 7, don haka NAD + yana da tasiri mafi mahimmanci akan rigakafin tsufa da tsawaita rayuwa;
4. Karfafa garkuwar jiki
NAD + yana ƙarfafa tsarin rigakafi kuma yana haɓaka rigakafi ta salon salula ta hanyar zaɓin rinjayar rayuwa da aikin ƙwayoyin T masu daidaitawa.
Musamman ma, tsufa yana tare da raguwar ci gaba a cikin nama da matakan NAD + na salula a cikin nau'ikan kwayoyin halitta iri-iri, gami da rodents da mutane. Ragewar matakan NAD + yana da alaƙa da alaƙa da yawancin cututtukan da ke da alaƙa da tsufa, gami da raguwar fahimi, ciwon daji, cututtukan rayuwa, sarcopenia, da rauni.
Babu wadatar NAD + mara iyaka a jikinmu. Abubuwan da ke ciki da aikin NAD + a cikin jikin mutum zai ragu tare da shekaru, kuma zai ragu da sauri bayan shekaru 30, yana haifar da tsufa na cell, apoptosis da asarar ikon sake farfadowa. .
Haka kuma, raguwar NAD + shima zai haifar da jerin matsalolin lafiya, don haka idan NAD + ba za a iya cika shi cikin lokaci ba, ana iya tunanin sakamakon.
Supplement daga abinci
Abinci irin su kabeji, broccoli, avocado, nama, namomin kaza, da edamame sun ƙunshi abubuwan da suka faru na NAD +, waɗanda za a iya canza su zuwa NAD * mai aiki a cikin jiki bayan sha.
Ƙuntata abinci da adadin kuzari
Matsakaicin ƙuntatawa na caloric na iya kunna hanyoyin jin kuzari a cikin sel kuma a kaikaice yana haɓaka matakan NAD *.
Ci gaba da motsi da motsa jiki
Matsakaicin motsa jiki na motsa jiki kamar gudu da yin iyo na iya haɓaka matakan NAD + na ciki, taimakawa haɓaka iskar oxygen a cikin jiki da haɓaka haɓakar kuzari.
Bi lafiyayyen halayen bacci
A lokacin barci, jikin mutum yana aiwatar da matakai masu mahimmanci na rayuwa da gyaran gyare-gyare, ciki har da haɗin NAD *. Samun isasshen barci yana taimakawa wajen kula da matakan NAD na yau da kullum.
05Karin NAD+ abubuwan farko
Mutanen da ke gaba ba za su iya samun magani ba
Mutanen da ke fama da ƙarancin aikin koda, masu fama da dialysis, masu ciwon farfaɗiya, mata masu juna biyu, mata masu shayarwa, yara, waɗanda ke fama da cutar kansa a halin yanzu, masu shan magani, da waɗanda ke da tarihin rashin lafiya, da fatan za a tuntuɓi likitan ku.
Tambaya: Menene ƙarin NAD + ake amfani dashi?
A: NAD + kari ne na abinci mai gina jiki wanda ke haɓaka coenzyme NAD + (nicotinamide adenine dinucleotide). NAD + yana taka muhimmiyar rawa a cikin metabolism na makamashi da gyaran sel a cikin sel.
Tambaya: Shin abubuwan NAD + suna aiki da gaske?
A: Wasu bincike sun nuna karin NAD + na iya taimakawa inganta haɓakar makamashin salula da rage saurin tsufa.
Tambaya: Menene tushen abincin NAD +?
A: Abubuwan abinci na NAD + sun haɗa da nama, kifi, kayan kiwo, wake, goro da kayan lambu. Waɗannan abincin sun ƙunshi ƙarin niacinamide da niacin, waɗanda za a iya canza su zuwa NAD + a cikin jiki.
Tambaya: Ta yaya zan zaɓi ƙarin NAD+?
A: Lokacin zabar abubuwan NAD +, ana ba da shawarar fara neman shawara daga likita ko masanin abinci mai gina jiki don fahimtar bukatun ku na sinadirai da matsayin lafiyar ku. Bugu da ƙari, zaɓi alama mai suna, bincika kayan aikin samfur da sashi, kuma bi jagorar sashi akan abin da aka saka samfurin.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Agusta-06-2024
