A yau, yayin da matsakaicin tsawon rayuwar mutane a duniya ke ƙaruwa sannu a hankali, rigakafin tsufa ya zama batu mai mahimmanci. Kwanan nan, Urolithin A, kalmar da ba a san shi ba a baya, ya shiga cikin jama'a a hankali. Wani abu ne na musamman wanda aka daidaita daga ƙwayoyin cuta na hanji kuma yana da alaƙa da lafiya. Wannan labarin zai bayyana asirin wannan abin al'ajabi na halitta - urolithin A.
Tarihinurolitin A (UA)Ana iya gano shi zuwa 2005. Yana da metabolite na ƙwayoyin cuta na hanji kuma ba za a iya ƙara shi kai tsaye ta hanyar hanyoyin abinci ba. Duk da haka, precursor ellagitannins suna da wadata a cikin 'ya'yan itatuwa daban-daban kamar rumman da strawberries.
Matsayin urolitin A
A ranar 25 ga Maris, 2016, wani babban bincike a cikin mujallar "Nature Medicine" ya ja hankalin masu sauraro game da dangantakarta da jinkirta tsufa. Tun lokacin da aka gano a cikin 2016 cewa UA na iya tsawaita tsawon rayuwar C. elegans yadda ya kamata, UA an yi amfani da shi a kowane matakan (sel hematopoietic, nama fata, kwakwalwa (gabobin), tsarin rigakafi, tsawon rayuwar mutum) kuma a cikin nau'ikan nau'ikan daban-daban. (C. elegans, melanogaster An nuna tasirin rigakafin tsufa a cikin ƙudaje na 'ya'yan itace, mice, da mutane.
(1) Anti-tsufa da haɓaka aikin tsoka
Wani gwajin gwaji na asibiti da aka buga a cikin JAMA Network Open, wata jarida mai mahimmanci na Journal of the American Medical Association, ya nuna cewa ga tsofaffi ko mutanen da ke da wahalar motsi saboda rashin lafiya, abubuwan UA na iya taimakawa wajen inganta lafiyar tsoka da kuma yin motsa jiki da ake bukata.
(2) Taimakawa wajen haɓaka ikon rigakafin ƙwayar cuta na immunotherapy
A cikin 2022, ƙungiyar bincike na Florian R. Greten daga Cibiyar Georg-Speyer-Haus na Tumor Biology and Experimental Therapeutics a Jamus sun gano cewa UA na iya haifar da mitophagy a cikin ƙwayoyin T, inganta sakin PGAM5, kunna hanyar siginar Wnt, kuma inganta T memory stem sel. samuwar, ta haka inganta anti-tumor rigakafi.
(3) Maimaita tsufa na ƙwayoyin cuta na hematopoietic da tsarin rigakafi
A cikin wani bincike na 2023, Jami'ar Lausanne a Switzerland ta yi nazarin tasirinsa akan tsarin hematopoietic ta hanyar barin berayen 'yan watanni 18 su ci abinci mai arzikin urolithin A na tsawon watanni 4 tare da lura da canje-canje a cikin ƙwayoyin jininsu kowane wata. Tasiri.
Sakamakon ya nuna cewa rage cin abinci na UA ya karu da adadin kwayoyin halitta na hematopoietic da lymphoid progenitor sel, kuma ya rage yawan adadin erythroid progenitor sel. Wannan binciken ya nuna cewa wannan abincin na iya canza wasu canje-canje a cikin tsarin hematopoietic da ke hade da tsufa.
(4) Tasirin hana kumburi
Ayyukan anti-mai kumburi na UA ya fi ƙarfi kuma yana iya hana nau'ikan abubuwan kumburi na yau da kullun kamar TNF-α. Daidai saboda wannan dalili ne UA ke taka rawa a cikin jiyya daban-daban na kumburi ciki har da kwakwalwa, mai, zuciya, hanji da kyallen hanta. Yana iya sauƙaƙa kumburi a cikin kyallen takarda daban-daban.
(5) Kariyar Neuro
Wasu malaman sun tabbatar da cewa UA na iya hana hanyar apoptosis da ke da alaka da mitochondria kuma ta tsara hanyar siginar p-38 MAPK, ta haka ne ya hana apoptosis mai haifar da damuwa. Alal misali, UA na iya inganta ƙimar rayuwa na ƙananan ƙwayoyin cuta waɗanda ke motsa su ta hanyar damuwa na oxidative kuma yana da kyakkyawan aikin neuroprotective.
(6)Tasirin mai
UA na iya shafar ƙwayar lipid metabolism da lipogenesis. Nazarin ya nuna cewa UA na iya haifar da kunna kitse mai launin ruwan kasa da launin ruwan fari mai launin ruwan kasa, yayin da yake hana tarin kitse da abinci ke haifarwa.
(7) Inganta kiba
UA kuma na iya rage tarin kitse a cikin adipocytes da ƙwayoyin hanta da aka yi amfani da su a cikin vitro kuma suna ƙara yawan iskar shaka. Yana iya canza ƙarancin T4 a cikin thyroxine zuwa mafi yawan aiki T3, haɓaka ƙimar rayuwa da samar da zafi ta hanyar siginar thyroxine. , don haka taka rawa wajen magance kiba.
(8) Kare idanu
Mitophagy inducer UA na iya rage yawan damuwa a cikin retina mai tsufa; yana rage matakin cytosolic cGAS kuma yana rage kunna glial cell a cikin tsofaffin retina.
(9) Kula da fata
Daga cikin duk abubuwan da aka samu na ƙwayar hanji na mammalian, UA yana da aikin antioxidant mafi ƙarfi, na biyu kawai zuwa proanthocyanidin oligomers, catechins, epicatechin da 3,4-dihydroxyphenylacetic acid. jira.
Urolithin A yanayin aikace-aikace
A cikin 2018, Hukumar Abinci da Magunguna ta Amurka ta ayyana UA a matsayin wani abu mai cin abinci "wanda aka san shi da aminci" kuma ana iya ƙara shi cikin girgizar furotin, abubuwan maye gurbin abinci, oatmeal nan take, sandunan furotin mai gina jiki da abubuwan sha na madara (har zuwa 500 MG). / hidima)), yogurt Girkanci, yogurt mai gina jiki mai gina jiki da furotin madara (har zuwa 1000 mg / hidima).
Hakanan za'a iya ƙara UA zuwa samfuran kula da fata, gami da creams na rana, kirim ɗin dare da haɗin jini, wanda aka ƙera don haɓaka hydration na fata da mahimmancin rage wrinkles, haɓaka nau'in fata daga ciki, da yaƙi da alamun tsufa. , Taimakawa fata zama matashi.
Urolitin A tsarin samarwa
(1) Tsarin fermentation
An fara samun samar da kasuwancin UA ta hanyar fasaha na fermentation, wanda akasari ana yin shi ne daga bawon rumman kuma yana da abun ciki na urolithin A fiye da 10%.
(2) Tsarin haɗakar sinadarai
Tare da ci gaba da haɓakawa da ci gaba da bincike, haɓakar sinadarai shine muhimmiyar hanyar samar da masana'antu na urolithin A. Suzhou Myland Pharm shine ƙarin ƙarin ilimin kimiyyar rayuwa, ƙirar al'ada da kamfanin sabis na masana'antu wanda zai iya samar da High-tsarki, babban girma urolithin A. foda albarkatun kasa.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Agusta-23-2024
