A yau, yayin da matsakaicin tsawon rayuwar mutane a duniya ke ƙaruwa a hankali, maganin tsufa ya zama muhimmin batu. Kwanan nan, Urolithin A, kalmar da ba a san ta sosai ba a baya, ta fara bayyana a bainar jama'a a hankali. Wani abu ne na musamman da aka samar daga ƙwayoyin cuta na hanji kuma yana da alaƙa da lafiya. Wannan labarin zai bayyana sirrin wannan abu na halitta mai ban mamaki - urolithin A.
Tarihinurolithin A (UA)za a iya gano shi tun daga shekarar 2005. Yana da sinadaran ƙwayoyin cuta na hanji kuma ba za a iya ƙara shi kai tsaye ta hanyar abinci ba. Duk da haka, sinadarin ellagitannins da ya riga ya fara yana da wadataccen 'ya'yan itatuwa daban-daban kamar rumman da strawberries.
Matsayin urolithin A
A ranar 25 ga Maris, 2016, wani babban bincike a mujallar "Nature Medicine" ya jawo hankalin masu sauraro ga alaƙar da ke tsakaninta da jinkirta tsufan ɗan adam. Tun lokacin da aka gano a shekarar 2016 cewa UA na iya tsawaita tsawon rayuwar C. elegans yadda ya kamata, an yi amfani da UA a dukkan matakai (ƙwayoyin halittar jini, nama na fata, kwakwalwa (gabobi), tsarin garkuwar jiki, tsawon rayuwar mutum) da kuma a nau'ikan halittu daban-daban (C. elegans, melanogaster. An nuna tasirin hana tsufa sosai a cikin kwari, beraye, da mutane.
(1) Hana tsufa da kuma inganta aikin tsoka
Wani gwaji na asibiti da aka buga a JAMA Network Open, wani mujallar reshe ta Journal of the American Medical Association, ya nuna cewa ga tsofaffi ko mutanen da ke da wahalar motsawa saboda rashin lafiya, ƙarin abinci na UA na iya taimakawa wajen inganta lafiyar tsoka da kuma yin motsa jiki da ake buƙata.
(2) Taimaka wajen inganta ƙarfin maganin ciwon daji na immunotherapy
A shekarar 2022, ƙungiyar bincike ta Florian R. Greten daga Cibiyar Georg-Speyer-Haus ta Biology da Experimental Therapeutics a Jamus ta gano cewa UA na iya haifar da mitophagy a cikin ƙwayoyin T, yana haɓaka sakin PGAM5, yana kunna hanyar siginar Wnt, da kuma haɓaka samuwar ƙwayoyin T na ƙwaƙwalwar ajiya, ta haka yana haɓaka garkuwar rigakafi ta hana ƙari.
(3) Juya tsufar ƙwayoyin halittar jini da tsarin garkuwar jiki
A wani bincike da aka gudanar a shekarar 2023, Jami'ar Lausanne da ke Switzerland ta yi nazari kan tasirinsa kan tsarin jinin jini ta hanyar barin berayen watanni 18 su ci abinci mai wadataccen urolithin A na tsawon watanni 4 da kuma lura da canje-canje a cikin ƙwayoyin jininsu kowane wata. Tasiri.
Sakamakon ya nuna cewa abincin UA ya ƙara yawan ƙwayoyin halittar jini da ƙwayoyin halittar lymphoid, sannan ya rage adadin ƙwayoyin halittar erythroid progenitor. Wannan binciken ya nuna cewa wannan abincin na iya sauya wasu canje-canje a cikin tsarin jinin da ke da alaƙa da tsufa.
(4) Tasirin hana kumburi
Ayyukan hana kumburi na UA sun fi ƙarfi kuma suna iya hana nau'ikan abubuwan kumburi iri-iri kamar TNF-α. Wannan dalili ne ya sa UA ke taka rawa a cikin magunguna daban-daban na kumburi, ciki har da kwakwalwa, kitse, zuciya, hanji da kyallen hanta. Yana iya rage kumburi a cikin kyallen takarda daban-daban.
(5) Kariyar Jijiyoyi
Wasu masana sun tabbatar da cewa UA na iya hana hanyar apoptosis da ke da alaƙa da mitochondria da kuma daidaita hanyar siginar p-38 MAPK, ta haka yana hana apoptosis da damuwa ta oxidative ke haifarwa. Misali, UA na iya inganta ƙimar rayuwa na ƙwayoyin jijiyoyi da damuwa ta oxidative ke motsa su kuma yana da kyakkyawan aikin kariya daga jijiyoyi.
(6) Tasirin kitse
UA na iya shafar metabolism na lipids na ƙwayoyin halitta da kuma lipogenesis. Bincike ya nuna cewa UA na iya haifar da kunna kitsen launin ruwan kasa da launin ruwan kasa na farin kitse, yayin da yake hana taruwar kitse da abinci ke haifarwa.
(7) Inganta kiba
UA kuma na iya rage tarin kitse a cikin ƙwayoyin adipocytes da ƙwayoyin hanta da aka haɓaka a cikin vitro da kuma ƙara yawan iskar shaka na kitse. Yana iya canza T4 mara aiki a cikin thyroxine zuwa T3 mai aiki, yana haɓaka yawan metabolism da samar da zafi ta hanyar siginar thyroxine., don haka yana taka rawa wajen sarrafa kiba.
(8) Kare idanu
Mai haifar da mitophagy UA zai iya rage damuwa ta oxidative a cikin retina mai tsufa; yana rage matakin cytosolic cGAS kuma yana rage kunna ƙwayoyin glial a cikin retina mai tsufa.
(9) Kula da fata
Daga cikin dukkan sinadaran da aka samu a cikin hanjin dabbobi masu shayarwa, UA tana da mafi ƙarfin aikin hana tsufa, na biyu kawai bayan proanthocyanidin oligomers, catechins, epicatechin da 3,4-dihydroxyphenylacetic acid. jira.
Yanayin amfani da Urolithin A
A shekarar 2018, Hukumar Abinci da Magunguna ta Amurka ta ayyana UA a matsayin wani abu da ake ci "wanda aka amince da shi a matsayin mai lafiya" kuma ana iya ƙara shi a cikin shakes na furotin, abubuwan sha na maye gurbin abinci, oatmeal nan take, sandunan furotin masu gina jiki da abubuwan sha na madara (har zuwa 500 mg/sauƙi)), yogurt na Girka, yogurt mai yawan furotin da shakes na furotin na madara (har zuwa 1000 mg/sauƙi).
Ana iya ƙara UA a cikin kayayyakin kula da fata, gami da man shafawa na rana, man shafawa na dare da haɗin serum, waɗanda aka tsara don haɓaka ruwan fata da rage wrinkles sosai, inganta yanayin fata daga ciki zuwa waje, da kuma yaƙi da alamun tsufa yadda ya kamata.
Tsarin samar da Urolithin A
(1) Tsarin fermentation
Ana fara samun nasarar samar da UA ta hanyar kasuwanci ta hanyar fasahar fermentation, wadda galibi ana yin ta ne daga bawon rumman kuma tana da sinadarin urolithin A fiye da kashi 10%.
(2) Tsarin hada sinadarai
Tare da ci gaba da kirkire-kirkire da haɓaka bincike, haɗakar sinadarai muhimmin hanya ce ta samar da urolithin A a masana'antu. Suzhou Myland Pharm kamfani ne mai haɓaka kimiyya ta rayuwa, haɗakarwa ta musamman da ayyukan masana'antu wanda zai iya samar da kayan urolithin A mai tsabta, mai girma.
Bayanin Kariya: Wannan labarin don bayanai ne kawai kuma bai kamata a fassara shi a matsayin wata shawara ta likita ba. Wasu daga cikin bayanan da aka wallafa a shafin yanar gizo sun fito ne daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin tsarawa, tsarawa da kuma gyara labarai kawai. Manufar isar da ƙarin bayani ba yana nufin cewa kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abubuwan da ke ciki ba. Kullum ku tuntuɓi ƙwararren likita kafin amfani da duk wani kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin Saƙo: Agusta-23-2024
