Salidroside: Bayyana sirrin abubuwan antioxidant na Rhodiola rosea

Salidroside wani antioxidant ne na halitta wanda ke kare ƙwayoyin jijiya ta hanyar lalata ROS da hana apoptosis cell.

Yawan nauyin calcium na cikin salula yana daya daga cikin manyan abubuwan da ke haifar da apoptosis na neuronal. Rhodiola rosea tsantsa da salidroside iya rage karuwa a cikin cell free matakan calcium jawo ta oxidative danniya da kuma kare mutum cortical Kwayoyin daga glutamate. Salidroside zai iya hana lipopolysaccharide-induced microglial kunnawa, hana NO samarwa, hana inducible nitric oxide synthase (iNOS), da kuma rage TNF-α da IL-1β, IL-6 matakan.

Salidroside ya hana NADPH oxidase 2 / ROS / mitogen-activated protein kinase (MAPK) da mai kula da amsawa na ci gaba da lalata DNA 1 (REDD1) / mammalian mammalian rapamycin (mTOR) / p70 ribosome S6 kinase siginar sigina yana kunna hanyar AMP-dogara. protein kinase/mai sarrafa bayanan shiru 1, RAS memba na dangin dangi A/MAPK da PI3K/Akt hanyoyin sigina.

1. Salidroside yana adawa da lalacewar free radical kuma yana kare jiki

Jiki na iya samar da wani takamaiman adadin free radicals na endogenous free radicals a lokacin al'ada tafiyar matakai na jiki, da kuma wani physiological kashi na free radicals wajibi ne don kula da jiki na al'ada ayyukan physiological. Haka kuma akwai tsarin ɓarkewar ɓacin rai a cikin jiki don cire radicals kyauta waɗanda suka wuce allurai na physiological don kada su cutar da lafiyar jiki.

Duk da haka, a ƙarƙashin rinjayar wasu dalilai na musamman na muhalli, radicals masu kyauta na jiki na jiki zai wuce kima kuma ya zarce adadin radicals na tsarin, yana haifar da rashin daidaituwa a cikin tsarin samar da iskar oxygen kyauta, wanda zai haifar da tarawar oxygen free radicals. a cikin jiki, ta haka yana haifar da lalacewa tantanin halitta. lalacewa.

Bincike ya nuna cewa yanayin hypoxic a ƙarƙashin yanayi na plateau zai iya haifar da rashin daidaituwa a cikin metabolism na oxygen-free radicals, tarawa free radicals intracellular da kuma ƙara lipid peroxidation kayayyakin. Nazarin ya nuna cewa salidroside na iya kare ƙwayoyin nama ta hanyar zubar da radicals kyauta a cikin jiki.

2. Salidroside antagonizes hypoxia don kiyaye zaman lafiyar aikin mitochondrial

Kimanin kashi 80-90% na iskar oxygen na ciki ana amfani dashi don iskar oxygen a cikin mitochondria don samar da ATP da samar da nau'in oxygen mai amsawa ROS don kula da ayyukan rayuwa na al'ada. Kawai 10-20% na oxygen yana da kyauta a waje da mitochondria don biosynthesis, lalata, biotransformation (detoxification), da dai sauransu. Mitochondrial na numfashi aiki yana inganta a cikin m hypoxia ko a farkon mataki na hypoxia, wanda aka bayyana a matsayin ramuwa mayar da martani. tsarin numfashi na jiki.

Mummunan hypoxia zai fara rinjayar iskar oxygenation na mitochondria da kuma rashin aikin aikin rayuwa na jiki, rage samar da ƙwayoyin cuta, da raunana karfin biotransformation, ta haka yana rinjayar ayyukan kyallen takarda da gabobin. Nazarin ya nuna cewa salidroside na iya kare kiyaye aikin mitochondrial ta hanyar rage abun ciki na ROS a cikin mitochondria tantanin halitta, ƙara yawan aikin SOD, da ƙara yawan mitochondria.

3. Myocardial m sakamako na salidroside

Nazarin ya nuna cewa tsarin zuciya da jijiyoyin jini shine babban tsarin da ke canza yanayin hypoxic. Yanayin hypoxic zai haifar da raunin jiki na aerobic metabolism don raunana da rashin wadataccen makamashi, yana haifar da bayyanar cututtuka irin su hypoxia, ischemia, da apoptosis na sel myocardial. Nazarin ya nuna cewa salidroside na iya haɓaka aikin zuciya da haɓaka microcirculation ta hanyar dilating arterial and venues jijiyoyi, inganta bugun jini na zuciya, canza hemodynamics na zuciya, rage nauyin zuciya, da rage lalacewar ischemic na myocardial.
A takaice dai, salidroside na iya yin aiki akan tsarin zuciya da jijiyoyin jini ta hanyoyi da yawa, hanyoyi, da maƙasudi, yana kare apoptosis na sel na miyocardial wanda ke haifar da dalilai da yawa, da haɓaka ischemia na jiki da yanayin hypoxia. A cikin yanayi mai banƙyama, tsoma bakin Rhodiola rosea yana da matukar mahimmanci wajen kare kyallen jikin jiki da gabobin jiki da kiyaye kwanciyar hankali na ayyukan tantanin halitta. Yana taka muhimmiyar rawa wajen hanawa da kuma rage cututtuka na tsayi.
Halin halin yanzu na samar da salidroside

1)Yafi dogara akan hakar shuka

Rhodiola rosea shine albarkatun kasa nasalidroside.Rhodiola rosea a matsayin nau'in tsire-tsire na herbaceous na shekara-shekara, galibi yana tsiro a cikin wuraren da ke da tsananin sanyi, anoxia, bushewa, da babban bambancin zafin jiki tsakanin dare da rana a tsayin mita 1600-4000. Yana daya daga cikin tsiron dajin daji. Kasar Sin tana daya daga cikin manyan wuraren samar da Rhodiola rosea a duniya, amma dabi'ar rayuwar Rhodiola rosea na musamman ne. Ba wai kawai yana da wahala a noma ta hanyar wucin gadi ba, amma yawan amfanin gonar daji yana da ƙasa sosai. Ratar bukatar Rhodiola rosea na shekara-shekara ya kai tan 2,200.

2) Haɗin sinadarai da fermentation na halitta

Saboda ƙarancin abun ciki da tsadar samarwa a cikin tsire-tsire, baya ga hanyoyin hakar yanayi, hanyoyin samar da salidroside kuma sun haɗa da hanyoyin haɗin sinadarai, hanyoyin haɓakar ƙwayoyin halitta, da sauransu. hanyar fasaha don haɓaka bincike da samar da salidroside. A halin yanzu, Suzhou Mailun ya sami sakamako na bincike da ci gaba kuma ya sami ci gaban masana'antu.