Salidroside: Gano sirrin kaddarorin antioxidant na Rhodiola rosea

Salidroside wani maganin hana tsufa ne na halitta wanda ke kare ƙwayoyin jijiyoyi ta hanyar kawar da ROS da kuma hana ƙwayoyin cuta.

Yawan sinadarin calcium a cikin ƙwayoyin halitta yana ɗaya daga cikin manyan abubuwan da ke haifar da apoptosis na jijiyoyi. Ruwan Rhodiola rosea da saldroside na iya rage ƙaruwar matakan calcium marasa ƙwayoyin halitta da ke cikin ƙwayoyin halitta wanda damuwa ta oxidative ke haifarwa da kuma kare ƙwayoyin cortical na ɗan adam daga glutamate. Salidroside na iya hana kunna microglial da lipopolysaccharide ke haifarwa, hana samar da NO, hana ayyukan nitric oxide synthase (iNOS) da ba a iya jurewa ba, da kuma rage matakan TNF-α da IL-1β, IL-6.

Salidroside yana hana NADPH oxidase 2/ROS/mitogen-activated protein kinase (MAPK) da kuma mai kula da martanin ci gaba da lalacewar DNA 1 (REDD1)/manufar rapamycin (mTOR)/p70 ribosome na dabbobi masu shayarwa Hanyar siginar furotin S6 kinase tana kunna tsarin siginar furotin kinase/mai kula da bayanai na shiru 1, tsarin siginar RAS mai kama da juna A/MAPK da hanyoyin siginar PI3K/Akt.

1. Salidroside yana hana lalacewar ƙwayoyin cuta masu rai kuma yana kare jiki.

Jiki na iya samar da wani adadin ƙwayoyin cuta masu rai a cikin jiki yayin ayyukan jiki na yau da kullun, kuma akwai wani adadin ƙwayoyin cuta masu rai a cikin jiki don kiyaye ayyukan jiki na yau da kullun. Akwai kuma tsarin cire ƙwayoyin cuta masu rai a cikin jiki don cire ƙwayoyin cuta masu rai waɗanda suka wuce adadin ƙwayoyin cuta don kada su cutar da lafiyar jiki.

Duk da haka, ƙarƙashin tasirin wasu dalilai na musamman na muhalli, ƙwayoyin cuta na ciki na jiki za su yi yawa kuma su wuce ƙimar cire ƙwayoyin cuta na tsarin, wanda ke haifar da rashin daidaito a cikin tsarin samar da ƙwayoyin cuta na oxygen kyauta a cikin jiki, wanda ke haifar da tarin ƙwayoyin cuta na oxygen kyauta a cikin jiki, wanda hakan ke haifar da lalacewar membrane na ƙwayoyin halitta.

Bincike ya nuna cewa yanayin hypoxic a ƙarƙashin yanayin da ke sama na iya haifar da rashin daidaito a cikin metabolism na radical-free metabolism, yana tara free radicals a cikin ƙwayoyin halitta da kuma ƙara yawan lipid peroxidation. Nazarin ya nuna cewa saldroside na iya kare ƙwayoyin nama ta hanyar kawar da free radicals a cikin jiki.

2. Salidroside yana hana hypoxia don kiyaye daidaiton aikin mitochondrial

Ana amfani da kusan kashi 80-90% na iskar oxygen ta cikin ƙwayoyin halitta don samar da iskar oxygen ta halitta a cikin mitochondria don samar da ATP da kuma samar da nau'in iskar oxygen mai amsawa ROS don kiyaye ayyukan rayuwa na yau da kullun na ƙwayoyin halitta. Kashi 10-20% na iskar oxygen ne kawai ke da 'yanci a wajen mitochondria don biosynthesis, lalacewa, biotransformation (detoxification), da sauransu. Aikin numfashi na Mitochondrial yana ƙaruwa a cikin ɗan ƙaramin hypoxia ko a farkon matakin hypoxia, wanda ke bayyana a matsayin martanin diyya na tsarin numfashi na jiki.

Babban rashin isasshen iskar oxygen zai fara shafar iskar oxygen da ke fitowa daga mitochondria da kuma matsalolin aikin metabolism na jiki, rage samar da neurotransmitters, da kuma raunana ikon biotransformation, wanda hakan zai shafi ayyukan kyallen takarda da gabobin jiki. Bincike ya nuna cewa saldroside na iya kare aikin mitochondria ta hanyar rage yawan ROS a cikin mitochondria ta sel, ƙara yawan SOD, da kuma ƙara yawan mitochondria.

3. Tasirin kariya daga zuciya ta hanyar sinadarin salidroside

Bincike ya nuna cewa tsarin zuciya da jijiyoyin jini shine babban tsarin da ke canza yanayin hypoxic. Yanayin hypoxic zai sa metabolism na aerobic na jiki ya raunana kuma ya kasa samar da kuzari, wanda hakan ke haifar da alamu kamar hypoxia, ischemia, da apoptosis na ƙwayoyin zuciya. Bincike ya nuna cewa saldroside na iya haɓaka aikin zuciya da inganta microcirculation ta hanyar faɗaɗa jijiyoyin jini da jijiyoyin jini, inganta zubar jini a cikin zuciya, canza yanayin hemodynamics na zuciya, rage nauyin zuciya, da rage lalacewar ischemic na zuciya.
A takaice dai, saldroside na iya aiki a kan tsarin zuciya da jijiyoyin jini ta hanyoyi daban-daban, hanyoyi, da kuma manufofi, yana kare apoptosis na ƙwayoyin zuciya da jijiyoyin jini da ke haifar da dalilai da yawa, da kuma inganta yanayin ischemia da hypoxia na jiki. A cikin yanayin hypoxic, shiga tsakani na Rhodiola rosea yana da matuƙar muhimmanci wajen kare kyallen jiki da gabobin jiki da kuma kiyaye daidaiton ayyukan ƙwayoyin halitta. Yana taka muhimmiyar rawa wajen hana da rage radadin cutar tsayi.
Matsayin da ake ciki a yanzu game da samar da sinadarin salidroside

1) Ya fi dogara ga cire tsire-tsire

Rhodiola rosea shine asalin shukar da aka samo asali dagasalidroside.A matsayin wani nau'in shukar ciyawa mai dawwama, Rhodiola rosea galibi tana girma ne a yankunan da ke da sanyi mai yawa, rashin isasshen ruwa, bushewa, da kuma babban bambancin zafin rana da dare a tsayin mita 1600-4000. Ita ce ɗaya daga cikin tsire-tsire masu tsayin daji. China tana ɗaya daga cikin manyan wuraren samar da Rhodiola rosea a duniya, amma halayen rayuwar Rhodiola rosea na musamman ne. Ba wai kawai yana da wahala a noma ta hanyar wucin gadi ba, har ma da yawan amfanin gona na nau'ikan daji yana da ƙasa sosai. Gibin buƙata na shekara-shekara ga Rhodiola rosea yana da girman tan 2,200.

2) Haɗakar sinadarai da kuma fermentation na halitta

Saboda ƙarancin abun ciki da kuma tsadar samar da shi a cikin shuke-shuke, ban da hanyoyin fitar da sinadarai na halitta, hanyoyin samar da salidroside sun haɗa da hanyoyin haɗa sinadarai, hanyoyin fermentation na halittu, da sauransu. Daga cikinsu, yayin da fasahar ke ci gaba da girma, fermentation na halittu ya zama babbar hanyar fasaha don haɓaka bincike da samar da salidroside. A halin yanzu, Suzhou Mailun ta cimma sakamakon bincike da haɓakawa kuma ta cimma nasarar masana'antu.