Mitochondria na da matukar muhimmanci a matsayin makamashin kwayoyin jikin mu, yana samar da makamashi mai yawa don ci gaba da bugun zuciyarmu, numfashin huhunmu da kuma aikin jikinmu ta hanyar sabuntawa yau da kullum.Duk da haka, bayan lokaci, kuma tare da shekaru, tsarin samar da makamashi, mitochondria, ya zama mai saukin kamuwa da lalacewa kuma ya rasa ikon yin aiki yadda ya kamata.Mitochondria mai cikakken aiki yana da mahimmanci ga rayuwar mutum.Koyaya, mitochondria shima yana da saurin kamuwa da lalacewa daga tushe iri-iri, gami da damuwa na oxidative, kumburi, da gubobi na muhalli.Wadannan abubuwan zasu iya haifar da lalacewa ga DNA na mitochondrial, suna lalata ikon su na samar da ATP da sauran mahadi masu mahimmanci.
Abin farin ciki, jikinmu yana zaɓar mitochondria mai lalacewa da rashin aiki daga sel ta hanyar mitochondrial autophagy don kula da lafiya mafi kyau da kuma guje wa wasu mummunan tasiri na waɗannan mitochondria da suka lalace, bisa ga binciken da ya nuna cewa tsarin mitochondrial autophagy yana da tasiri a cikin maganin rigakafi. tsufa.Mu fahimci alakar dake tsakanin mitochondria da anti-tsufa!
Menene matsayin mitochondria?
Mitochondria sune mahimman kwayoyin halitta waɗanda ke samar da makamashi a cikin ƙwayoyin mu.Babban aikin su shine samar da adenosine triphosphate (ATP), wanda shine kudin makamashi na sel.Yawan mitochondria da muke da shi, yawan ATP da za mu iya samarwa, wanda ke haifar da ƙara yawan makamashi da rage gajiya.Daga cikin manyan rawar da take takawa akwai:
(1)samar da makamashi da kuma matsakaici na rayuwa zuwa jiki
(2)Mitochondrial autophagy yana gane mitochondria da ya lalace kuma ya zaɓi ya cire su, kuma kawar da waɗannan lalacewar mitochondria yana inganta biosynthesis na sabon mitochondria.
(3)Zai iya taka rawa wajen hana mutuwar kwayar halitta ta hanyar cire mitochondria
(4)An danganta shi da haɓakar matsalolin kiwon lafiya da yawa, ciki har da cututtukan zuciya, cututtukan neurodegenerative da ma wasu nau'ikan ciwon daji.
Menene alaƙa tsakanin mitochondria da anti-tsufa?
Nazarin ya nuna cewa yayin da muke tsufa, izini ta hanyar mitochondrial autophagy yana dysregulated, wanda ke nufin cewa ƙwayoyin mitochondrial ba su da ikon share ayyukansu.Ba tare da ingantattun hanyoyin sarrafa inganci kamar mitochondrial autophagy ba, ana iya ƙara lalacewa ta salula.
A cikin binciken dabba, an ga tsawon rayuwa lokacin da aka bayyana kwayoyin halittar da ke daidaita autophagy na mitochondrial, suna nuna cewa an haɗa su da mitochondrial autophagy da tsawon rai.Bugu da ƙari, ana iya ganin rashin lafiyar mitochondrial autophagy a yawancin cututtuka da suka shafi shekaru, ciki har da Parkinson's da Alzheimer's disease, cututtukan zuciya, da kuma ciwon daji, yana nuna cewa ayyukan da aka yi amfani da su na mitochondrial autophagy na iya samun tasiri a rigakafin cututtuka da magani.A ƙarshe, mabuɗin tsufa cikin alheri ya ta'allaka ne cikin fahimta da goyan bayan matakai masu sarƙaƙƙiya waɗanda ke sa jiki aiki.Ta yin aiki don inganta lafiyar mitochondrial autophagy da kuma yin zaɓin salon rayuwa waɗanda ke ba da fifiko ga jin daɗinmu, za mu iya buɗe asirin ga rayuwa mai tsawo da lafiya!
Yadda ake ƙara mitochondrial autophagy
(1)Yi la'akari da ƙayyadaddun azumi da ƙuntataccen kalori
Nazarin ya nuna cewa mitochondrial autophagy na iya motsa jiki ta hanyoyi daban-daban na rayuwa.Alal misali, an nuna motsa jiki don ƙara yawan autophagy na mitochondrial, don haka inganta aikin mitochondrial.Bugu da ƙari, abubuwan da ake amfani da su na abinci kamar azumi na tsaka-tsaki ko ƙuntatawa na kalori kuma na iya tayar da mitochondrial autophagy, wanda ya haifar da karuwar mitochondria mai lafiya.
(2)Motsa jiki na yau da kullun
Motsa jiki shine mafi sauƙi kuma mafi sauƙi don riko da shi.Yana iya inganta kiwon lafiya da kuma tsawon rai da kuma inganta aikin mitochondrial da kuma haifar da mitochondrial autophagy, don haka motsa jiki za a iya tsara yadda ya kamata tare da wasu ƙarfin, aerobic da kuma horar da juriya don kara yawan mitochondrial autophagy.
(3)Urolithin A kwayoyin halitta ne da ke haifar da autophagy na mitochondrial
Urolithin A wani fili ne na metabolite da aka samar ta hanyar juyar da tannins ellagic ta kwayoyin hanji.Abubuwan da ke gaba da shi sune ellagic acid da ellagitannin, waɗanda za a iya samun su a cikin tsire-tsire masu yawa, kamar rumman, strawberries, raspberries, gyada, da sauransu, amma ba wai yana cikin abinci ba, saboda wasu ƙwayoyin cuta ne kawai ke iya canza ellagitannin zuwa urolithin.Kuma urolithin A, wani sinadari na halitta da aka samu daga abubuwan da ake ci, shine sinadarin da aka nuna yana haifar da autophagy na mitochondrial.
Muhimmancin mitochondrial autophagy
Mitochondrial autophagy tsari ne na halitta kuma mai mahimmanci wanda ke taimakawa kula da mitochondria lafiya a cikin sel mu.Wannan tsari ya haɗa da gano mitochondria mai lalacewa ko maras aiki da zaɓin cire su daga tantanin halitta don samar da sababbin mitochondria mai yiwuwa don maye gurbin su.A lokaci guda kuma, tsarin mitochondrial autophagy yana taimakawa wajen tabbatar da cewa matakan makamashin jikinmu ya kasance da ƙarfi kuma ƙwayoyinmu da kyallen jikinmu sun kasance lafiya da aiki.
A ƙarshe, kiyaye lafiyar mitochondria yana da mahimmanci ga lafiyarmu da jin daɗin rayuwarmu gaba ɗaya, kuma ƙwayoyinmu sun samo asali wani tsari da ake kira mitochondrial autophagy don tabbatar da cewa muna ci gaba da samar da mitochondria lafiya.Duk da haka, abubuwan da suka shafi salon rayuwa (irin su motsa jiki) da kuma abubuwan da suka shafi abinci (irin su cin abinci na ketogenic) da kuma yin amfani da kayan aiki na iya tallafawa aikin mitochondrial kuma yana taimakawa wajen hana cututtuka masu shekaru.Ta hanyar kula da mitochondria, za mu iya tabbatar da cewa muna da kuzari da kuzarin da muke bukata don rayuwa cikakke.
Bugu da kari, za mu iya a fili san mahada tsakanin mitochondria da anti-tsufa, yayin da muka tsufa, da mitochondrial autophagy tsari ya lalace, wato, shi take kaiwa zuwa ga tara mitochondria a cikin sel, wanda azumi, kalori ƙuntatawa, urolithin A. , da dai sauransu na iya haifar da mitochondrial autophagy kuma zai iya inganta kiwon lafiya da kuma tsufa, inda duka NAD + da urolithin A suna taimakawa wajen samar da sabon mitochondria ta hanyar tsarin da ake kira tsarin biogenesis da ake kira biogenesis;duk da haka, urolithin A yana da wani muhimmin aiki.Yana inganta tsarin da ake kira mitochondrial autophagy, wanda ake cire mitochondria da suka lalace kuma a sake yin amfani da su zuwa sababbin mitochondria mafi inganci.Mutane da yawa a cikin rayuwarmu ƙila ba za su iya ci gaba da motsa jiki na dogon lokaci ba, amma siffar samfurin da muke bayarwa, Urolithin A, na iya samar da ingantacciyar lafiya.
Tambaya: Shin akwai takamaiman abinci a rayuwar ku waɗanda zasu taimaka hana tsufa?
A: Haka ne, wasu abinci masu arziki a cikin antioxidants, bitamin da ma'adanai na iya taimakawa wajen inganta fata mai kyau da kuma rage tsarin tsufa.Misalai sun haɗa da 'ya'yan itatuwa, kayan lambu, sunadaran sunadaran da ba su da lafiya.
Lokacin aikawa: Juni-01-2023
