Me kuke buƙatar sani game da nicotinamide adenine dinucleotide (NAD+)?

NAD+ kuma ana kiransa coenzyme, kuma cikakken sunansa nicotinamide adenine dinucleotide. Yana da mahimmancin coenzyme a cikin zagayowar tricarboxylic acid. Yana haɓaka metabolism na sukari, mai, da amino acid, yana shiga cikin haɓakar kuzari, kuma yana shiga cikin dubban halayen kowane tantanin halitta. Yawancin bayanan gwaji sun nuna cewa NAD + yana da hannu sosai a cikin nau'o'in ayyukan ilimin lissafi na asali a cikin kwayoyin halitta, ta haka ne ke shiga cikin mahimman ayyukan salula irin su makamashin makamashi, gyaran DNA, gyare-gyaren kwayoyin halitta, kumburi, rhythms na halitta, da kuma juriya na damuwa.

Dangane da binciken da ya dace, matakin NAD + a cikin jikin mutum zai ragu da shekaru. Rage matakan NAD+ na iya haifar da raguwar ƙwayoyin cuta, asarar hangen nesa, kiba, raguwar aikin zuciya da sauran raguwar aiki. Don haka, yadda ake ƙara matakin NAD + a cikin jikin ɗan adam ya kasance koyaushe tambaya. Taken bincike mai zafi a cikin al'ummar likitanci.

Me yasa NAD+ ke raguwa?

Domin, yayin da muke tsufa, lalacewar DNA yana ƙaruwa. Yayin aikin gyaran DNA, buƙatar PARP1 yana ƙaruwa, aikin SIRT yana da iyaka, yawan amfani da NAD + yana ƙaruwa, kuma adadin NAD + yana raguwa.

Idan muka kara wadatarwaNAD+, za mu ga cewa yawancin ayyuka na jiki sun fara dawo da samartaka.

Sel sun ƙunshi NAD+. Shin har yanzu muna buƙatar ƙarawa?

Jikinmu yana da kusan sel tiriliyan 37. Kwayoyin dole ne su kammala yawancin "aiki" ko halayen salula don kula da kansu. Kowace sel ɗin ku tiriliyan 37 ya dogara da NAD+ don yin aikin sa mai gudana.

Yayin da yawan al’ummar duniya ke da shekaru, cututtuka masu alaka da tsufa irin su cutar Alzheimer, cututtukan zuciya, matsalolin haɗin gwiwa, barci da matsalolin zuciya sun zama cututtuka masu muhimmanci da ke barazana ga lafiyar ɗan adam.

Saboda haka, tun lokacin da masana kimiyya na Amurka suka gano NAD, NAD ya shiga cikin rayuwar mutane, kuma NAD + da abubuwan da ke tattare da shi sun nuna kyakkyawan fata na aikace-aikace don rigakafin cututtuka masu alaka da tsufa.

① NAD + yana aiki azaman coenzyme a cikin mitochondria don haɓaka daidaiton rayuwa. NAD + yana taka muhimmiyar rawa a cikin tafiyar matakai na rayuwa kamar glycolysis, zagayowar TCA (aka Krebs sake zagayowar ko citric acid) da kuma sarkar jigilar lantarki. Yadda sel ke samun kuzari. Tsufa da abinci mai yawan kalori suna rage matakan NAD + a cikin jiki.

Nazarin ya nuna cewa a cikin tsofaffin beraye, shan abubuwan NAD + sun rage yawan cin abinci-ko kiba mai alaƙa da haɓaka ƙarfin motsa jiki. Bugu da ƙari, nazarin ya ma sauya tasirin ciwon sukari a cikin berayen mata, yana nuna sabbin dabaru don yaƙar cututtuka na rayuwa kamar kiba.

NAD+ yana ɗaure ga enzymes kuma yana canja wurin electrons tsakanin kwayoyin halitta. Electrons sune tushen makamashin salula. NAD+ yana aiki akan sel kamar yin cajin baturi. Lokacin da aka yi amfani da electrons, baturin ya mutu. A cikin sel, NAD + na iya haɓaka canja wurin lantarki da samar da makamashi ga sel. Ta wannan hanyar, NAD + na iya ragewa ko haɓaka ayyukan enzyme, haɓaka maganganun kwayoyin halitta da siginar tantanin halitta.

② NAD + yana taimakawa sarrafa lalacewar DNA

Yayin da kwayoyin halitta suka tsufa, munanan abubuwan muhalli kamar radiation, gurɓataccen abu, da ƙarancin kwafin DNA na iya lalata DNA. Wannan yana daya daga cikin ka'idodin tsufa. Kusan dukkanin sel suna ɗauke da "na'urorin kwayoyin halitta" don gyara wannan lalacewa.

Wannan gyaran yana buƙatar NAD + da makamashi, don haka lalatawar DNA ta wuce kima tana cinye albarkatun salula masu mahimmanci. Ayyukan PARP, muhimmin furotin gyaran DNA, kuma ya dogara da NAD +. Tsufa na al'ada yana haifar da lalacewar DNA ta tarawa a cikin jiki, RARP yana ƙaruwa, sabili da haka adadin NAD + yana raguwa. Lalacewar DNA na mitochondrial a kowane mataki zai kara tsananta wannan raguwa.

③ NAD+yana rinjayar aikin Sirtuins na tsawon rai kuma yana hana tsufa

Sabbin kwayoyin halittar sirtuin da aka gano, wadanda kuma aka fi sani da “masu kula da kwayoyin halitta,” suna taka muhimmiyar rawa wajen kiyaye lafiyar kwayar halitta. Sirtuins iyali ne na enzymes da ke shiga cikin amsa damuwa ta salula da kuma lalacewa. Suna kuma shiga cikin ɓoyewar insulin, tsarin tsufa, da yanayin kiwon lafiya da suka shafi tsufa kamar cututtukan neurodegenerative da ciwon sukari.

NAD + shine man fetur wanda ke taimakawa sirtuins su kiyaye mutuncin kwayoyin halitta da inganta gyaran DNA. Kamar yadda mota ba za ta iya rayuwa ba tare da man fetur ba, Sirtuins na buƙatar NAD + don kunnawa. Sakamako daga nazarin dabbobi sun nuna cewa haɓaka matakan NAD + a cikin jiki yana kunna sunadaran sirtuin kuma yana ƙara tsawon rayuwa a cikin yisti da mice.

④ Aikin zuciya

Haɓaka matakan NAD + yana kare zuciya kuma yana inganta aikin zuciya. Hawan jini na iya haifar da kara girman zuciya da toshewar arteries wanda zai iya haifar da bugun jini. Bayan sake cika matakin NAD + a cikin zuciya ta hanyar abubuwan NAD +, an hana lalacewar zuciya da ke haifar da maimaitawa. Sauran binciken sun nuna cewa kari na NAD + shima yana kare beraye daga girman girman zuciya.

⑤ Neurodegeneration

A cikin berayen da ke da cutar Alzheimer, haɓaka matakan NAD+ suna haɓaka aikin fahimi ta hanyar rage haɓakar sunadaran da ke lalata sadarwar kwakwalwa. Haɓaka matakan NAD+ kuma yana kare ƙwayoyin kwakwalwa daga mutuwa lokacin da babu isasshen jini da ke gudana zuwa kwakwalwa. NAD + ya bayyana yana da sabon alƙawari don karewa daga neurodegeneration da inganta ƙwaƙwalwar ajiya.

⑥ Tsarin rigakafi

Yayin da muke tsufa, tsarin garkuwar jikin mu yana raguwa kuma mun fi kamuwa da rashin lafiya. Binciken na baya-bayan nan ya nuna cewa matakan NAD + suna taka muhimmiyar rawa wajen daidaita martanin rigakafi da kumburi da rayuwar tantanin halitta yayin tsufa. Binciken ya nuna yiwuwar warkewar NAD + don rashin aikin rigakafi.

Dangantaka tsakanin rawar NAD + da tsufa

Coenzymes suna shiga cikin metabolism na abubuwa masu mahimmanci kamar sukari, kitse, da furotin a cikin jikin ɗan adam, kuma suna taka muhimmiyar rawa wajen daidaita kayan jiki da kuzarin kuzari da kuma kiyaye ayyukan yau da kullun na physiological. NAD shine mafi mahimmancin coenzyme a cikin jikin mutum, wanda kuma ake kira coenzyme I. Yana shiga cikin dubban redox enzymatic halayen a cikin jikin mutum. Abu ne da ba makawa a cikin metabolism na kowane tantanin halitta. Yana da ayyuka da yawa, manyan ayyuka sune:

1. Inganta samar da makamashin halittu

NAD + yana haifar da ATP ta hanyar numfasawa ta salula, haɓaka makamashin tantanin halitta kai tsaye da haɓaka aikin salula;

2. Gyara kwayoyin halitta

NAD + shine kawai maɓalli don gyaran enzyme na DNA na PARP. Irin wannan nau'in enzyme yana shiga cikin gyaran DNA, yana taimakawa wajen gyara DNA da sel da suka lalace, yana rage yiwuwar maye gurbin kwayar halitta, kuma yana hana faruwar ciwon daji;

3. Kunna duk sunadaran tsawon rai

NAD + na iya kunna duk furotin na tsawon lokaci na 7, don haka NAD + yana da tasiri mafi mahimmanci akan rigakafin tsufa da tsawaita rayuwa;

4. Karfafa garkuwar jiki

NAD + yana ƙarfafa tsarin rigakafi kuma yana haɓaka rigakafi ta salon salula ta hanyar zaɓin tasiri ga rayuwa da aikin tsarin ƙwayoyin T.

5. Inganta girman gashi

Babban abin da ke haifar da asarar gashi shine asarar gashi ga mahaifiyar cell, kuma rashin lafiyar uwar cell shine saboda matakin NAD+ a jikin mutum yana raguwa. Kwayoyin uwar gashi ba su da isasshen ATP don aiwatar da haɗin furotin gashi, don haka rasa ƙarfin su kuma yana haifar da asarar gashi.

6. Gudanar da nauyi, inganta metabolism

A cikin 2017, Farfesa David Sinclair na Makarantar Kiwon Lafiya ta Harvard tare da tawagar daga Kwalejin Kiwon Lafiya ta Australiya sun gudanar da gwajin kwatankwacin kan berayen mata masu kiba suna motsa jiki a kan tukwane na tsawon makonni 9 kuma suna ɗaukar NMN kowace rana har tsawon kwanaki 18. Binciken ya gano cewa NMN yana shafar ƙwayar hanta mai hanta. Kuma tasirin kira a fili ya fi na motsa jiki girma.

Musamman ma, tsufa yana tare da raguwar ci gaba a cikin nama da matakan NAD + na salula a cikin nau'ikan kwayoyin halitta iri-iri, gami da rodents da mutane. Ragewar matakan NAD + yana da alaƙa da alaƙa da yawancin cututtukan da ke da alaƙa da tsufa, gami da raguwar fahimi, ciwon daji, cututtukan rayuwa, sarcopenia, da rauni.

Ta yaya zan iya ƙara NAD+ kullum?

Babu wadatar NAD + mara iyaka a jikinmu. Abubuwan da ke ciki da aikin NAD + a cikin jikin mutum zai ragu tare da shekaru, kuma zai ragu da sauri bayan shekaru 30, yana haifar da tsufa na cell, apoptosis da asarar ikon sake farfadowa. .

Haka kuma, raguwar NAD + shima zai haifar da jerin matsalolin lafiya, don haka idan NAD + ba za a iya cika shi cikin lokaci ba, ana iya tunanin sakamakon.

1.Kari daga abinci

Abinci irin su kabeji, broccoli, avocado, nama, namomin kaza, da edamame sun ƙunshi abubuwan da suka faru na NAD +, waɗanda za a iya canza su zuwa NAD * mai aiki a cikin jiki bayan sha.

2.Restrict abinci da adadin kuzari

Matsakaicin ƙuntatawa na caloric na iya kunna hanyoyin gano kuzari a cikin sel kuma a kaikaice ƙara matakan NAD*. Amma ka tabbata ka ci abinci daidai gwargwado don biyan bukatun abinci na jikinka

3. Kasance da aiki da motsa jiki

Matsakaicin motsa jiki na motsa jiki kamar gudu da yin iyo na iya haɓaka matakan NAD + na ciki, taimakawa haɓaka iskar oxygen a cikin jiki da haɓaka haɓakar kuzari.

4. Bi lafiyayyen halayen bacci

A lokacin barci, jikin mutum yana aiwatar da matakai masu mahimmanci na rayuwa da gyaran gyare-gyare, ciki har da haɗin NAD *. Samun isasshen barci yana taimakawa kula da matakan NAD na yau da kullun

5. Ƙarin NAD+ abubuwan farko

Nicotinic acid (NA) da nicotinamide (NAM) su ne magabatan NAD +. Ana iya haɗa su kuma a canza su zuwa NAD a cikin jikin mutum, don haka ƙara abun ciki. Koyaya, saboda iyakancewar hanyar haɗin gwiwa da ƙarancin ƙarancin enzymes, ƙarancin bioavailability yana da ƙasa. .

6 Haɓaka NAD+ kai tsaye

Exogenous kari na NAD + na iya hanzarta dawo da matakan NAD + a cikin jiki, yana barin mahimman gabobin kamar zuciya da ƙwaƙwalwa don samun ƙarin ingantaccen NAD + kari.

Suzhou Myland Pharm & Nutrition Inc. shine masana'anta mai rijista na FDA wanda ke ba da inganci mai inganci da tsaftar NAD + ƙarin foda.

A Suzhou Myland Pharm mun himmatu wajen samar da ingantattun kayayyaki a farashi mafi kyau. Ana gwada foda ɗin mu na NAD + da ƙarfi don tsabta da ƙarfi, yana tabbatar da samun ingantaccen ƙarin abin dogaro da za ku iya amincewa. Ko kuna son tallafawa lafiyar salula, haɓaka tsarin rigakafi ko haɓaka lafiyar gabaɗaya, NAD + kari foda shine cikakken zaɓi.

Tare da shekaru 30 na gwaninta da haɓaka ta hanyar fasaha mai zurfi da ingantattun dabarun R&D, Suzhou Myland Pharm ya haɓaka kewayon samfuran gasa kuma ya zama ƙarin ƙarin ilimin kimiyyar rayuwa, haɗin al'ada da kamfanin sabis na masana'antu.

Bugu da kari, Suzhou Myland Pharm kuma masana'anta ce mai rijista ta FDA. Abubuwan R&D na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma masu aiki da yawa, kuma suna iya samar da sinadarai daga milligrams zuwa ton a sikelin, kuma suna bin ka'idodin ISO 9001 da ƙayyadaddun samarwa GMP.