Me kuke buƙatar sani game da nicotinamide adenine dinucleotide (NAD+)?

Ana kuma kiran NAD+ da coenzyme, kuma cikakken sunansa shine nicotinamide adenine dinucleotide. Yana da muhimmin coenzyme a cikin zagayowar tricarboxylic acid. Yana haɓaka metabolism na sukari, mai, da amino acid, yana shiga cikin haɗakar makamashi, kuma yana shiga cikin dubban martani a cikin kowace ƙwayar halitta. Yawancin bayanai na gwaji sun nuna cewa NAD+ yana da hannu sosai a cikin ayyuka daban-daban na ilimin halittar jiki a cikin kwayoyin halitta, ta haka yana shiga cikin manyan ayyukan ƙwayoyin halitta kamar metabolism na makamashi, gyaran DNA, gyaran kwayoyin halitta, kumburi, rhythms na halitta, da juriya ga damuwa.

A cewar wani bincike da ya dace, matakin NAD+ a jikin ɗan adam zai ragu da shekaru. Rage matakan NAD+ na iya haifar da raguwar jijiyoyi, asarar gani, kiba, raguwar aikin zuciya da sauran raguwar aiki. Saboda haka, yadda ake ƙara matakin NAD+ a jikin ɗan adam koyaushe tambaya ce. Batun bincike mai zafi a cikin al'ummar likitanci.

Me yasa NAD+ ke raguwa?

Domin, yayin da muke tsufa, lalacewar DNA tana ƙaruwa. A lokacin gyaran DNA, buƙatar PARP1 tana ƙaruwa, aikin SIRT yana da iyaka, yawan amfani da NAD+ yana ƙaruwa, kuma adadin NAD+ yana raguwa ta halitta.

Idan muka ƙara isassheNAD+, za mu ga cewa ayyuka da yawa na jiki suna fara dawo da ƙuruciya.

Kwayoyin halitta suna ɗauke da NAD+. Shin har yanzu muna buƙatar ƙara masa?

Jikinmu ya ƙunshi kimanin ƙwayoyin halitta tiriliyan 37. Dole ne ƙwayoyin halitta su kammala ayyukan "aiki" ko na ƙwayoyin halitta da yawa don kula da kansu. Kowanne daga cikin ƙwayoyin halittarku tiriliyan 37 ya dogara ne akan NAD+ don yin aikinsa na ci gaba.

Yayin da yawan jama'a a duniya ke tsufa, cututtuka masu alaƙa da tsufa kamar cutar Alzheimer, cututtukan zuciya, matsalolin gaɓɓai, barci da matsalolin zuciya sun zama manyan cututtuka da ke barazana ga lafiyar ɗan adam.

Saboda haka, tun lokacin da masana kimiyya na Amurka suka gano NAD, NAD ya shiga rayuwar mutane, kuma NAD+ da ƙarin abubuwan da ke cikinsa sun nuna kyakkyawan damar amfani da shi wajen hana cututtukan da suka shafi tsufa.

① NAD+ yana aiki a matsayin coenzyme a cikin mitochondria don haɓaka daidaiton metabolism. NAD+ yana taka rawa musamman a cikin hanyoyin metabolism kamar glycolysis, zagayowar TCA (wanda aka fi sani da zagayowar Krebs ko zagayowar citric acid) da sarkar jigilar lantarki. Wannan shine yadda ƙwayoyin halitta ke samun kuzari. Tsufa da cin abinci mai yawan kalori suna rage matakan NAD+ a jiki.

Bincike ya nuna cewa a cikin tsofaffin beraye, shan kari na NAD+ yana rage yawan kiba da ke da alaƙa da abinci ko tsufa da kuma inganta ƙarfin motsa jiki. Bugu da ƙari, bincike ya ma ya sauya tasirin ciwon suga a cikin beraye mata, yana nuna sabbin dabarun yaƙi da cututtukan metabolism kamar kiba.

NAD+ yana ɗaurewa da enzymes kuma yana canja wurin electrons tsakanin ƙwayoyin halitta. Electrons sune tushen kuzarin ƙwayoyin halitta. NAD+ yana aiki akan ƙwayoyin halitta kamar sake caji baturi. Lokacin da aka yi amfani da electrons, batirin ya mutu. A cikin ƙwayoyin halitta, NAD+ na iya haɓaka canja wurin electrons da samar da makamashi ga ƙwayoyin halitta. Ta wannan hanyar, NAD+ na iya rage ko ƙara ayyukan enzyme, yana haɓaka bayyanar kwayoyin halitta da siginar ƙwayoyin halitta.

② NAD+ yana taimakawa wajen sarrafa lalacewar DNA

Yayin da halittu ke tsufa, abubuwan da ba su dace ba na muhalli kamar radiation, gurɓatawa, da kuma kwafi na DNA mara inganci na iya lalata DNA. Wannan yana ɗaya daga cikin ka'idojin tsufa. Kusan dukkan ƙwayoyin halitta suna ɗauke da "injinan ƙwayoyin halitta" don gyara wannan lalacewar.

Wannan gyaran yana buƙatar NAD+ da kuzari, don haka lalacewar DNA mai yawa yana cinye albarkatun ƙwayoyin halitta masu mahimmanci. Aikin PARP, wani muhimmin furotin na gyaran DNA, shi ma ya dogara da NAD+. Tsufa na yau da kullun yana haifar da lalacewar DNA ta taruwa a jiki, RARP yana ƙaruwa, don haka yawan NAD+ yana raguwa. Lalacewar DNA ta Mitochondrial a kowane mataki zai ƙara ta'azzara wannan raguwar.

③ NAD+yana shafar aikin tsawon rai na kwayar halittar Sirtuins kuma yana hana tsufa

Sabbin kwayoyin halittar da aka gano na tsawon rai, wato sirtuins, waɗanda aka fi sani da "masu kula da kwayoyin halitta," suna taka muhimmiyar rawa wajen kiyaye lafiyar ƙwayoyin halitta. Sirtuins dangin enzymes ne da ke da hannu a cikin mayar da martani ga damuwa da gyaran lalacewar ƙwayoyin halitta. Suna kuma da hannu a cikin fitar da insulin, tsarin tsufa, da kuma matsalolin lafiya da suka shafi tsufa kamar cututtukan neurodegenerative da ciwon suga.

NAD+ man fetur ne da ke taimaka wa sirtuins su riƙe amincin kwayoyin halitta da kuma inganta gyaran DNA. Kamar yadda mota ba za ta iya rayuwa ba tare da mai ba, Sirtuins suna buƙatar NAD+ don kunnawa. Sakamakon binciken dabbobi ya nuna cewa ƙara yawan NAD+ a jiki yana kunna sunadaran sirtuin kuma yana tsawaita tsawon rai a cikin yisti da beraye.

④ Aikin zuciya

Ƙara matakan NAD+ yana kare zuciya da inganta aikin zuciya. Hawan jini na iya haifar da faɗaɗar zuciya da toshewar jijiyoyin jini, wanda zai iya haifar da bugun jini. Bayan cike gurbin NAD+ a cikin zuciya ta hanyar kari na NAD+, lalacewar zuciya da reperfusion ke haifarwa za ta ragu. Wasu bincike sun nuna cewa kari na NAD+ kuma yana kare beraye daga faɗaɗar zuciya mara kyau.

⑤ Rashin lafiyar jijiyoyi

A cikin beraye masu fama da cutar Alzheimer, ƙara matakan NAD+ yana inganta aikin fahimta ta hanyar rage tarin sunadaran da ke kawo cikas ga sadarwa ta kwakwalwa. Ƙara matakan NAD+ kuma yana kare ƙwayoyin kwakwalwa daga mutuwa lokacin da babu isasshen jini da ke kwarara zuwa kwakwalwa. Da alama NAD+ yana da sabon alkawari wajen kare kansa daga cututtukan jijiyoyi da inganta ƙwaƙwalwa.

⑥ Tsarin garkuwar jiki

Yayin da muke tsufa, tsarin garkuwar jikinmu yana raguwa kuma muna fuskantar rashin lafiya. Binciken da aka yi kwanan nan ya nuna cewa matakan NAD+ suna taka muhimmiyar rawa wajen daidaita martanin garkuwar jiki da kumburi da kuma rayuwar ƙwayoyin halitta yayin tsufa. Binciken ya nuna yuwuwar warkewa ta NAD+ don rashin aikin garkuwar jiki.

Alaƙa tsakanin rawar NAD+ da tsufa

Coenzymes suna shiga cikin metabolism na muhimman abubuwa kamar sukari, mai, da furotin a cikin jikin ɗan adam, kuma suna taka muhimmiyar rawa wajen daidaita metabolism na kayan jiki da makamashi da kuma kiyaye ayyukan jiki na yau da kullun. NAD shine mafi mahimmancin coenzyme a cikin jikin ɗan adam, wanda kuma ake kira coenzyme I. Yana shiga cikin dubban halayen redox enzymatic a cikin jikin ɗan adam. Abu ne mai mahimmanci ga metabolism na kowace tantanin halitta. Yana da ayyuka da yawa, manyan ayyuka sune:

1. Inganta samar da makamashin halittu

NAD+ yana samar da ATP ta hanyar numfashin ƙwayoyin halitta, yana ƙara kuzarin ƙwayoyin halitta kai tsaye da kuma inganta aikin ƙwayoyin halitta;

2. Gyara kwayoyin halitta

NAD+ shine kawai tushen enzyme na gyaran DNA PARP. Wannan nau'in enzyme yana shiga cikin gyaran DNA, yana taimakawa wajen gyara DNA da ƙwayoyin da suka lalace, yana rage damar maye gurbin ƙwayoyin halitta, kuma yana hana faruwar cutar kansa;

3. Kunna dukkan furotin masu tsawon rai

NAD+ zai iya kunna dukkan sunadaran tsawon rai guda 7, don haka NAD+ yana da tasiri mafi mahimmanci akan hana tsufa da tsawaita rayuwa;

4. Ƙarfafa tsarin garkuwar jiki

NAD+ yana ƙarfafa tsarin garkuwar jiki kuma yana inganta garkuwar jiki ta hanyar yin tasiri ga rayuwa da aikin ƙwayoyin T masu tsari.

5. Inganta girman gashi

Babban abin da ke haifar da asarar gashi shine asarar kuzarin ƙwayoyin halitta na uwa, kuma asarar kuzarin ƙwayoyin halitta na uwa shine saboda matakin NAD+ a jikin ɗan adam yana raguwa. Kwayoyin halittar uwa ba su da isasshen ATP don gudanar da haɗakar furotin na gashi, wanda hakan ke haifar da asarar kuzarinsu da kuma asarar gashi.

6. Kula da nauyi, inganta metabolism

A shekarar 2017, Farfesa David Sinclair na Makarantar Likitanci ta Harvard da wata tawaga daga Kwalejin Likitanci ta Australia sun gudanar da wani gwaji na kwatantawa kan beraye mata masu kiba suna motsa jiki a kan injin motsa jiki na tsawon makonni 9 da kuma shan NMN kowace rana na tsawon kwanaki 18. Binciken ya gano cewa NMN yana shafar metabolism na kitsen hanta. Kuma tasirin hadawa a bayyane yake ya fi na motsa jiki girma.

Abin lura shi ne, tsufa yana tare da raguwar matakan NAD+ na nama da ƙwayoyin halitta a cikin nau'ikan halittu daban-daban, ciki har da beraye da mutane. Raguwar matakan NAD+ yana da alaƙa da cututtuka da yawa da ke da alaƙa da tsufa, gami da raguwar fahimta, ciwon daji, cututtukan metabolism, sarcopenia, da rauni.

Ta yaya zan iya ƙara NAD+ kowace rana?

Babu isasshen NAD+ a jikinmu. Abubuwan da ke cikin NAD+ da ayyukansa a jikin ɗan adam za su ragu da tsufa, kuma zai ragu da sauri bayan shekaru 30, wanda ke haifar da tsufan ƙwayoyin halitta, apoptosis da kuma asarar ƙarfin sake farfaɗowa.

Bugu da ƙari, raguwar NAD+ zai kuma haifar da jerin matsalolin lafiya, don haka idan ba za a iya sake cika NAD+ akan lokaci ba, ana iya tunanin sakamakon.

1. Karin abinci

Abinci kamar kabeji, broccoli, avocado, nama, namomin kaza, da edamame suna ɗauke da abubuwan da ke haifar da NAD+, waɗanda za a iya mayar da su zuwa NAD* mai aiki a jiki bayan an sha su.

2. Rage cin abinci da kalori

Matsakaicin ƙuntatawa a cikin adadin kuzari na iya kunna hanyoyin da ke sa kuzari ya yi tasiri a cikin ƙwayoyin halitta kuma a kaikaice yana ƙara matakan NAD*. Amma tabbatar da cewa kun ci abinci mai kyau don biyan buƙatun abinci mai gina jiki na jikin ku.

3. Ka kasance mai aiki tukuru kuma ka motsa jiki

Motsa jiki mai matsakaicin motsa jiki kamar gudu da iyo na iya ƙara matakan NAD+ a cikin ƙwayoyin halitta, taimakawa wajen ƙara yawan iskar oxygen a jiki da kuma inganta metabolism na makamashi.

4. Bi hanyoyin barci masu kyau

A lokacin barci, jikin ɗan adam yana gudanar da muhimman hanyoyin metabolism da gyarawa, gami da haɗa NAD*. Samun isasshen barci yana taimakawa wajen kiyaye matakan NAD na yau da kullun.

5. Ƙarin abubuwan da suka riga suka fara aiki na NAD+

Nicotinic acid (NA) da nicotinamide (NAM) dukkansu sune abubuwan da suka fara samar da NAD+. Ana iya haɗa su kuma a mayar da su NAD a cikin jikin ɗan adam, ta haka ne za a ƙara yawan abubuwan da ke cikinsa. Duk da haka, saboda iyakokin hanyar haɗa su da enzymes masu iyakance ƙimar, samuwar halittu ba ta da yawa.

6 Ƙara NAD+ kai tsaye

Ƙarin NAD+ na waje zai iya dawo da matakan NAD+ cikin sauri a cikin jiki, yana bawa muhimman gabobin jiki kamar zuciya da kwakwalwa damar samun ƙarin NAD+ mai inganci.

Suzhou Myland Pharm & Nutrition Inc. kamfani ne da ke da rijistar FDA wanda ke samar da foda mai inganci da tsafta na NAD+.

A Suzhou Myland Pharm, mun himmatu wajen samar da kayayyaki mafi inganci a farashi mafi kyau. Ana gwada foda na NAD+ ɗinmu sosai don tabbatar da tsarki da ƙarfi, wanda ke tabbatar da cewa kun sami ƙarin abinci mai inganci da za ku iya amincewa da shi. Ko kuna son tallafawa lafiyar ƙwayoyin halitta, haɓaka garkuwar jikinku ko haɓaka lafiya gaba ɗaya, foda na NAD+ ɗinmu shine zaɓi mafi kyau.

Tare da shekaru 30 na gwaninta da kuma jagorancin fasaha mai zurfi da dabarun bincike da ci gaba mai kyau, Suzhou Myland Pharm ta ƙirƙiro nau'ikan kayayyaki masu gasa daban-daban kuma ta zama kamfanin ƙarin kimiyya na rayuwa, kera na musamman da ayyukan masana'antu.

Bugu da ƙari, Suzhou Myland Pharm shi ma kamfani ne mai rijistar FDA. Albarkatun bincike da ci gaba na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma suna da ayyuka da yawa, kuma suna iya samar da sinadarai daga milligrams zuwa tan a sikelin, kuma suna bin ƙa'idodin ISO 9001 da ƙayyadaddun bayanai na samarwa na GMP.