Menene 7,8-Dihydroxyflavone kuma Me yasa yakamata ku kula?

7,8-Dihydroxyflavone (7,8-DHF)flavonoid wani abu ne da ke faruwa a zahiri, wani fili na polyphenolic da ake samu a cikin tsirrai iri-iri. Flavonoids an san su da kaddarorin antioxidant kuma suna taka muhimmiyar rawa a hanyoyin kare tsirrai. 7,8-Dihydroxyflavone yana samuwa musamman a cikin tsire-tsire irin su Godmania aesculifolia da Tridax procumbens.

7,8-Dihydroxyflavone ya bambanta da sauran flavonoids a cikin ikonsa na yin kwaikwayi ayyukan da ake samu na neurotrophic factor (BDNF). BDNF furotin ne wanda ke goyan bayan rayuwa, haɓakawa, da aikin neurons a cikin kwakwalwa. Yana taka muhimmiyar rawa a cikin neuroplasticity, ikon kwakwalwa don sake tsara kansa ta hanyar samar da sabbin hanyoyin haɗin gwiwa. Wannan dukiya na 7,8-DHF yana buɗe hanyoyi masu yawa na bincike, musamman a fannin ilimin kimiyya.

Hanyar aiki

Tsarin farko wanda 7,8-Dihydroxyflavone ke aiwatar da tasirin sa shine kunna mai karɓar TrkB (tropomyosin receptor kinase B). TrkB babban mai karɓa ne na BDNF. Lokacin da 7,8-Dihydroxyflavone ya ɗaure zuwa TrkB, yana haifar da jerin hanyoyin siginar siginar ciki wanda ke haɓaka rayuwar neuronal, girma, da bambanci.

Binciken da aka yi na farko ya nuna cewa 7,8-dihydroxyflavone na iya yin koyi da BDNF (factor neurotrophic da aka samu na kwakwalwa) kuma ya kara yawan magana da matakansa a cikin hippocampus. A cikin nau'ikan dabbobi, yana da yuwuwar warkewa don cututtukan jijiya da yawa ko cuta, wato bugun jini, damuwa, da cutar Parkinson. A cikin bincike daban-daban guda biyu, 7,8-dihydroxyflavone ya nuna mahimmancin bioavailability na baka kuma an gano ya ketare shingen jini na kwakwalwa (BBB). Saboda yana aiki akan hanyar siginar nitric oxide kuma yana kunna mai karɓar TrkB (mai karɓar mai karɓar tropomyosin kinase B)

Halin neurotrophic BDNF galibi yana watsa sigina ta hanyar ɗaure ga takamaiman masu karɓa, ta haka yana shafar tsarin ilimin halittar jiki na neurons. Yayin da 7,8-DHF zai iya yin tasiri na tasirin neurotrophic BDNF, mabuɗin ya ta'allaka ne a cikin tsarin hulɗar sa tare da mai karɓar BDNF. Nazarin ya nuna cewa 7,8-DHF na iya ɗaure zuwa BDNF mai karɓar TrkB kuma ya kunna hanyoyin siginar ƙasa.

Musamman, lokacin da 7,8-DHF ya ɗaure zuwa TrkB, yana haifar da jerin abubuwan watsa siginar intracellular. Wannan ya haɗa da kunna kinases sunadaran kamar PI3K/Akt da hanyoyin MAPK/ERK. Kunna waɗannan hanyoyin yana da mahimmanci don haɓaka rayuwar neuronal, girma, da filastik synaptic. Ta hanyar yin kwaikwayon kunna waɗannan hanyoyin ta hanyar BDNF, 7,8-DHF yana taimakawa haɓaka haɓakawar neuronal da juriya ga danniya na waje.

7,8-DHF kuma yana sarrafa maganganun kwayoyin halitta a cikin ƙananan ƙwayoyin cuta. Zai iya rinjayar rubutun kwayoyin halittar da ke da alaƙa da haɓakar haɓaka, neuroprotection da samuwar synapse, ta haka yana kwaikwayon tasirin BDNF a matakin ƙwayoyin cuta. Wannan gyare-gyare na maganganun kwayoyin halitta yana kara tallafawa rawar 7,8-DHF don inganta lafiyar ƙwayoyin cuta.

7,8-Dihydroxyflavone (7,8-DHF) wani flavonoid monophenolic ne tare da tasiri masu yawa. Yana aiki azaman agonist don mai karɓar mai karɓar tyrosine kinase mai karɓar TrkB (Kd=320nM) kuma yana kare TrkB-bayyana neurons daga apoptosis. Factor neurotrophic da aka samu na ƙwaƙwalwa (BDNF) furotin ne tare da tasirin neurotrophic wanda ke da mahimmanci ga samuwar kwakwalwa, koyo da ƙwaƙwalwa.

• Neuroprotection: 7,8-DHF ne neuroprotective a cikin dabba model na Parkinson ta cuta, goyon bayan wani tunanin koyo a cikin mice da kuma juya memory deficits a linzamin kwamfuta model na cutar Alzheimer, da kuma iya inganta mota aiki da kuma tsawanta huntingtin rayuwa lokaci na cuta dabbobi model. BDNF na iya inganta neuroplasticity da rayuwa na neuron, taimaka wa kwakwalwa don samar da sababbin hanyoyin haɗin gwiwa, gyara gazawar ƙwayoyin kwakwalwa, da kare lafiyar ƙwayoyin kwakwalwa. Yana da mahimmanci ga samuwar kwakwalwa, koyo da ƙwaƙwalwar ajiya, kuma yana iya kare kwakwalwa daga rashin fahimta mai alaka da shekaru. Rage iyawar fahimi da kariya daga cututtukan neurodegenerative kamar cutar Alzheimer da cutar Parkinson.

• Yana daidaita rayuwar neuronal: 7,8-DHF na iya ɗaure zuwa TrkB kuma ya kunna hanyoyin siginar ƙasa, kamar hanyoyin PI3K/Akt da MAPK/ERK. Kunna waɗannan hanyoyin yana da mahimmanci don haɓaka rayuwar neuronal, girma da filastik synaptic. muhimmanci. BDNF kuma wani abu ne na neurotrophic wanda zai iya kunna hanyoyin siginar siginar intracellular ta hanyar ɗaure masu karɓar TrkB da haɓaka rayuwa da haɓakar ƙwayoyin cuta.

• Haɓaka filastik synaptic: 7,8-DHF na iya inganta haɓakawa da ƙarfafa synapses ta hanyar kunna masu karɓa na TrkB, don haka inganta ingantaccen watsawar synaptic. Hakanan ana tunanin BDNF don haɓaka haɓakawa da ƙarfafa synapses, don haka haɓaka ingantaccen watsa synapti kuma ta haka haɓaka ƙwarewar koyo da ƙwaƙwalwar ajiya.

• Hanyoyin ilmantarwa da ƙwaƙwalwar ajiya: 7,8-DHF na iya inganta ilmantarwa da ƙwaƙwalwar ajiya a cikin mice, wanda zai iya danganta da tasirinsa akan rayuwa na neuronal da synaptic filastik. BDNF kuma tana taka muhimmiyar rawa wajen koyo da tsarin ƙwaƙwalwar ajiya ta hanyar inganta rayuwar neurons da samuwar synapses, ta haka inganta ilmantarwa da ƙwaƙwalwar ajiya.

• Yana daidaita yanayin yanayi: 7,8-DHF yana da tasirin yanayi-modulating, wanda zai iya zama alaƙa da tasirinsa akan rayuwar neuronal da filastik synaptic. Hakanan ana tunanin BDNF yana taka rawa a cikin ƙa'idodin motsin rai ta hanyar daidaita rayuwar neurons da samuwar synapses, don haka yana shafar maganganun motsin rai.

A taƙaice, 7,8-DHF da BDNF suna da irin wannan tsarin aiki a cikin neuroprotection, daidaita rayuwar neuronal, inganta synaptic plasticity, rinjayar koyo da ƙwaƙwalwar ajiya, da kuma daidaita motsin zuciyarmu.

Suzhou Myland Pharm & Nutrition Inc. masana'anta ne mai rijista na FDA wanda ke ba da inganci mai inganci da tsafta mai inganci 7,8-Dihydroxyflavone.

A Suzhou Myland Pharm mun himmatu wajen samar da ingantattun kayayyaki a farashi mafi kyau. Mu 7,8-Dihydroxyflavone an gwada shi da ƙarfi don tsabta da ƙarfi, yana tabbatar da samun ƙarin ƙarin inganci da za ku iya amincewa. Ko kuna son tallafawa lafiyar salula, haɓaka tsarin rigakafi ko haɓaka lafiyar gabaɗaya, 7,8-Dihydroxyflavone ɗinmu shine cikakken zaɓi.

Tare da shekaru 30 na gwaninta da haɓaka ta hanyar fasaha mai zurfi da ingantattun dabarun R&D, Suzhou Myland Pharm ya haɓaka kewayon samfuran gasa kuma ya zama ƙarin ƙarin ilimin kimiyyar rayuwa, haɗin al'ada da kamfanin sabis na masana'antu.

Bugu da kari, Suzhou Myland Pharm kuma masana'anta ce mai rijista ta FDA. Abubuwan R&D na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma masu aiki da yawa, kuma suna iya samar da sinadarai daga milligrams zuwa ton a sikelin, kuma suna bin ka'idodin ISO 9001 da ƙayyadaddun samarwa GMP.