Menene 7,8-Dihydroxyflavone kuma me yasa ya kamata ku damu?

7,8-Dihydroxyflavone (7,8-DHF)wani sinadari ne na halitta da ake samu a cikin halitta, wani sinadari mai yawan sinadarin polyphenolic da ake samu a cikin nau'ikan tsirrai daban-daban. An san Flavonoids saboda kaddarorin antioxidant kuma suna taka muhimmiyar rawa a cikin hanyoyin kare tsirrai. Ana samun 7,8-Dihydroxyflavone musamman a cikin tsire-tsire kamar Godmania aesculifolia da Tridax procumbens.

7,8-Dihydroxyflavone ya bambanta da sauran flavonoids a cikin ikonsa na kwaikwayon ayyukan neurotrophic factor (BDNF) da aka samo daga kwakwalwa. BDNF furotin ne wanda ke tallafawa rayuwa, ci gaba, da aikin ƙwayoyin jijiyoyi a cikin kwakwalwa. Yana taka muhimmiyar rawa a cikin neuroplasticity, ikon kwakwalwa na sake tsara kanta ta hanyar ƙirƙirar sabbin haɗin jijiyoyi. Wannan siffa ta 7,8-DHF tana buɗe hanyoyi da yawa na bincike, musamman a fannin ilimin jijiyoyi.

Tsarin aiki

Babban hanyar da 7,8-Dihydroxyflavone ke amfani da ita ita ce kunna mai karɓar TrkB (tropomyosin receptor kinase B). TrkB mai karɓar haɗin gwiwa ne mai ƙarfi ga BDNF. Lokacin da 7,8-Dihydroxyflavone ya haɗu da TrkB, yana haifar da jerin hanyoyin siginar ƙwayoyin halitta waɗanda ke haɓaka rayuwa ta jijiyoyi, girma, da bambance-bambance.

Nazarin da aka yi kafin a fara aiki a asibiti ya nuna cewa 7,8-dihydroxyflavone na iya kwaikwayon BDNF (abin da ke haifar da neurotrophic factor) kuma yana ƙara yawan bayyanarsa da matakansa a cikin hippocampus. A cikin samfuran dabbobi, yana da yuwuwar warkewa ga cututtuka ko cututtuka da dama na jijiyoyi, wato bugun jini, damuwa, da cutar Parkinson. A cikin bincike guda biyu daban-daban, 7,8-dihydroxyflavone ya nuna babban wadatar abinci ta baki kuma an gano yana ketare shingen jini na kwakwalwa (BBB). Domin yana aiki akan hanyar siginar nitric oxide kuma yana kunna mai karɓar TrkB (tropomyosin receptor kinase B)

Maganin neurotrophic BDNF galibi yana aika sigina ta hanyar ɗaurewa ga takamaiman masu karɓa, wanda hakan ke shafar tsarin ilimin halittar jijiyoyi. Duk da cewa 7,8-DHF na iya kwaikwayon tasirin sinadarin neurotrophic BDNF, mabuɗin yana cikin tsarin hulɗarsa da mai karɓar BDNF. Bincike ya nuna cewa 7,8-DHF na iya ɗaurewa da mai karɓar BDNF TrkB kuma yana kunna hanyoyin sigina na ƙasa.

Musamman ma, lokacin da 7,8-DHF ya haɗu da TrkB, yana haifar da jerin abubuwan da ke faruwa na watsa siginar cikin ƙwayoyin halitta. Wannan ya haɗa da kunna kinases na furotin kamar hanyoyin PI3K/Akt da MAPK/ERK. Kunna waɗannan hanyoyin yana da mahimmanci don haɓaka rayuwar jijiyoyi, girma, da kuma ƙarfin synaptic. Ta hanyar kwaikwayon kunna waɗannan hanyoyin ta hanyar BDNF, 7,8-DHF yana taimakawa wajen haɓaka daidaitawar jijiyoyi da juriya ga damuwa ta waje.

7,8-DHF kuma yana daidaita bayyanar kwayoyin halitta a cikin jijiyoyi. Yana iya shafar rubutun kwayoyin halitta da suka shafi ci gaban jijiyoyi, kare jijiyoyi da kuma samuwar synapse, ta haka yana kwaikwayon tasirin BDNF a matakin kwayoyin halitta. Wannan tsarin bayyanar kwayoyin halitta yana ƙara tallafawa rawar da 7,8-DHF ke takawa wajen inganta lafiyar jijiyoyi.

7,8-Dihydroxyflavone (7,8-DHF) wani sinadari ne mai kama da monophenolic flavonoid mai tasirin abubuwa da yawa. Yana aiki azaman mai hana ƙwayoyin cuta na tyrosine kinase receptor TrkB (Kd=320nM) kuma yana kare ƙwayoyin cuta masu bayyana TrkB daga apoptosis. Maganin neurotrophic da aka samo daga kwakwalwa (BDNF) furotin ne mai tasirin neurotrophic wanda yake da mahimmanci don samuwar kwakwalwa, koyo da ƙwaƙwalwa.

• Kariyar Jijiyoyi: 7,8-DHF yana kare jijiyoyi a cikin samfuran dabbobi na cutar Parkinson, yana tallafawa koyon motsin rai a cikin beraye kuma yana mayar da ƙarancin ƙwaƙwalwa a cikin samfuran beraye na cutar Alzheimer, kuma yana iya inganta aikin motsa jiki da tsawaita lokacin tsira na dabbobin da ke fama da cutar farauta. BDNF na iya inganta neuroplasticity da rayuwar jijiyoyi, yana taimaka wa kwakwalwa samar da sabbin haɗin jijiyoyi, gyara ƙwayoyin kwakwalwa da suka lalace, da kuma kare ƙwayoyin kwakwalwa masu lafiya. Yana da mahimmanci don samuwar kwakwalwa, koyo da ƙwaƙwalwa, kuma yana iya kare kwakwalwa daga raunin fahimta da ke da alaƙa da shekaru. Rage ƙarfin fahimta da kariya daga cututtukan neurodegenerative kamar cutar Alzheimer da cutar Parkinson.

• Yana daidaita rayuwar jijiyoyi: 7,8-DHF na iya ɗaurewa zuwa TrkB kuma yana kunna hanyoyin sigina na ƙasa, kamar hanyoyin PI3K/Akt da MAPK/ERK. Kunna waɗannan hanyoyin yana da mahimmanci don haɓaka rayuwar jijiyoyi, girma da kuma ƙarfin synaptic. yana da mahimmanci. BDNF kuma wani abu ne na neurotrophic wanda zai iya kunna hanyoyin sigina na cikin jiki ta hanyar ɗaurewa ga masu karɓar TrkB kuma yana haɓaka rayuwa da haɓakar jijiyoyi.

• Inganta ƙarfin synaptic: 7,8-DHF na iya haɓaka samuwar synapsum da ƙarfafa shi ta hanyar kunna masu karɓar TrkB, ta haka ne inganta ingancin watsa synaptic. Ana kuma tsammanin BDNF yana haɓaka samuwar synapsum da ƙarfafa shi, ta haka ne yake ƙara ingancin watsa synaptic kuma yana haɓaka ƙwarewar koyo da ƙwaƙwalwa.

• Tasirin koyo da ƙwaƙwalwa: 7,8-DHF na iya inganta ƙwarewar koyo da ƙwaƙwalwa a cikin beraye, wanda ƙila yana da alaƙa da tasirinsa akan rayuwar jijiyoyi da kuma ƙarfin synaptic. BDNF kuma yana taka muhimmiyar rawa a cikin tsarin koyo da ƙwaƙwalwa ta hanyar haɓaka rayuwar jijiyoyi da samuwar synapses, ta haka yana inganta ƙwarewar koyo da ƙwaƙwalwa.

• Yana daidaita yanayi: 7,8-DHF yana da tasirin daidaita yanayi, wanda zai iya danganta da tasirinsa akan rayuwar jijiyoyi da kuma ƙarfin synaptic. Ana kuma tsammanin BDNF yana taka rawa wajen daidaita motsin rai ta hanyar daidaita rayuwar jijiyoyi da samuwar synapses, wanda hakan ke shafar bayyanar motsin rai.

A taƙaice, 7,8-DHF da BDNF suna da irin waɗannan hanyoyin aiki a cikin karewar jijiyoyi, suna daidaita rayuwar jijiyoyi, suna haɓaka ƙarfin synaptic, suna shafar koyo da ƙwaƙwalwa, da kuma daidaita motsin rai.

Suzhou Myland Pharm & Nutrition Inc. kamfani ne da ke da rijistar FDA wanda ke samar da inganci da tsafta mai inganci 7,8-Dihydroxyflavone.

A Suzhou Myland Pharm, mun himmatu wajen samar da kayayyaki mafi inganci a mafi kyawun farashi. An gwada 7,8-Dihydroxyflavone ɗinmu sosai don tabbatar da tsarki da ƙarfi, wanda ke tabbatar da cewa kun sami ƙarin magani mai inganci da za ku iya amincewa da shi. Ko kuna son tallafawa lafiyar ƙwayoyin halitta, haɓaka garkuwar jikinku ko haɓaka lafiyar gaba ɗaya, 7,8-Dihydroxyflavone ɗinmu shine zaɓi mafi kyau.

Tare da shekaru 30 na gwaninta da kuma jagorancin fasaha mai zurfi da dabarun bincike da ci gaba mai kyau, Suzhou Myland Pharm ta ƙirƙiro nau'ikan kayayyaki masu gasa daban-daban kuma ta zama kamfanin ƙarin kimiyya na rayuwa, kera na musamman da ayyukan masana'antu.

Bugu da ƙari, Suzhou Myland Pharm shi ma kamfani ne mai rijistar FDA. Albarkatun bincike da ci gaba na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma suna da ayyuka da yawa, kuma suna iya samar da sinadarai daga milligrams zuwa tan a sikelin, kuma suna bin ƙa'idodin ISO 9001 da ƙayyadaddun bayanai na samarwa na GMP.