Menene NAD + kuma me yasa kuke buƙatar shi don lafiyar ku?

A cikin duniyar lafiya da lafiya da ke ci gaba da haɓaka, NAD + ya zama babban jigo, yana jan hankalin masana kimiyya da masu sha'awar lafiya iri ɗaya. Amma menene ainihin NAD +? Me yasa yake da mahimmanci ga lafiyar ku? Bari mu ƙarin koyo game da dacewa bayanin da ke ƙasa!

Menene NAD+?

Sunan kimiyya na NAD shine nicotinamide adenine dinucleotide. NAD+ yana cikin kowane tantanin halitta na jikin mu. Yana da mahimmancin metabolite da coenzyme a cikin hanyoyin rayuwa daban-daban. Yana shiga tsakani da shiga cikin matakai daban-daban na nazarin halittu. Fiye da enzymes 300 sun dogara da NAD+ Don aiki.

NAD+shine gajartawar Ingilishi na Nicotinamide adenine dinucleotide. Cikakken sunansa a cikin Sinanci shine nicotinamide adenine dinucleotide, ko Coenzyme I a takaice. A matsayin coenzyme wanda ke watsa ions hydrogen, NAD + yana taka rawa a yawancin al'amuran metabolism na mutum, ciki har da glycolysis, Gluconeogenesis, tricarboxylic acid cycle, da sauransu. ta NAD + suna da alaƙa da tsufa, cututtuka na rayuwa, neuropathy da ciwon daji, ciki har da daidaitawar homeostasis cell, sirtuins da aka sani da "kwayoyin rayuwa mai tsawo", gyaran DNA, PARPs sunadaran iyali da ke da alaka da necroptosis da CD38 wanda ke taimakawa wajen siginar calcium.

NAD+ yana aiki azaman motar bus ɗin jigilar kaya, ɗauke da electrons daga wannan kwayar tantanin halitta zuwa wani. Tare da takwaransa na kwayoyin NADH, yana shiga cikin halayen rayuwa daban-daban ta hanyar musayar lantarki wanda ke samar da adenosine triphosphate (ATP), kwayoyin "makamashi" na jiki.

A taƙaice, NAD + yana da mahimmanci don kiyaye lafiyar jiki da daidaito. Metabolism, redox, kulawar DNA da gyarawa, kwanciyar hankali na kwayoyin halitta, tsarin epigenetic, da dai sauransu duk suna buƙatar sa hannu na NAD +.

Saboda haka, jikinmu yana da babban buƙatun NAD +. Ana ci gaba da haɗa NAD+, rushewa kuma ana sake yin fa'ida a cikin sel don kiyaye matakan NAD+ na salula.

NAD + wani muhimmin bangare ne na ayyukan salula kuma yana shiga cikin samar da makamashi da gyaran DNA, duka biyun suna da alaƙa da tsufa.

1) An rarraba shi a cikin dukkanin kwayoyin jikin mutum kuma yana shiga cikin dubban halayen biocatalytic. Yana iya haɓaka metabolism na sukari, mai da amino acid, kuma yana shiga cikin haɓakar kuzari. Yana da mahimmancin coenzyme da ake bukata ga jikin mutum.

2) NAD + shine kawai abin da ake amfani da shi don coI-cinyewar enzymes (kawai kawai don gyaran enzyme na DNA na PARP, kawai maɗaukaki don furotin Sirtuins na tsawon rai, kuma kawai maɗaukaki na cyclic ADP ribose synthase CD38/157).

Koyaya, yayin da shekaru ke ƙaruwa, matakin NAD + a cikin jiki yana raguwa da sauri. Zai ragu da 50% kowace shekara 20. A kusan shekaru 40, abun ciki na NAD + a cikin jikin mutum shine kawai 25% na abin da yake cikin yara.

Idan kwayoyin jikin mutum ba su da NAD +, rashin aikin mitochondrial ya ragu, ikon gyara lalacewar DNA ya ragu, kuma dangin Sirtuin na gina jiki na tsawon rai kuma ba a kunna shi ba, da dai sauransu. Wadannan abubuwa marasa kyau na iya haifar da apoptosis, cututtukan mutum, tsufa har ma da mutuwa.

Matsayin NAD+ a cikin Lafiyar ku Gabaɗaya

Maganin tsufa

NAD+ yana kula da sadarwar sinadarai tsakanin tsakiya da mitochondria, kuma raunin sadarwa shine muhimmin dalilin tsufa na salula.

NAD + na iya cire karuwar adadin lambobin DNA na kuskure yayin metabolism na sel, kula da maganganun al'ada na al'ada, kula da aikin yau da kullun na sel, da rage tsufa na ƙwayoyin ɗan adam.

Gyara lalacewar DNA

NAD + wani muhimmin abu ne don gyaran enzyme na DNA na PARP, wanda ke da tasiri mai mahimmanci akan gyaran DNA, maganganun kwayoyin halitta, ci gaban kwayar halitta, rayuwar tantanin halitta, sake gina chromosome, da kwanciyar hankali.

Kunna furotin na tsawon rai

Sirtuins galibi ana kiran su dangin furotin na tsawon rai kuma suna taka muhimmiyar rawa a cikin ayyukan tantanin halitta, kamar kumburi, haɓakar tantanin halitta, rhythm na circadian, metabolism makamashi, aikin neuronal, da juriya, kuma NAD + shine muhimmin enzyme don haɓakar sunadaran tsawon rai. .

Yana kunna duk sunadaran 7 na tsawon rai a cikin jikin mutum, yana taka muhimmiyar rawa a juriya ta salon salula, metabolism makamashi, hana maye gurbi, apoptosis da tsufa.

Samar da makamashi

Yana haɓaka samar da fiye da 95% na makamashin da ake buƙata don ayyukan rayuwa. Mitochondria a cikin sel ɗan adam sune tsire-tsire masu ƙarfi na sel. NAD + muhimmin coenzyme ne a cikin mitochondria don samar da kwayoyin makamashi ATP, yana canza abubuwan gina jiki zuwa makamashin da jikin dan adam ke bukata.

Haɓaka farfadowar jigon jini da kula da elasticity na jini

Tasoshin jini sune nama masu mahimmanci don ayyukan rayuwa. Yayin da muke tsufa, jijiyoyin jini a hankali suna rasa sassaucin su kuma suna daɗaɗa ƙarfi, kauri, da kunkuntar, suna haifar da "arteriosclerosis."

NAD + na iya haɓaka aikin elastin a cikin tasoshin jini, ta haka ne ke kiyaye elasticity na tasoshin jini da kuma kula da lafiyar jijiyoyin jini.

Inganta metabolism

Metabolism shine jimlar halayen halayen sinadarai iri-iri a cikin jiki. Jiki zai ci gaba da musayar kwayoyin halitta da makamashi. Lokacin da wannan musayar ya tsaya, rayuwar jiki ma za ta ƙare.

Farfesa Anthony tare da tawagarsa na bincike a Jami'ar California, Amurka, sun gano cewa NAD + na iya inganta yadda ya kamata don rage raguwar ƙwayoyin sel da ke da alaƙa da tsufa, ta yadda za a inganta lafiyar mutane da kuma tsawaita rayuwa.

Kare lafiyar zuciya

Zuciya ita ce mafi mahimmancin sashin jikin ɗan adam, kuma matakin NAD + a cikin jiki yana taka muhimmiyar rawa wajen kiyaye aikin zuciya na yau da kullun.

Ragewar NAD + na iya kasancewa da alaƙa da cututtukan cututtukan cututtukan zuciya da yawa, kuma yawancin karatun asali sun kuma tabbatar da tasirin ƙarin NAD + akan cututtukan zuciya.

Hana cututtukan zuciya da jijiyoyin jini

Bincike ya nuna cewa kusan dukkanin nau'ikan sirtuins guda bakwai (SIRT1-SIRT7) suna da alaƙa da faruwar cututtukan zuciya. Ana ɗaukar Sirtuins a matsayin makasudin agonist don maganin cututtukan zuciya, musamman SIRT1.

NAD + shine kawai madaidaicin madaidaicin Sirtuins. Canjin lokaci na NAD + ga jikin ɗan adam zai iya kunna cikakken aikin kowane nau'in Sirtuins, ta haka yana kare lafiyar zuciya da kuma hana cututtukan zuciya.

Inganta girman gashi

Babban abin da ke haifar da asarar gashi shine asarar gashi ga mahaifiyar cell, kuma rashin lafiyar mahaifiyar cell shine saboda matakin NAD+ a jikin mutum yana raguwa. Kwayoyin uwar gashi ba su da isasshen ATP don aiwatar da haɗin furotin gashi, don haka rasa ƙarfin su kuma yana haifar da asarar gashi.

Don haka, ƙarin NAD + na iya ƙarfafa tsarin acid ɗin kuma ya samar da ATP, ta yadda sel mahaifiyar gashi suna da isasshen ikon samar da furotin gashi, don haka inganta asarar gashi.

Inda za'a Sayi Kariyar Beta-NAD+ Lami lafiya akan layi

Suzhou Myland Pharm & Nutrition Inc. shine masana'anta mai rijista na FDA wanda ke ba da inganci mai inganci da tsaftar NAD + Supplement foda.

A Suzhou Myland Pharm mun himmatu wajen samar da ingantattun kayayyaki a farashi mafi kyau. Mu NAD + Supplement foda an gwada shi da ƙarfi don tsabta da ƙarfi, yana tabbatar da samun ingantaccen ƙarin abin dogaro da za ku iya amincewa. Ko kuna son tallafawa lafiyar salula, haɓaka tsarin rigakafi ko haɓaka lafiyar gabaɗaya, NAD + Supplement foda shine cikakken zaɓi.

Tare da shekaru 30 na gwaninta da haɓaka ta hanyar fasaha mai zurfi da ingantattun dabarun R&D, Suzhou Myland Pharm ya haɓaka kewayon samfuran gasa kuma ya zama ƙarin ƙarin ilimin kimiyyar rayuwa, haɗin al'ada da kamfanin sabis na masana'antu.

Bugu da kari, Suzhou Myland Pharm kuma masana'anta ce mai rijista ta FDA. Abubuwan R&D na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma masu aiki da yawa, kuma suna iya samar da sinadarai daga milligrams zuwa ton a sikelin, kuma suna bin ka'idodin ISO 9001 da ƙayyadaddun samarwa GMP.