Menene NAD+ kuma me yasa kuke buƙatar sa don lafiyar ku?

A cikin duniyar lafiya da walwala da ke ci gaba da bunƙasa, NAD+ ya zama abin mamaki, yana jawo hankalin masana kimiyya da masu sha'awar lafiya. Amma menene ainihin NAD+? Me yasa yake da mahimmanci ga lafiyar ku? Bari mu ƙara koyo game da bayanan da suka dace a ƙasa!

Menene NAD+?

Sunan kimiyya na NAD shine nicotinamide adenine dinucleotide. NAD+ yana wanzuwa a cikin kowace ƙwayar jikinmu. Babban metabolite ne da coenzyme a cikin hanyoyi daban-daban na rayuwa. Yana shiga tsakani da shiga cikin hanyoyin halitta daban-daban. Fiye da enzymes 300 sun dogara da NAD+ Don aiki.

NAD+shine taƙaitaccen bayanin Nicotinamide adenine dinucleotide na Ingilishi. Cikakken sunansa a cikin Sinanci shine nicotinamide adenine dinucleotide, ko Coenzyme I a takaice. A matsayinsa na coenzyme wanda ke watsa ions na hydrogen, NAD+ yana taka rawa a fannoni da yawa na metabolism na ɗan adam, gami da glycolysis, Gluconeogenesis, tricarboxylic acid cycle, da sauransu. Wasu bincike sun nuna cewa raguwar NAD+ yana da alaƙa da shekaru, kuma hanyoyin ilimin halittar jiki da NAD+ ke jagoranta suna da alaƙa da tsufa, cututtukan metabolism, neuropathy da ciwon daji, gami da daidaita homeostasis na tantanin halitta, sirtuins da aka sani da "tsawon kwayoyin halitta", gyara DNA, furotin na iyali na PARPs da ke da alaƙa da necroptosis da CD38 waɗanda ke taimakawa wajen siginar calcium.

NAD+ yana aiki a matsayin motar jigilar kaya, yana ɗaukar electrons daga ƙwayar halitta ɗaya zuwa wani. Tare da takwaransa na kwayoyin halitta NADH, yana shiga cikin halayen rayuwa daban-daban ta hanyar musayar electrons wanda ke samar da adenosine triphosphate (ATP), ƙwayar "makamashi" ta jiki.

A taƙaice dai, NAD+ yana da matuƙar muhimmanci wajen kula da lafiyar jiki da daidaito. Tsarin metabolism, redox, kula da DNA da gyara shi, daidaiton kwayoyin halitta, tsarin epigenetic, da sauransu duk suna buƙatar haɗin NAD+.

Saboda haka, jikinmu yana da buƙatar NAD+ mai yawa. Ana ci gaba da haɗa NAD+, ana rushe shi kuma ana sake yin amfani da shi a cikin ƙwayoyin halitta don kiyaye matakan NAD+ na ƙwayoyin halitta masu ƙarfi.

NAD+ muhimmin bangare ne na ayyukan tantanin halitta kuma yana da hannu wajen samar da makamashi da gyaran DNA, wadanda dukkansu suna da alaƙa da tsufa mai lafiya.

1) Yana yaɗuwa sosai a cikin dukkan ƙwayoyin jikin ɗan adam kuma yana shiga cikin dubban halayen biocatalytic. Yana iya haɓaka metabolism na sukari, mai da amino acid, da kuma shiga cikin haɗakar makamashi. Yana da muhimmin coenzyme da ake buƙata ga jikin ɗan adam.

2) NAD+ shine kawai substrate don enzymes masu cinye coI (substrate kawai don enzyme gyaran DNA PARP, substrate kawai don tsawon rai furotin Sirtuins, kuma kawai substrate don cyclic ADP ribose synthase CD38/157).

Duk da haka, yayin da shekaru ke ƙaruwa, matakin NAD+ a cikin jiki yana raguwa da sauri. Zai ragu da kashi 50% a kowace shekara 20. A kusan shekaru 40, yawan NAD+ a cikin jikin ɗan adam shine kashi 25% kawai na abin da yake a cikin yara.

Idan ƙwayoyin ɗan adam ba su da NAD+, aikin mitochondrial zai ragu, ƙarfin gyaran lalacewar DNA zai ragu, kuma tsawon rai dangin furotin na kwayoyin halitta Sirtuin shi ma ba ya aiki, da sauransu. Waɗannan abubuwan marasa kyau na iya haifar da apoptosis, cututtukan ɗan adam, tsufa har ma da mutuwa.

Matsayin NAD+ a Lafiyar ku gaba ɗaya

Anti-tsufa

NAD+ yana kula da sadarwa ta sinadarai tsakanin tsakiya da mitochondria, kuma raguwar sadarwa muhimmin abu ne da ke haifar da tsufa a cikin ƙwayoyin halitta.

NAD+ zai iya cire yawan lambobin DNA da ke ƙaruwa yayin metabolism na ƙwayoyin halitta, yana kiyaye bayyanar kwayoyin halitta na yau da kullun, yana kiyaye aikin ƙwayoyin halitta na yau da kullun, da kuma rage tsufar ƙwayoyin halittar ɗan adam.

Gyara lalacewar DNA

NAD+ muhimmin abu ne ga enzyme na gyaran DNA PARP, wanda ke da tasiri mai mahimmanci akan gyaran DNA, bayyanar kwayoyin halitta, ci gaban kwayoyin halitta, rayuwar kwayoyin halitta, sake gina kwayoyin halitta, da kuma kwanciyar hankali na kwayoyin halitta.

Kunna furotin na tsawon rai

Sau da yawa ana kiran Sirtuins dangin furotin na tsawon rai kuma suna taka muhimmiyar rawa a cikin ayyukan tantanin halitta, kamar kumburi, haɓakar tantanin halitta, yanayin circadian, metabolism na makamashi, aikin neuronal, da juriya ga damuwa, kuma NAD+ muhimmin enzyme ne don haɗa sunadaran tsawon rai.

Yana kunna dukkan sunadaran tsawon rai guda 7 a jikin dan adam, yana taka muhimmiyar rawa wajen juriya ga damuwa ta hanyar kwayoyin halitta, metabolism na makamashi, hana maye gurbi a cikin kwayoyin halitta, apoptosis da tsufa.

Samar da makamashi

Yana haɓaka samar da fiye da kashi 95% na kuzarin da ake buƙata don ayyukan rayuwa. Mitochondria a cikin ƙwayoyin ɗan adam sune tsire-tsire masu ƙarfi na ƙwayoyin halitta. NAD+ muhimmin coenzyme ne a cikin mitochondria don samar da ƙwayar makamashi ta ATP, yana canza abubuwan gina jiki zuwa makamashin da jikin ɗan adam ke buƙata.

Inganta farfaɗo da jijiyoyin jini da kuma kula da sassaucin jijiyoyin jini

Jijiyoyin jini suna da matuƙar muhimmanci ga ayyukan rayuwa. Yayin da muke tsufa, jijiyoyin jini a hankali suna rasa sassaucinsu kuma suna yin tauri, kauri, da kuma kunkuntar, wanda ke haifar da "arteriosclerosis."

NAD+ na iya ƙara yawan aikin elastin a cikin jijiyoyin jini, ta haka yana kiyaye sassaucin jijiyoyin jini da kuma kiyaye lafiyar jijiyoyin jini.

Inganta metabolism

Tsarin narkewar abinci shine jimlar halayen sinadarai daban-daban a cikin jiki. Jiki zai ci gaba da musayar abubuwa da kuzari. Idan wannan musayar ta tsaya, rayuwar jiki ma za ta ƙare.

Farfesa Anthony da tawagar bincikensa a Jami'ar California, Amurka, sun gano cewa NAD+ na iya inganta raguwar metabolism na ƙwayoyin halitta da ke da alaƙa da tsufa yadda ya kamata, ta haka ne za a inganta lafiyar mutane da kuma tsawaita rayuwarsu.

Kare lafiyar zuciya

Zuciya ita ce mafi mahimmancin gaɓɓar ɗan adam, kuma matakin NAD+ a cikin jiki yana taka muhimmiyar rawa wajen kiyaye aikin zuciya yadda ya kamata.

Rage NAD+ na iya kasancewa da alaƙa da cututtukan zuciya da jijiyoyin jini da yawa, kuma adadi mai yawa na bincike na asali sun kuma tabbatar da tasirin ƙarin NAD+ akan cututtukan zuciya.

Hana cututtukan zuciya da jijiyoyin jini

Bincike ya nuna cewa kusan dukkan nau'ikan sirtuins guda bakwai (SIRT1-SIRT7) suna da alaƙa da faruwar cututtukan zuciya da jijiyoyin jini. Ana ɗaukar Sirtuins a matsayin abubuwan da ke haifar da cutar zuciya da jijiyoyin jini, musamman SIRT1.

NAD+ shine kawai tushen Sirtuins. Ƙara NAD+ akan lokaci ga jikin ɗan adam zai iya kunna aikin kowane nau'in Sirtuins gaba ɗaya, ta haka yana kare lafiyar zuciya da jijiyoyin jini da kuma hana cututtukan zuciya.

Inganta girman gashi

Babban abin da ke haifar da asarar gashi shine asarar kuzarin ƙwayoyin halitta na uwa, kuma asarar kuzarin ƙwayoyin halitta na uwa shine saboda matakin NAD+ a jikin ɗan adam yana raguwa. Kwayoyin halittar uwa ba su da isasshen ATP don gudanar da haɗakar furotin na gashi, wanda hakan ke haifar da asarar kuzarinsu da kuma asarar gashi.

Saboda haka, ƙara NAD+ zai iya ƙarfafa zagayowar acid da kuma samar da ATP, ta yadda ƙwayoyin uwayen gashi za su sami isasshen ƙarfin samar da furotin na gashi, ta haka ne za a inganta asarar gashi.

Inda za a Sayi Karin Beta-NAD+ Lafiya akan Layi

Suzhou Myland Pharm & Nutrition Inc. kamfani ne da ke da rijistar FDA wanda ke samar da foda mai inganci da tsafta mai yawa na NAD+.

A Suzhou Myland Pharm, mun himmatu wajen samar da kayayyaki mafi inganci a farashi mafi kyau. Ana gwada foda na NAD+ Supplement ɗinmu sosai don tabbatar da tsarki da ƙarfi, wanda ke tabbatar da cewa kun sami ƙarin abinci mai inganci da za ku iya amincewa da shi. Ko kuna son tallafawa lafiyar ƙwayoyin halitta, haɓaka garkuwar jikinku ko haɓaka lafiya gaba ɗaya, foda na NAD+ Supplement ɗinmu shine zaɓi mafi kyau.

Tare da shekaru 30 na gwaninta da kuma jagorancin fasaha mai zurfi da dabarun bincike da ci gaba mai kyau, Suzhou Myland Pharm ta ƙirƙiro nau'ikan kayayyaki masu gasa daban-daban kuma ta zama kamfanin ƙarin kimiyya na rayuwa, kera na musamman da ayyukan masana'antu.

Bugu da ƙari, Suzhou Myland Pharm shi ma kamfani ne mai rijistar FDA. Albarkatun bincike da ci gaba na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma suna da ayyuka da yawa, kuma suna iya samar da sinadarai daga milligrams zuwa tan a sikelin, kuma suna bin ƙa'idodin ISO 9001 da ƙayyadaddun bayanai na samarwa na GMP.