Menene spermidine? Jagora mai sauƙi ga spermidine

Spermidinewani nau'in polyamin ne. Polyamines ƙananan ne, masu kitse, polycationic (-NH3+) kwayoyin halitta. Akwai manyan polyamines guda hudu a cikin dabbobi masu shayarwa: spermine, spermidine, putrescine da cadaverine. Maniyyi na tetramines ne, spermidine na cikin triamines, putrescine da cadaverine na cikin diamines. Lambobi daban-daban na rukunonin amino suna ba su kaddarorin ilimin lissafi daban-daban.

Spermidine a cikin mutane

Spermidine ba kawai yana wanzuwa a cikin maniyyi ba, amma kuma yana yaduwa a cikin sauran kyallen takarda da kwayoyin jikin mutum. Matsalolin spermidine na intracellular ya dogara ne akan abubuwa hudu:

① Haɗin cikin salula:

Arginine → putrescine → spermidine ← maniyyi. Arginine shine babban albarkatun kasa don haɗin spermidine a cikin sel. An catalyzed ta hanyar arginase don samar da ornithine da urea. Ana amfani da Ornithine don samar da putrescine a ƙarƙashin aikin ornithine decarboxylase (ODC1). Wannan shine matakin iyakacin iyaka), putrescine yana haifar da spermidine a ƙarƙashin aikin spermidine synthase (SPDS). Hakanan ana iya samar da Spermidine ta hanyar lalatawar maniyyi.

②Kwantar da wayar salula:

Rarraba cikin abincin abinci da haɗin ƙwayoyin ƙwayoyin cuta na hanji. Abincin da ke cikin maniyyi ya haɗa da ƙwayar alkama, natto, waken soya, namomin kaza, da sauransu. Maniyyi da maniyyi da ake sha daga abinci suna saurin shanyewa daga hanji kuma ana rarrabawa ba tare da lalacewa ba, don haka yawan ƙwayar spermidine a cikin jini yana da hankali sosai. Kwayoyin ƙwayoyin cuta a cikin microbiota na hanji kamar Bifidobacterium kuma suna iya haɗa spermidine.

③ Catabolism:

Maniyyi a cikin jiki yana raguwa a hankali zuwa spermidine da putrescine ta hanyar N1-acetyltransferase (SSAT), polyamine oxidase (PAO) da sauran amine oxidases, yayin da putrescine kuma ya zama aminobutyric acid ta hanyar oxidases. A ƙarshe, amine ions da carbon dioxide ana haifar da su daga jiki.

④ Shekaru:

Matsalolin spermidine yana canzawa tare da shekaru. Masu bincike sun auna yawan ƙwayar polyamines a cikin kyallen takarda daban-daban da gabobin ɗan mako 3, mai mako 10 da 26 mai mako 26 kuma sun gano cewa ana kiyaye shi a cikin pancreas, kwakwalwa da mahaifa. Canje-canje a cikin hanji yana raguwa kaɗan da shekaru, kuma yana raguwa sosai a cikin thymus, splin, ovary, hanta, ciki, huhu, koda, zuciya da tsoka. Ba shi da wahala a gare mu mu yi hasashe cewa dalilan wannan canjin sun haɗa da canje-canjen abinci, canje-canje a cikin tsarin flora na hanji, rage ayyukan polyamine synthase, da dai sauransu.

Manufar dabi'a na spermidine

Me yasa irin wannan ƙananan ƙananan ƙwayoyin cuta ya zama mahimmin abu mai mahimmanci ga jikin ɗan adam? Asiri a zahiri yana cikin tsarinsa: Spermidine shine polycationic (-NH3+) fatty amine ƙananan ƙwayoyin cuta waɗanda ke wanzuwa a cikin nau'i mai nau'in protonated a ƙarƙashin yanayin pH na jiki, tare da ions masu kyau waɗanda aka rarraba cikin sarkar carbon. Lantarki cajin, yana da karfi physiological aiki.

Saboda haka, ko yana da nucleic acid, phospholipids, acidic sunadaran dauke da acidic sharan gona, pectic polysaccharides dauke da carboxyl kungiyoyin da sulfates, ko neurotransmitters da kuma hormones (dopamine, epinephrine, serotonin, thyroid hormone, da dai sauransu) tare da irin wannan tsarin, Yiwuwar manufa ga spermidine. ɗaure. Mafi mahimmanci sune:

Acid Nucleic:

Nazarin ya gano cewa yawancin polyamines suna wanzuwa a cikin nau'in hadaddun polyamine-RNA a cikin sel, tare da 1-4 daidai da polyamine da aka ɗaure kowane daidai 100 na mahadi na phosphate. Sabili da haka, babban aikin spermidine yana da alaƙa da sauye-sauyen tsari da fassarar RNA, kamar rinjayar matakai daban-daban na haɗin furotin ta hanyar tasiri na biyu na mRNA, tRNA da rRNA. Spermidine kuma na iya samar da tsayayyen “gadaji” tsakanin igiyoyin DNA masu ƙarfi biyu, rage damar samun radicals kyauta ko wasu abubuwan da ke lalata DNA, da kare DNA daga ƙarancin zafi da hasken X-ray.

②Protein:

Spermidine na iya ɗaure ga sunadaran da ke ɗauke da manyan zarge-zarge kuma suna canza yanayin yanayin furotin, wanda hakan ke shafar aikin sa na jiki. Misalan sun haɗa da kinases na furotin / phosphatases (mahimmin hanyar haɗi a cikin hanyoyi masu yawa na siginar sigina), enzymes da ke cikin histone methylation da acetylation (wanda ke shafar maganganun kwayoyin halitta ta hanyar canza epigenetics), acetylcholinesterase (wani muhimmin sashi na cututtuka na neurodegenerative). daya daga cikin magungunan warkewa), masu karɓar tashar tashar ion (kamar AMPA, masu karɓar AMDA), da dai sauransu.

Suzhou Myland shine masana'anta mai rijista na FDA wanda ke ba da inganci mai inganci da tsaftar Spermidine foda.

A Suzhou Myland, mun himmatu wajen samar da ingantattun kayayyaki a farashi mafi kyau. Ana gwada foda ɗin mu na Spermidine da ƙarfi don tsabta da ƙarfi, yana tabbatar da samun ƙarin ƙarin inganci da za ku iya amincewa. Ko kuna son tallafawa lafiyar salula, haɓaka tsarin rigakafi ko haɓaka lafiyar gabaɗaya, Spermidine foda shine cikakken zaɓi.

Tare da shekaru 30 na gwaninta da haɓaka ta hanyar fasaha mai zurfi da ingantaccen dabarun R&D, Spermidine ya haɓaka kewayon samfuran gasa don zama ingantaccen ƙarin ilimin kimiyyar rayuwa, haɗin al'ada da kamfanin sabis na masana'antu.

Bugu da kari, Suzhou Myland ma masana'anta ce mai rijista ta FDA. Abubuwan R&D na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma masu aiki da yawa, kuma suna da ikon samar da sinadarai daga milligrams zuwa ton a sikelin, kuma suna bin ka'idodin ISO 9001 da ƙayyadaddun samarwa GMP.