Menene spermidine? Jagora mai sauƙi game da spermidine

Man shafawawani nau'in polyamine ne. Polyamines ƙanana ne, masu kitse, polycationic (-NH3+). Akwai manyan polyamines guda huɗu a cikin dabbobi masu shayarwa: spermine, spermidine, putrescine da cadaverine. Spermine na cikin tetramines, spermidine na cikin triamines, putrescine da cadaverine na cikin diamines. Adadi daban-daban na ƙungiyoyin amino suna ba su halaye daban-daban na ilimin halittar jiki.

Spermidine a cikin mutane

Ba wai kawai spermidine yana wanzuwa a cikin maniyyi ba, har ma yana yaɗuwa sosai a cikin wasu kyallen jiki da ƙwayoyin jikin ɗan adam. Yawan spermidine a cikin ƙwayoyin halitta ya dogara ne akan abubuwa huɗu:

①Haɗakar ƙwayoyin halitta:

Arginine → putrescine → spermidine ← spermine. Arginine shine babban kayan da ake amfani da shi wajen hada spermidine a cikin ƙwayoyin halitta. Arginase yana haɓaka shi don samar da ornithine da urea. Sannan ana amfani da Ornithine don samar da putrescine a ƙarƙashin aikin ornithine decarboxylase (ODC1). Wannan shine matakin iyakance ƙimar), putrescine yana samar da spermidine a ƙarƙashin aikin spermidine synthase (SPDS). Hakanan ana iya samar da spermidine ta hanyar lalacewar spermine.

②Ɗaukar ƙwayoyin halitta daga waje:

An raba shi zuwa abinci da kuma haɗa ƙwayoyin cuta na hanji. Abincin da ke ɗauke da spermidine ya haɗa da ƙwayar alkama, natto, waken soya, namomin kaza, da sauransu. Spermine da spermidine da aka ci daga abinci suna sha da sauri daga hanji kuma suna yaɗuwa ba tare da lalacewa ba, don haka yawan spermidine a cikin jini. Tarin ƙwayoyin cuta sun bambanta sosai. Kwayoyin cuta masu amfani da probiotic a cikin ƙwayoyin cuta na hanji kamar Bifidobacterium suma suna iya haɗa spermidine.

③Katabolism:

Ana rage yawan sinadarin maniyyi a jiki ta hanyar N1-acetyltransferase (SSAT), polyamine oxidase (PAO) da sauran amine oxidases, yayin da ake ƙara canza putrescine zuwa aminobutyric acid ta hanyar oxidases. A ƙarshe, ana samar da amine ions da carbon dioxide daga jiki kuma ana fitar da su daga jiki.

④Shekaru:

Yawan maniyyi yana canzawa da shekaru. Masu bincike sun auna yawan polyamines a cikin kyallen takarda da gabobin beraye 'yan makonni 3, makonni 10 da makonni 26 kuma sun gano cewa galibi ana kiyaye shi a cikin pancreas, kwakwalwa da mahaifa. Canje-canje a cikin hanji yana raguwa kaɗan da shekaru, kuma yana raguwa sosai a cikin thymus, saifa, kwai, hanta, ciki, huhu, koda, zuciya da tsoka. Ba abu ne mai wahala a gare mu mu yi hasashe cewa dalilan wannan canjin sun haɗa da canje-canje a cikin abinci, canje-canje a cikin tsarin flora na hanji, raguwar aikin polyamine synthase, da sauransu.

Manufar halitta ta spermidine

Me yasa irin wannan ƙaramin ƙwayar halitta mai sauƙi take da mahimmanci ga jikin ɗan adam? Sirrin a zahiri yana cikin tsarinsa: Spermidine ƙaramin ƙwayar amine ce mai kitse mai yawan polycationic (-NH3+) wacce ke wanzuwa a cikin nau'i mai yawa a ƙarƙashin yanayin pH na jiki, tare da ions masu kyau da aka rarraba a cikin sarkar carbon. Cajin wutar lantarki, yana da ƙarfin aikin jiki.

Saboda haka, ko dai nucleic acid ne, phospholipids, sunadaran acidic dauke da ragowar acidic, pectic polysaccharides dauke da carboxyl groups da sulfates, ko neurotransmitters da hormones (dopamine, epinephrine, serotonin, thyroid hormone, da sauransu) masu irin wannan tsari, Akwai yiwuwar a yi amfani da spermidine wajen ɗaure spermidine. Wadanda suka fi muhimmanci sune:

2. Sinadarin Nuklia:

Bincike ya gano cewa yawancin polyamines suna wanzuwa a cikin nau'in hadaddun polyamine-RNA a cikin ƙwayoyin halitta, tare da daidaito 1-4 na polyamine da aka ɗaure a kowace daidai 100 na mahaɗan phosphate. Saboda haka, babban aikin spermidine yana da alaƙa da canje-canjen tsari da fassarar RNA, kamar shafar matakai daban-daban na haɗa furotin ta hanyar shafar tsarin sakandare na mRNA, tRNA da rRNA. Spermidine kuma yana iya samar da "gadaje" masu karko tsakanin zaren DNA mai helical guda biyu, rage damar samun free radicals ko wasu abubuwan da ke lalata DNA, da kuma kare DNA daga thermal denaturation da X-ray radiation.

②Sunadaran:

Spermidine na iya ɗaurewa da sunadaran da ke ɗauke da manyan caji marasa kyau kuma yana canza yanayin sararin furotin, wanda hakan ke shafar aikinsa na jiki. Misalan sun haɗa da kinases/phosphatases na furotin (muhimmin haɗi a cikin hanyoyin watsa sigina da yawa), enzymes da ke da hannu a cikin histone methylation da acetylation (yana shafar bayyanar kwayoyin halitta ta hanyar canza epigenetics), acetylcholinesterase (muhimmin sashi na cututtukan neurodegenerative). ɗaya daga cikin magungunan warkewa), masu karɓar tashar ion (kamar AMPA, masu karɓar AMDA), da sauransu.

Suzhou Myland kamfani ne da aka yi wa rijista a hukumar FDA wanda ke samar da foda na Spermidine mai inganci da tsafta.

A Suzhou Myland, mun himmatu wajen samar da mafi kyawun kayayyaki masu inganci a farashi mafi kyau. Ana gwada foda na Spermidine ɗinmu sosai don tabbatar da tsarki da ƙarfi, yana tabbatar da cewa kun sami ƙarin kayan abinci mai inganci da za ku iya amincewa da su. Ko kuna son tallafawa lafiyar ƙwayoyin halitta, haɓaka garkuwar jikinku ko haɓaka lafiyar gaba ɗaya, foda na Spermidine ɗinmu shine zaɓi mafi kyau.

Tare da shekaru 30 na gwaninta da kuma jagorancin fasaha mai zurfi da kuma dabarun bincike da ci gaba mai kyau, Spermidine ta ƙirƙiro nau'ikan kayayyaki masu gasa don zama kamfanin ƙarin kimiyya na rayuwa mai ƙirƙira, kera na musamman da ayyukan masana'antu.

Bugu da ƙari, Suzhou Myland ita ma masana'anta ce da FDA ta yi rijista. Albarkatun bincike da ci gaba na kamfanin, wuraren samarwa, da kayan aikin nazari na zamani ne kuma suna da ayyuka da yawa, kuma suna da ikon samar da sinadarai daga milligrams zuwa tan a sikelin, kuma suna bin ƙa'idodin ISO 9001 da ƙayyadaddun bayanai na samarwa na GMP.