Menene telomerase activator-cycloastraganol da aka gano a halin yanzu?

A shekarar 1985, Greider da abokan aikinsa sun fara gano telomerase, kuma wannan sabon enzyme da aka gano zai iya ƙara maimaita DNA a ƙarshen chromosomes don kiyaye tsawon telomere. Telomerase wani hadadden ribonucleoprotein ne wanda zuciyarsa ta ƙunshi TERT da TERC, wanda TERT shine mabuɗin daidaita ayyukan telomerase. Tsawon telomere yana ci gaba da raguwa yayin da ƙwayoyin halitta ke rabuwa. Lokacin da ya kai wani muhimmin ƙima, yana haifar da siginar lalacewar DNA, wanda ke haifar da gajarta zagayowar ƙwayoyin halitta da kuma jerin cututtukan gazawar kyallen takarda waɗanda ke ɗauke da gajerun telomeres.

A shekarar 2010, kamfanin Amurka Geron ya yi aiki tare da Jami'ar Kimiyya da Fasaha ta Hong Kong a wani aikin bincike don tantance masu kunna telomerase. An gano cewacycloastraganolyana iya kunna ayyukan telomerase da kuma haifar da faɗaɗa telomere. Wannan binciken ya haɓaka ci gaban masu kunna telomerase. Ci gaban bincike da haɓaka samfuran da suka shafi astragalus barasa. Cycloastragenol (CAG) a halin yanzu shine kawai mai kunna telomerase da aka ruwaito a tsakanin samfuran halitta. Yana iya yaƙi da rage telomere yadda ya kamata kuma yana da maganin tsufa, maganin apoptosis, maganin fibrosis, tsarin garkuwar jiki, haɓaka yaɗuwar ƙwayoyin halitta da warkar da rauni, da sauransu. Tasirin magunguna, don haka yana da yuwuwar tasirin warkewa akan cututtukan da suka shafi rashin aikin telomere.

Cycloastragenol da tsufa

telomeres
Telomeres tsari ne na musamman a ƙarshen ƙwayoyin halitta waɗanda ke kare ƙwayoyin halitta kuma suna gajarta ta hanyar kwafi da rarraba ƙwayoyin halitta. Kwayoyin halitta kuma suna tsufa yayin da ƙwayoyin halitta ke gajarta.

telomerase
Telomerase na iya haɗa telomeres don daidaita tsayi da tsarin telomeres, ta haka ne ke kare ƙwayoyin halittar chromosomes da kuma jinkirta tsufar ƙwayoyin halitta.

Maganin tsufa: Wani abu ne mai kunna telomerase, wanda ke taka rawa wajen hana tsufa ta hanyar ƙara yawan telomerase sannan kuma yana jinkirta rage yawan telomeres.

Telomeres murabba'ai ne da ke a ƙarshen ƙwayoyin halitta waɗanda ke kare su daga lalacewa yayin rabuwar ƙwayoyin halitta. Yayin da ƙwayoyin halitta ke ci gaba da rabuwa, telomeres suna ci gaba da raguwa, suna kaiwa ga wani muhimmin matsayi inda ƙwayoyin halitta za su tsufa ko su mutu. Telomerase na iya tsawaita tsawon telomeres, kuma tsawon rayuwar ƙwayoyin halitta zai ƙaru daidai gwargwado.

Tsufa wani ɓangare ne na rayuwa wanda ba makawa; duk da haka, masu bincike suna nazarin magunguna iri-iri don ƙoƙarin guje wa wasu tasirin tsufa, gami da nazarin senolytics. Senolytics sune mahaɗan da ke kawar da ƙwayoyin tsufa (tsufa) kuma an nuna cewa suna rage tasirin tsufa. Wani sabon bincike ya nuna cewa cycloastraganol yana da tasirin hana tsufa.

Binciken, wanda aka yi daga China kuma aka buga a cikin Mujallar Kimiyyar Molecular ta Duniya, ya mayar da hankali kan ƙwayoyin halittar ɗan adam masu tsufa da beraye masu tsufa da radiation ke haifarwa. Cycloastragenol yana rage ƙwayoyin halittar tsufa ba tare da shafar ƙwayoyin halittar da ba sa tsufa ba. Maganin Cycloastragenol kuma yana rage sunadaran da ke cikin ƙwayoyin halittar tsufa waɗanda ake buƙata don girma da rayuwa. Bugu da ƙari, yana hana motsin ƙwayoyin halitta da ke da alaƙa da ƙwayoyin halittar kumburi da ke da alaƙa da shekaru. An gano cewa beraye masu tsufa da aka yi wa magani da cycloastraganol suna da ƙarancin ƙwayoyin halittar tsufa da kuma ingantaccen aikin jiki da ke da alaƙa da tsufa.

Cycloastragenol yana rage tsufan ƙwayoyin halitta

Tsufa alama ce da aka sani ta tsufa, amma masu bincike sun gano cewa kawar da ƙwayoyin tsufa da ƙwayoyin da ke haifar da kumburi na iya taimakawa wajen hana cututtuka masu alaƙa da tsufa har ma da juya su a wasu lokuta. A nan, masu bincike sun yi wa ƙwayoyin ɗan adam magani da cycloastraganol kuma sun gano cewa yana kawar da ƙwayoyin tsufa yadda ya kamata ba tare da shafar ƙwayoyin da ba sa tsufa ba. Bugu da ƙari, alamun ƙwayoyin halitta na ƙwayoyin tsufa sun ragu sosai bayan maganin cycloastraganol.

Binciken da aka yi a baya ya nuna cewa hanyar PI3K/AKT/mTOR—wata hanyar sigina da ke da hannu a cikin girma da rayuwa ta ƙwayoyin halitta—tana da hannu a cikin hanyoyin kumburi da ƙwayoyin tsufa suka fara, wanda ke taimakawa wajen haɓaka tsufa a cikin ƙwayoyin da ke kewaye. Masu binciken sun gano cewa cycloastragenol ya taimaka wajen rage sunadaran da ke cikin wannan hanyar, yana nuna cewa mahaɗin na iya aiki ta hanyar toshe hanyar PI3K/AKT/mTOR don taimakawa hana tsufa. Bugu da ƙari, an nuna cewa cycloastragenol yana rage ikon ƙwayoyin tsufa don haɓaka tsufa ta hanyar sakin ƙwayoyin kumburi, abubuwan da ke haifar da girma, da immunomodulators, daidai da shawarwarin cewa rage siginar PI3K, AKT, da mTOR na iya rage tasirin da ke haɓaka tsufa a tsakanin ƙwayoyin da ke kewaye.

Cycloastragenol na cikin saponins na triterpene kuma galibi ana samunsa ne daga hydrolysis na astragaloside IV. Yana da ƙaramin nauyin kwayoyin halitta da ƙarfi na lipophilicity, wanda ke da amfani ga shigar biofilm da sha na ciki don cimma ingantaccen samuwar bioavailability. Ingancin cycloastragalinol
1. Maganin lalacewar kwakwalwa
2. Inganta fibrosis na hanta
3. Maganin osteoporosis
4. Tasirin hana tsufa
5. Jinkirin tsufar ƙwayoyin halitta

Me yasa ake buƙatar haɗa cycloastraganol?

① Cycloastraganol yana da tasirin magunguna daban-daban kamar hana apoptosis na ƙwayoyin kwakwalwa da kumburin jijiyoyi yayin ischemia na kwakwalwa da kuma kiyaye shingen jini-kwakwalwa.
② Cycloastragenol shine kawai ƙaramin mahaɗin terpenoid na ƙwayoyin halitta wanda aka gano zuwa yanzu kuma yana iya magance cututtukan neurodegenerative.
③ Yana da tasirin hana fibrosis na zuciya da kuma inganta garkuwar jiki ta hana ƙari. Yana da sanannen kwayar halitta a cikin bincike da haɓaka magungunan hana tsufa.

Matsalolin da ke akwai

Abubuwan da ke cikin cycloastraganol a cikin membrane na Astragalus suna da ƙarancin yawa kuma yana da wuya a same shi kai tsaye. Tsarin samar da cycloastraganol da ake da shi ya dogara ne akan cire magungunan gargajiya na ƙasar Sin, wanda galibi ana samunsa ta hanyar canza astragaloside IV a cikin membrane na Astragalus. Wato, ana samun astragaloside IV ta hanyar shuka astragalus da fasahar al'adun nama, sannan a mayar da astragaloside IV zuwa cycloastragaloside ta amfani da acidolysis, lalata Smith, enzyme da microbial hydrolysis. Duk da haka, waɗannan hanyoyin shiri suna da tsada, suna da sauƙin haifar da gurɓataccen muhalli, suna da wahalar rabawa da tsarkakewa, kuma ba sa taimakawa wajen amfani da su da haɓaka su. Saboda haka, mutane sun mayar da hankalinsu ga haɗakar cycloastraganol ta wucin gadi.

Yadda ake amfani da ilmin halittar roba don hadawa? ---Biology na roba

Ilimin Halittar Halitta yana nufin ƙira da aka yi niyya, canji, har ma da ƙirƙirar "rai na wucin gadi" tare da ayyuka marasa kyau a ƙarƙashin jagorancin ra'ayoyin injiniya, wato, injiniyan ilmin halitta. Gabaɗaya, ana samar da shi ta amfani da hanyoyin halittu.