Calcium Alpha ketoglutarate (AKG) matsakaicin metabolite ne na zagaye na tricarboxylic acid kuma yana shiga cikin haɗin amino acid, bitamin da acid Organic da metabolism makamashi. Ana iya amfani dashi azaman kari na abinci kuma yana da fa'idodin aikace-aikace. Baya ga ayyukan ilimin halitta a cikin jikin mutum, ana kuma amfani da calcium alpha-ketoglutarate sosai a fannin harhada magunguna kuma ya zama muhimmin sashi na samfuran kiwon lafiya da yawa da hanyoyin magani.
Menene alpha-ketoglutarate?
AKG wani abu ne na tsaka-tsakin tsaka-tsakin yanayi wanda ke faruwa a zahiri wanda wani bangare ne na zagayowar Krebs, ma'ana jikin mu ne ke samar da shi. Kariyar masana'antar kuma tana samar da sigar roba wacce ke da alaƙa da sinadarai iri ɗaya da AKG ta halitta.
Menene AKG ke yi?
AKG kwayar halitta ce da ke da hannu a yawancin hanyoyin rayuwa da salon salula. Yana aiki a matsayin mai ba da gudummawar kuzari, mai ƙididdigewa don samar da amino acid da ƙwayoyin siginar tantanin halitta, kuma shine mai daidaita hanyoyin tafiyar hawainiya. Yana da maɓalli mai mahimmanci a cikin zagayowar Krebs, yana daidaita saurin zagaye na citric acid na kwayoyin halitta. Yana aiki a hanyoyi daban-daban a cikin jiki don taimakawa wajen gina tsoka da kuma taimakawa wajen warkar da raunuka, wanda shine daya daga cikin dalilan da ya fi shahara a duniyar ginin jiki.
Har ila yau, AKG yana aiki a matsayin mai hana nitrogen, yana hana yawan nitrogen da hana haɓakar ammonia da yawa. Har ila yau, babban tushen glutamate da glutamine, wanda ke motsa furotin a cikin tsokoki da kuma hana lalatawar furotin.
Bugu da ƙari, yana daidaita 10-11 translocation (TET) enzyme da ke cikin DNA demethylation da Jumonji C yankin da ke dauke da lysine demethylase, wanda shine babban histone demethylase. Ta wannan hanyar, ɗan wasa ne mai mahimmanci a cikin ƙa'idar tsarin halitta da magana.
Shin AKG na iya jinkirta tsufa?
Akwai shaidar cewa AKG na iya rinjayar tsufa, kuma yawancin bincike sun nuna cewa haka lamarin yake. Wani bincike na 2014 ya nuna cewa AKG ya tsawaita tsawon rayuwar C. elegans da kusan 50% ta hanyar hana ATP synthase da manufa na rapamycin (TOR).
A cikin wannan binciken, mun gano cewa AKG ba kawai yana ƙara tsawon rayuwa ba amma kuma yana jinkirta wasu abubuwan da suka shafi shekaru, kamar hasara na motsin jiki mai sauri wanda aka saba da shi a cikin tsofaffin C. elegans. Don fahimtar yadda AKG ke shafar tsufa, za mu bayyana hanyoyin da AKG ke hana ATP synthase da TOR don tsawaita rayuwa a cikin C. elegans da yiwuwar wasu nau'in.
Yadda calcium alpha-ketoglutarate ke aiki
Na farko, calcium alpha-ketoglutarate yana taka muhimmiyar rawa wajen samar da makamashi. A matsayin matsakaicin samfur na sake zagayowar acid tricarboxylic (TCA), alli α-ketoglutarate yana shiga cikin tsarin samar da makamashi na ciki. Ta hanyar sake zagayowar TCA, abubuwan gina jiki irin su carbohydrates, fats, da sunadarai suna oxidized kuma sun lalace don samar da ATP (adenosine triphosphate) don samar da makamashi ga sel. A matsayin mahimmancin tsaka-tsaki a cikin sake zagayowar TCA, calcium α-ketoglutarate na iya inganta haɓakar makamashin tantanin halitta, ƙara yawan ƙarfin jiki, taimakawa haɓaka ƙarfin jiki da juriya, da inganta gajiyar jiki.
Na biyu, calcium α-ketoglutarate yana taka muhimmiyar rawa a cikin metabolism na amino acid. Amino acid su ne ainihin raka'o'in furotin, kuma calcium α-ketoglutarate yana shiga cikin jujjuyawa da haɓakar amino acid. A cikin tsarin juya amino acid zuwa wasu metabolites, calcium α-ketoglutarate yana watsawa da amino acid don samar da sababbin amino acid ko α-keto acid, don haka daidaita daidaito da amfani da amino acid. Bugu da kari, calcium α-ketoglutarate kuma zai iya zama madaidaicin iskar oxygen don amino acid, shiga cikin metabolism na oxidative na amino acid, da samar da makamashi da carbon dioxide. Sabili da haka, calcium α-ketoglutarate yana da matukar mahimmanci wajen kiyaye homeostasis na amino acid da furotin a cikin jiki.
Bugu da ƙari, calcium alpha-ketoglutarate yana aiki a matsayin antioxidant wanda ke lalata radicals kyauta kuma yana kare kwayoyin halitta daga lalacewar oxidative. A lokaci guda, calcium α-ketoglutarate kuma yana iya daidaita aikin tsarin garkuwar jiki, haɓaka kunnawa da haɓaka ƙwayoyin rigakafi, da haɓaka juriyar jiki ga cututtuka da kamuwa da cuta. Don haka, calcium α-ketoglutarate yana da matukar mahimmanci wajen kiyaye ma'auni na rigakafi na jiki da kuma tsayayya da cututtuka.
Bincike akan tasirin calcium α-ketoglutarate akan tsufa
Tsufa ya shafe mu duka kuma yana da haɗari ga cututtuka da yawa, kuma bisa ga ƙididdigar masana'antu na Medicare, yiwuwar kamuwa da rashin lafiya yana ƙaruwa da shekaru.
Calcium alpha-ketoglutarate wani muhimmin metabolite ne a cikin jikinmu, wanda aka sani da rawar tantanin halitta a cikin sake zagayowar Krebs, sake zagayowar da ke da mahimmanci ga oxidation na fatty acid da amino acid, barin mitochondria don samar da ATP (ATP shine tushen makamashi na sel).
Wanne ya haɗa da ɗaukar nauyin tsari na alpha-ketoglutarate, don haka calcium alpha-ketoglutarate kuma za'a iya canza shi zuwa glutamate sannan kuma ya zama glutamine, wanda zai iya taimakawa wajen haɓaka haɗin furotin da collagen (collagen shine furotin mai fibrous wanda ya ƙunshi 1/3). na duk furotin a cikin jiki kuma yana taimakawa wajen tallafawa lafiyar kashi, fata da tsoka).
Calcium α-ketoglutarate, azaman ƙarin kayan aikin abinci mai gina jiki, yana da fa'idodin aikace-aikace a cikin samfuran kula da lafiya. Ayyukansa na halitta daban-daban kamar antioxidant, anti-tsufa, tsarin rigakafi da amino acid metabolism sun sa ya zama kayan aiki mai ƙarfi don inganta lafiyar ɗan adam. Tare da karuwar wayar da kan jama'a game da kiwon lafiya da zurfafa bincike na kimiyya, an yi imanin cewa yin amfani da calcium na α-ketoglutarate a fagen kiwon lafiya zai sami karin hankali da ci gaba.
Disclaimer: Wannan labarin don cikakken bayani ne kawai kuma bai kamata a fassara shi azaman kowane shawarar likita ba. Wasu daga cikin bayanan post ɗin suna fitowa daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin rarrabuwa, tsarawa da gyara labarai kawai. Manufar isar da ƙarin bayani baya nufin kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abun cikinsa. Koyaushe tuntuɓi ƙwararrun kula da lafiya kafin amfani da kowane kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin aikawa: Oktoba-15-2024
