Calcium Alpha ketoglutarate (AKG) wani abu ne mai matsakaicin sinadarin tricarboxylic acid metabolite kuma yana shiga cikin hada amino acid, bitamin da kuma Organic acid da kuma metabolism na makamashi. Ana iya amfani da shi azaman kari na abinci kuma yana da fa'ida mai faɗi. Baya ga ayyukansa na halitta a jikin ɗan adam, ana kuma amfani da calcium alpha-ketoglutarate sosai a fannin magunguna kuma ya zama muhimmin sashi na kayayyakin kiwon lafiya da magunguna da yawa.
Menene alpha-ketoglutarate?
AKG wani sinadari ne na halitta wanda ke faruwa a cikin jiki wanda ke cikin zagayowar Krebs, ma'ana jikinmu yana samar da shi. Masana'antar kari kuma tana samar da sigar roba wacce take kama da AKG da aka samar ta halitta.
Me AKG ke yi?
AKG wani kwayar halitta ce da ke da hannu a cikin hanyoyi daban-daban na rayuwa da kuma hanyoyin tantanin halitta. Yana aiki a matsayin mai ba da makamashi, mai ba da tsari ga samar da amino acid da kuma siginar tantanin halitta, kuma mai daidaita hanyoyin epigenetic ne. Babban kwayar halitta ce a cikin zagayowar Krebs, tana daidaita saurin zagayowar citric acid na kwayar halitta gaba ɗaya. Yana aiki a hanyoyi daban-daban a cikin jiki don taimakawa wajen gina tsoka da kuma taimakawa wajen warkar da rauni, wanda shine ɗayan dalilan da ya sa ya shahara a duniyar gina jiki.
AKG kuma yana aiki a matsayin mai tara sinadarin nitrogen, yana hana yawan sinadarin nitrogen da kuma hana tarin sinadarin ammonia mai yawa. Haka kuma babban tushen glutamate da glutamine ne, wanda ke ƙarfafa haɗakar furotin a cikin tsokoki kuma yana hana lalacewar furotin.
Bugu da ƙari, yana daidaita enzyme na 10-11 translocation (TET) da ke da hannu a cikin demethylation na DNA da lysine demethylase mai ɗauke da yankin Jumonji C, wanda shine babban histone demethylase. Ta wannan hanyar, yana da muhimmiyar rawa a cikin tsara kwayoyin halitta da bayyana su.
Shin AKG zai iya jinkirta tsufa?
Akwai shaida cewa AKG na iya shafar tsufa, kuma bincike da yawa sun nuna cewa haka lamarin yake. Wani bincike na 2014 ya nuna cewa AKG ya tsawaita rayuwar manyan C. elegans da kusan kashi 50% ta hanyar hana ATP synthase da kuma manufa ta rapamycin (TOR).
A cikin wannan binciken, mun gano cewa AKG ba wai kawai yana tsawaita tsawon rai ba ne, har ma yana jinkirta wasu nau'ikan halittu masu alaƙa da shekaru, kamar asarar saurin motsin jiki mai tsari wanda aka saba gani a cikin tsofaffin C. elegans. Don fahimtar yadda AKG ke shafar tsufa, za mu bayyana hanyoyin da AKG ke hana ATP synthase da TOR tsawaita tsawon rai a cikin C. elegans da wataƙila wasu nau'ikan.
Yadda Calcium alpha-ketoglutarate ke aiki
Da farko, calcium alpha-ketoglutarate yana taka muhimmiyar rawa a cikin metabolism na makamashi. A matsayinsa na matsakaicin samfurin zagayowar tricarboxylic acid (TCA cycle), calcium α-ketoglutarate yana shiga cikin tsarin samar da makamashi a cikin ƙwayoyin halitta. Ta hanyar zagayowar TCA, abubuwan gina jiki kamar carbohydrates, fats, da sunadarai ana oxidize su kuma suna ruɓewa don samar da ATP (adenosine triphosphate) don samar da makamashi ga ƙwayoyin halitta. A matsayin muhimmin matsakaici a cikin zagayowar TCA, calcium α-ketoglutarate na iya haɓaka metabolism na makamashin ƙwayoyin halitta, ƙara matakin kuzarin jiki, taimakawa wajen haɓaka ƙarfi da juriya, da inganta gajiya ta jiki.
Abu na biyu, calcium α-ketoglutarate yana taka muhimmiyar rawa a cikin metabolism na amino acid. Amino acid sune ginshiƙan furotin, kuma calcium α-ketoglutarate yana da hannu a cikin canzawa da metabolism na amino acid. A cikin tsarin canza amino acid zuwa wasu metabolites, calcium α-ketoglutarate yana canzawa tare da amino acid don samar da sabbin amino acid ko α-keto acid, don haka yana daidaita daidaito da amfani da amino acid. Bugu da ƙari, calcium α-ketoglutarate kuma yana iya zama madadin oxidation ga amino acid, shiga cikin metabolism na oxidative na amino acid, da samar da makamashi da carbon dioxide. Saboda haka, calcium α-ketoglutarate yana da matukar muhimmanci wajen kiyaye homeostasis na amino acid da metabolism na furotin a cikin jiki.
Bugu da ƙari, calcium alpha-ketoglutarate yana aiki a matsayin maganin hana kumburi wanda ke tattara ƙwayoyin cuta masu guba kuma yana kare ƙwayoyin halitta daga lalacewar oxidative. A lokaci guda, calcium α-ketoglutarate kuma yana iya daidaita aikin tsarin garkuwar jiki, yana haɓaka kunnawa da yaɗuwar ƙwayoyin garkuwar jiki, da kuma haɓaka juriyar jiki ga cututtuka da kamuwa da cuta. Saboda haka, calcium α-ketoglutarate yana da matuƙar muhimmanci wajen kiyaye daidaiton garkuwar jiki da kuma juriya ga cututtuka.
Bincike kan tasirin sinadarin calcium α-ketoglutarate akan tsufa
Tsufa yana shafar mu duka kuma yana haifar da haɗari ga cututtuka da yawa, kuma bisa ga ƙididdigar masana'antar Medicare, yuwuwar kamuwa da rashin lafiya yana ƙaruwa da shekaru.
Calcium alpha-ketoglutarate muhimmin metabolite ne a jikinmu, wanda aka sani da rawar da tantanin halitta ke takawa a cikin zagayowar Krebs, zagayowar da ke da mahimmanci don iskar shaka na kitse da amino acid, wanda ke ba da damar mitochondria ta samar da ATP (ATP shine tushen kuzarin ƙwayoyin halitta).
Wanda ya ƙunshi ɗaukar nauyin tsarin calcium alpha-ketoglutarate, don haka ana iya canza calcium alpha-ketoglutarate zuwa glutamate sannan zuwa glutamine, wanda zai iya taimakawa wajen haɓaka haɗakar furotin da collagen (collagen furotin ne mai fibrous wanda ke samar da kashi 1/3 na dukkan furotin a jiki kuma yana taimakawa wajen tallafawa lafiyar ƙashi, fata da tsoka).
Calcium α-ketoglutarate, a matsayin ƙarin abinci mai gina jiki mai aiki da yawa, yana da fa'idodi masu yawa na amfani a cikin kayayyakin kiwon lafiya. Ayyukansa na halitta daban-daban kamar maganin hana tsufa, maganin hana tsufa, daidaita garkuwar jiki da kuma metabolism na amino acid sun sa ya zama kayan aiki mai ƙarfi don inganta lafiyar ɗan adam. Tare da ƙaruwar wayar da kan jama'a game da kiwon lafiya da zurfafa binciken kimiyya, ana kyautata zaton cewa amfani da sinadarin α-ketoglutarate a fannin kayayyakin kiwon lafiya zai sami ƙarin kulawa da ci gaba.
Bayanin Kariya: Wannan labarin don bayanai ne kawai kuma bai kamata a fassara shi a matsayin wata shawara ta likita ba. Wasu daga cikin bayanan da aka wallafa a shafin yanar gizo sun fito ne daga Intanet kuma ba ƙwararru ba ne. Wannan gidan yanar gizon yana da alhakin tsarawa, tsarawa da kuma gyara labarai kawai. Manufar isar da ƙarin bayani ba yana nufin cewa kun yarda da ra'ayoyinsa ko tabbatar da sahihancin abubuwan da ke ciki ba. Kullum ku tuntuɓi ƙwararren likita kafin amfani da duk wani kari ko yin canje-canje ga tsarin kula da lafiyar ku.
Lokacin Saƙo: Oktoba-15-2024
