Me yasa yakamata ku sayi foda na Spermidine? An Bayyana Mahimman Fa'idodin

Spermidine,wanda kuma aka sani da spermidine, wani abu ne na triamine polyamine wanda ake samunsa sosai a cikin tsire-tsire kamar alkama, waken soya, da dankali, ƙananan ƙwayoyin cuta irin su lactobacilli da bifidobacteria, da ƙwayoyin dabbobi daban-daban. Spermidine hydrocarbon ne tare da kwarangwal ɗin carbon mai siffar zigzag wanda ya ƙunshi ƙwayoyin carbon guda 7 da ƙungiyoyin amino a ƙarshen duka da kuma a tsakiya.

Bincike na zamani ya tabbatar da cewa spermidine yana da hannu a cikin muhimman matakai na rayuwa kamar kwayar halittar DNA ta salula, fassarar mRNA, da fassarar furotin, da kuma matakai masu yawa na pathophysiological irin su kariyar danniya na jiki da metabolism. Yana da kariya ta zuciya da jijiyoyin jini da kuma neuroprotection, anti-tumor, da ka'idojin kumburi, da dai sauransu. Muhimmancin ayyukan nazarin halittu.

Ana daukar Spermidine a matsayin mai kunnawa autophagy, tsarin sake yin amfani da kwayar cutar ta cikin salula ta hanyar da tsofaffin kwayoyin halitta suka sabunta kansu kuma su sake samun aiki. Spermidine yana taka muhimmiyar rawa wajen aikin sel da rayuwa. A cikin jiki, spermidine yana samuwa ne daga precursor putrescine, wanda kuma shi ne farkon wani polyamine da ake kira maniyyi, wanda kuma yana da mahimmanci ga aikin tantanin halitta.

Spermidine da putrescine suna ƙarfafa autophagy, tsarin da ke rushe sharar gida da sake yin amfani da kayan aikin salula kuma shine tsarin kula da inganci don mitochondria, gidajen wutar lantarki. Autophagy yana rushewa kuma yana zubar da mitochondria mai lalacewa ko maras kyau, kuma zubar da mitochondrial tsari ne mai ƙarfi. Polyamines suna iya ɗaure su da nau'ikan kwayoyin halitta daban-daban, suna sa su zama masu dacewa. Suna tallafawa matakai kamar haɓakar tantanin halitta, kwanciyar hankali na DNA, haɓakar tantanin halitta, da apoptosis. Polyamines sun bayyana suna aiki daidai da abubuwan haɓakawa yayin rarrabawar tantanin halitta, wanda shine dalilin da yasa putrescine da spermidine ke da mahimmanci ga haɓaka da aikin nama mai lafiya.

Masu bincike sun yi nazari kan yadda spermidine ke kare kwayoyin halitta daga damuwa mai guba, wanda zai iya lalata kwayoyin halitta kuma ya haifar da cututtuka daban-daban. Sun gano cewa spermidine yana kunna autophagy. Binciken ya gano wasu mahimman kwayoyin halitta da spermidine ya shafa wanda ke rage yawan danniya da kuma inganta autophagy a cikin wadannan kwayoyin halitta. Bugu da ƙari, sun gano cewa toshe hanyar mTOR, wanda yawanci ke da hannu wajen hana autophagy, yana kara inganta tasirin kariya na spermidine.

Wadanne abinci ne suke da yawan sinadarin spermidine?

Spermidine shine polyamine mai mahimmanci. Bugu da ƙari, kasancewar jikin ɗan adam da kansa ya samar da shi, wadataccen kayan abinci da ƙananan ƙwayoyin hanji su ma mahimman hanyoyin samar da kayayyaki ne. Yawan spermidine a cikin abinci daban-daban ya bambanta sosai, tare da ƙwayar alkama sanannen tushen shuka. Sauran hanyoyin cin abinci sun haɗa da ganyayen inabi, kayan waken soya, wake, masara, hatsi gabaɗaya, chickpeas, Peas, koren barkono, broccoli, lemu, koren shayi, bran shinkafa da barkono sabo. Bugu da kari, abinci irin su namomin kaza na shiitake, tsaba amaranth, farin kabeji, cuku mai girma da durian suma sun ƙunshi spermidine.

Yana da kyau a lura cewa abinci na Bahar Rum yana ƙunshe da abinci mai yawa na spermidine, wanda zai iya taimakawa wajen bayyana abin da ake kira "blue zone" inda mutane suka fi tsayi a wasu wurare. Duk da haka, ga mutanen da ba za su iya cinye isasshen spermidine ta hanyar abinci ba, abubuwan da ake amfani da su na spermidine hanya ce mai tasiri. spermidine a cikin wadannan kari shine kwayoyin halittar da ke faruwa ta dabi'a, yana mai da shi madadin inganci.

Menene putrescine?

Samar da putrescine ya ƙunshi hanyoyi guda biyu, duka biyun suna farawa da amino acid arginine. A cikin hanyar farko, an fara canza arginine zuwa agmatine catalyzed ta hanyar arginine decarboxylase. Daga baya, agmatine yana ƙara canzawa zuwa N-carbamoylputrescine ta hanyar aikin agmatine iminohydroxylase. Daga ƙarshe, N-carbamoylputrescine an canza shi zuwa putrescine, yana kammala tsarin canji. Hanya na biyu yana da sauƙi mai sauƙi, kai tsaye yana canza arginine zuwa ornithine, sa'an nan kuma ya canza ornithine zuwa putrescine ta hanyar aikin ornithine decarboxylase. Ko da yake waɗannan hanyoyi guda biyu suna da matakai daban-daban, dukansu biyu sun cimma nasarar canzawa daga arginine zuwa putrescine.

Putrescine diamin ne da ake samu a wasu gabobin jiki kamar su pancreas, thymus, fata, kwakwalwa, mahaifa da ovaries. Hakanan ana samun Putrescine a cikin abinci kamar ƙwayar alkama, barkono kore, waken soya, pistachios, da lemu. Binciken da aka yi kwanan nan ya nuna cewa putrescine wani muhimmin abu ne na tsarin rayuwa wanda zai iya yin hulɗa tare da macromolecules na halitta irin su DNA mara kyau, RNA, daban-daban ligands (kamar β1 da β2 adrenergic receptors), da kuma sunadaran membrane. , yana haifar da jerin sauye-sauye na ilimin lissafi ko ilimin cututtuka a cikin jiki.

Spermidine sakamako

Ayyukan Antioxidant: Spermidine yana da aikin antioxidant mai ƙarfi kuma yana iya amsawa tare da radicals kyauta don rage lalacewar oxidative ga sel waɗanda ke haifar da radicals kyauta. A cikin jiki, spermidine kuma na iya haɓaka maganganun enzymes antioxidant da haɓaka ƙarfin antioxidant.

Tsarin metabolism na makamashi: Spermidine yana da hannu wajen daidaita tsarin makamashi na kwayoyin halitta, yana iya haɓaka sha da amfani da glucose bayan cin abinci, kuma yana shafar rabon metabolism na aerobic da metabolism anaerobic ta hanyar daidaita tasirin samar da makamashi na mitochondrial.

anti-mai kumburi sakamako

Spermidine yana da tasirin anti-mai kumburi kuma yana iya daidaita maganganun abubuwan da ke haifar da kumburi da rage abin da ya faru na kumburi na yau da kullun. Yawanci yana da alaƙa da hanyar factor factor-κB (NF-κB).

Girma, haɓakawa da tsarin rigakafi: Spermidine kuma yana taka muhimmiyar rawa wajen haɓaka, haɓakawa da tsarin rigakafi. Yana iya inganta siginar girma hormone a cikin jikin mutum da kuma taimakawa wajen bunkasa ci gaban daban-daban kyallen takarda da gabobin jiki. Haka kuma, a cikin tsarin rigakafi, spermidine yana haɓaka juriya na jiki ga ƙwayoyin cuta da cututtuka ta hanyar daidaita samar da fararen jini da inganta kawar da nau'in iskar oxygen.

Jinkirta tsufa: Spermidine na iya haɓaka autophagy, tsarin tsaftacewa a cikin sel wanda ke taimakawa cire ƙwayoyin cuta da sunadarai masu lalacewa, don haka jinkirta tsufa.

Tsarin sel glial: Spermidine yana taka muhimmiyar rawa wajen daidaitawa a cikin ƙwayoyin glial. Zai iya shiga cikin tsarin siginar kwayar halitta da haɗin aiki tsakanin ƙwayoyin jijiya, kuma yana taka muhimmiyar rawa wajen daidaitawa a cikin ci gaban neuron, watsa synaptic, da juriya ga neuropathy.

Kariyar zuciya: A cikin filin zuciya da jijiyoyin jini, spermidine na iya rage tarin lipid a cikin plaques na atherosclerotic, rage hawan jini na zuciya, da inganta aikin diastolic, don haka samun kariya ta zuciya. Bugu da ƙari, cin abinci na spermidine yana inganta hawan jini kuma yana rage cututtuka na zuciya da kuma mace-mace.

A cikin 2016, bincike da aka buga a Atherosclerosis ya tabbatar da cewa spermidine na iya rage tarin lipid a cikin plaques na atherosclerotic. A cikin wannan shekarar, wani binciken da aka buga a Nature Medicine ya tabbatar da cewa maniyyi na iya rage yawan hawan jini da inganta aikin diastolic, ta haka ne ya kare zuciya da kuma kara tsawon rayuwar berayen.

Inganta cutar Alzheimer

Shan Spermidine yana da amfani ga aikin ƙwaƙwalwar ɗan adam. Tawagar Farfesa Reinhart daga Ostiraliya ta gano cewa maganin spermidine zai iya inganta aikin fahimtar tsofaffi. Binciken ya yi amfani da ƙirar makafi biyu na tsakiya da yawa kuma ya shigar da tsofaffi 85 a cikin gidajen kulawa guda 6, waɗanda aka raba su cikin ƙungiyoyi biyu ba tare da izini ba kuma sun yi amfani da allurai daban-daban na spermidine. An kimanta aikin su na fahimi ta hanyar gwaje-gwajen ƙwaƙwalwar ajiya kuma an raba su zuwa ƙungiyoyi hudu: babu ciwon hauka, rashin jin daɗi mai sauƙi, matsakaicin rashin ƙarfi da rashin ƙarfi mai tsanani. An tattara samfuran jini don tantance yawan maniyyi a cikin jininsu. Sakamakon ya nuna cewa maida hankali ne mai dangantaka da hankali ga aikin fahimta a cikin kungiyar da ba ta dace ba, da kuma fahimta matakin tsofaffi da yawa bayan shigar da allurai na maniyyi.

Ciwon kai

Spermidine na iya inganta autophagy, irin su mTOR (manufa na rapamycin) hanyar hanawa. Ta hanyar inganta autophagy, yana taimakawa wajen kawar da lalata kwayoyin halitta da sunadarai a cikin sel kuma yana kula da lafiyar kwayar halitta.

Ana amfani da Spermidine hydrochloride a fannoni daban-daban

A cikin magunguna, ana amfani da spermidine hydrochloride a matsayin maganin hepatoprotective wanda zai iya inganta aikin hanta da rage lalacewar hanta. Bugu da ƙari, ana iya amfani da spermidine hydrochloride don magance yanayi irin su high cholesterol, hypertriglyceridemia, da cututtukan zuciya.

Spermidine hydrochloride yana aiki ta hanyar rage matakan plasma homocysteine ​​​​(Hcy), don haka rage haɗarin cututtukan zuciya. Nazarin ya nuna cewa spermidine hydrochloride zai iya inganta metabolism na Hcy kuma ya rage hadarin cututtukan zuciya ta hanyar rage matakan Hcy na plasma.

Wani bincike kan illar spermidine hydrochloride akan hadarin cututtukan zuciya ya nuna cewa spermidine hydrochloride zai iya rage matakan Hcy na plasma, ta yadda zai rage hadarin cututtukan zuciya. A cikin binciken, masu bincike sun raba mahalarta zuwa kungiyoyi biyu, tare da ɗaya yana karɓar ƙarin maganin spermidine hydrochloride kuma ɗayan yana karɓar placebo.

Sakamakon binciken ya nuna cewa mahalarta wadanda suka karbi maganin spermidine hydrochloride suna da ƙananan matakan Hcy na plasma da kuma raguwa daidai a cikin hadarin cututtukan zuciya. Bugu da ƙari, akwai wasu nazarin da ke tallafawa rawar spermidine hydrochloride don rage haɗarin cututtukan zuciya.

A cikin filin abinci, ana amfani da spermidine hydrochloride azaman mai haɓaka dandano da humectant don haɓaka ɗanɗanon abinci da kula da ɗanɗanon abinci. Bugu da kari, spermidine hydrochloride kuma za a iya amfani da a matsayin abinci ƙari don inganta girma kudi da tsoka ingancin dabbobi.

A cikin kayan shafawa, ana amfani da spermidine hydrochloride a matsayin humectant da antioxidant don kula da danshi na fata da kuma rage lalacewar free radical. Bugu da ƙari, spermidine hydrochloride kuma za a iya amfani da shi a cikin hasken rana don rage lalacewar hasken ultraviolet ga fata.

A fannin aikin gona, ana amfani da spermidine hydrochloride a matsayin mai kula da haɓakar shuka don haɓaka haɓakar amfanin gona da haɓaka amfanin gona.