Me Ya Sa Ya Kamata Ku Sayi Foda Mai Ƙanƙantar Daji? Manyan Fa'idodin da Aka Bayyana

Man shafawa,wanda kuma aka sani da spermidine, wani sinadari ne na triamine polyamine wanda ake samu sosai a cikin shuke-shuke kamar alkama, waken soya, da dankali, ƙananan halittu kamar lactobacilli da bifidobacteria, da kuma nau'ikan kyallen dabbobi daban-daban. Spermidine wani hydrocarbon ne mai kwarangwal na carbon mai siffar zigzag wanda ya ƙunshi ƙwayoyin carbon guda 7 da ƙungiyoyin amino a duka ƙarshensu da kuma a tsakiya.

Binciken zamani ya tabbatar da cewa spermidine yana da hannu a cikin muhimman hanyoyin rayuwa kamar kwafi na DNA na ƙwayoyin halitta, kwafi na mRNA, da fassarar furotin, da kuma hanyoyin cututtuka da yawa kamar kariyar damuwa ta jiki da metabolism. Yana da kariya daga cututtukan zuciya da jijiyoyin jini, hana ƙari, da kuma daidaita kumburi, da sauransu. Muhimman ayyukan halittu.

Ana ɗaukar Spermidine a matsayin mai ƙarfi wajen kunna autophagy, wani tsari na sake amfani da ƙwayoyin halitta ta hanyar da tsofaffin ƙwayoyin halitta ke sabunta kansu da kuma sake samun aiki. Spermidine yana taka muhimmiyar rawa a cikin aikin ƙwayoyin halitta da kuma rayuwa. A cikin jiki, ana samar da spermidine daga putrescine, wanda hakan ke zama abin da ke gaba ga wani polyamine da ake kira spermine, wanda kuma yake da mahimmanci ga aikin ƙwayoyin halitta.

Spermidine da putrescine suna ƙarfafa autophagy, tsarin da ke wargaza sharar cikin ƙwayoyin halitta da kuma sake amfani da sassan ƙwayoyin halitta kuma hanya ce ta sarrafa inganci ga mitochondria, manyan ƙwayoyin halitta. Autophagy yana wargazawa kuma yana zubar da mitochondria da ya lalace ko ya lalace, kuma zubar da mitochondria tsari ne mai ƙarfi. Polyamines suna iya ɗaurewa da nau'ikan ƙwayoyin halitta daban-daban, wanda hakan ke sa su zama masu amfani. Suna tallafawa hanyoyin kamar girma tantanin halitta, kwanciyar hankali na DNA, yaduwar tantanin halitta, da apoptosis. Polyamines suna aiki kamar abubuwan da ke haifar da girma yayin rarrabuwar tantanin halitta, shi ya sa putrescine da spermidine suke da mahimmanci ga girma da aikin kyallen halitta.

Masu bincike sun yi nazarin yadda spermidine ke kare ƙwayoyin halitta daga damuwa ta oxidative, wadda za ta iya lalata ƙwayoyin halitta da kuma haifar da cututtuka daban-daban. Sun gano cewa spermidine yana kunna autophagy. Binciken ya gano wasu muhimman kwayoyin halitta da spermidine ke shafa waɗanda ke rage damuwa ta oxidative kuma suna haɓaka autophagy a cikin waɗannan ƙwayoyin. Bugu da ƙari, sun gano cewa toshe hanyar mTOR, wadda yawanci ke shiga cikin hana autophagy, ta ƙara inganta tasirin kariya na spermidine.

Waɗanne abinci ne ke ɗauke da sinadarin spermidine?

Spermidine muhimmin sinadarin polyamine ne. Baya ga samar da shi da jikin ɗan adam ya yi, wadataccen tushen abinci da ƙananan ƙwayoyin cuta na hanji suma manyan hanyoyin samar da shi ne. Yawan spermidine a cikin abinci daban-daban ya bambanta sosai, inda ƙwayar alkama sananniyar tushen shuka ce. Sauran hanyoyin abinci sun haɗa da innabi, kayayyakin waken soya, wake, masara, hatsi gaba ɗaya, chickpeas, wake, barkono kore, broccoli, lemu, shayi kore, shinkafa bran da barkono kore sabo. Bugu da ƙari, abinci kamar namomin kaza shiitake, tsaba amaranth, farin kabeji, cuku mai girma da durian suma suna ɗauke da spermidine.

Ya kamata a lura cewa abincin Bahar Rum ya ƙunshi abinci mai yawa mai yawan spermidine, wanda zai iya taimakawa wajen bayyana yanayin "blue zone" inda mutane ke rayuwa tsawon lokaci a wasu yankuna. Duk da haka, ga mutanen da ba za su iya cin isasshen spermidine ta hanyar abinci ba, ƙarin spermidine madadin tasiri ne. Spermidine da ke cikin waɗannan ƙarin abinci iri ɗaya ne da ke faruwa a zahiri, wanda hakan ya sa ya zama madadin da ya dace.

Menene putrescine?

Samar da putrescine ya ƙunshi hanyoyi biyu, waɗanda duka suna farawa da amino acid arginine. A cikin hanyar farko, da farko ana canza arginine zuwa agmatine wanda arginine decarboxylase ke haɓaka. Daga baya, ana ƙara canza agmatine zuwa N-carbamoylputrescine ta hanyar aikin agmatine iminohydroxylase. Daga ƙarshe, ana canza N-carbamoylputrescine zuwa putrescine, yana kammala tsarin canji. Hanya ta biyu tana da sauƙi, tana canza arginine kai tsaye zuwa ornithine, sannan ta canza ornithine zuwa putrescine ta hanyar aikin ornithine decarboxylase. Duk da cewa waɗannan hanyoyi biyu suna da matakai daban-daban, duka a ƙarshe suna cimma canjin daga arginine zuwa putrescine.

Putrescine wani sinadari ne na diamine wanda ake samu a cikin gabobin jiki daban-daban kamar pancreas, thymus, fata, kwakwalwa, mahaifa da kwai. Ana kuma samun Putrescine a cikin abinci kamar ƙwayar alkama, barkono kore, waken soya, pistachios, da lemu. Binciken da aka yi kwanan nan ya nuna cewa putrescine wani muhimmin sinadari ne na metabolism wanda zai iya hulɗa da macromolecules na halitta kamar su DNA mai karɓar ƙwayoyin cuta, RNA, ligands daban-daban (kamar β1 da β2 adrenergic receptors), da kuma sunadaran membrane, wanda ke haifar da jerin canje-canje na jiki ko na pathological a cikin jiki.

Tasirin maniyyi

Aikin hana tsufa: Spermidine yana da ƙarfi wajen hana tsufa kuma yana iya amsawa tare da free radicals don rage lalacewar oxidative ga ƙwayoyin halitta da free radicals ke haifarwa. A cikin jiki, spermidine kuma yana iya haɓaka bayyanar enzymes na antioxidant da haɓaka ƙarfin antioxidant.

Tsarin metabolism na makamashi: Spermidine yana da hannu wajen daidaita metabolism na makamashi na kwayoyin halitta, yana iya haɓaka sha da amfani da glucose bayan cin abinci, kuma yana shafar rabon metabolism na aerobic da metabolism na anaerobic ta hanyar daidaita ingancin samar da makamashi na mitochondria.

tasirin hana kumburi

Spermidine yana da tasirin hana kumburi kuma yana iya daidaita bayyanar abubuwan kumburi da rage faruwar kumburi na yau da kullun. Mafi mahimmanci yana da alaƙa da hanyar nukiliya factor-κB (NF-κB).

Girma, Ci gaba da kuma daidaita garkuwar jiki: Spermidine kuma yana taka muhimmiyar rawa wajen girma, ci gaba da kuma daidaita garkuwar jiki. Yana iya haɓaka fitar da hormone na girma a cikin jikin ɗan adam da kuma taimakawa wajen haɓaka kyallen jiki da gabobin jiki daban-daban. A lokaci guda, a cikin daidaita garkuwar jiki, spermidine yana ƙara juriyar jiki ga ƙwayoyin cuta da cututtuka ta hanyar daidaita samar da ƙwayoyin jini masu farin jini da kuma haɓaka cire nau'ikan iskar oxygen masu amsawa.

Jinkirin tsufa: Spermidine na iya haɓaka autophagy, wani tsari na tsaftacewa a cikin ƙwayoyin halitta wanda ke taimakawa wajen cire ƙwayoyin halitta da sunadarai da suka lalace, ta haka yana jinkirta tsufa.

Tsarin ƙwayoyin glial: Spermidine yana taka muhimmiyar rawa a cikin ƙwayoyin glial. Yana iya shiga cikin tsarin siginar tantanin halitta da haɗin aiki tsakanin ƙwayoyin jijiyoyi, kuma yana taka muhimmiyar rawa a cikin ci gaban jijiyoyi, watsawar synaptic, da juriya ga neuropathy.

Kariyar Zuciya da Jijiyoyin Jini: A fannin zuciya da jijiyoyin jini, spermidine na iya rage tarin kitse a cikin atherosclerotic plaques, rage hawan jini a zuciya, da kuma inganta aikin diastolic, ta haka ne ake samun kariya daga zuciya. Bugu da ƙari, shan spermidine a abinci yana inganta hawan jini kuma yana rage cututtukan zuciya da mutuwa.

A shekarar 2016, bincike da aka buga a mujallar Atherosclerosis ya tabbatar da cewa spermidine na iya rage tarin lipids a cikin plaques na atherosclerotic. A wannan shekarar, wani bincike da aka buga a mujallar Nature Medicine ya tabbatar da cewa spermidine na iya rage hawan jini a zuciya da kuma inganta aikin diastolic, ta haka ne ke kare zuciya da kuma tsawaita rayuwar beraye.

Inganta cutar Alzheimer

Shan kwayar halittar maniyyi yana da amfani ga aikin ƙwaƙwalwar ɗan adam. Ƙungiyar Farfesa Reinhart daga Ostiraliya ta gano cewa maganin maniyyi zai iya inganta aikin fahimi na tsofaffi. Binciken ya ɗauki tsarin makanta mai cibiya da yawa kuma ya yi rajistar tsofaffi 85 a gidajen kula da tsofaffi 6, waɗanda aka raba su zuwa ƙungiyoyi biyu ba zato ba tsammani kuma suka yi amfani da allurai daban-daban na maniyyi. An tantance aikin fahimi nasu ta hanyar gwaje-gwajen ƙwaƙwalwa kuma aka raba su zuwa ƙungiyoyi huɗu: babu ciwon hauka, ciwon hauka mai sauƙi, ciwon hauka mai matsakaici da ciwon hauka mai tsanani. An tattara samfuran jini don tantance yawan maniyyi a cikin jininsu. Sakamakon ya nuna cewa yawan maniyyi yana da alaƙa sosai da aikin fahimi a cikin rukunin marasa ciwon hauka, kuma matakin fahimi na tsofaffi masu ciwon hauka mai sauƙi zuwa matsakaici ya inganta sosai bayan sun sha manyan allurai na maniyyi.

Autophagy

Spermidine na iya haɓaka autophagy, kamar hanyar hana mTOR (maƙasudin rapamycin). Ta hanyar haɓaka autophagy, yana taimakawa wajen cire ƙwayoyin halitta da sunadarai da suka lalace a cikin ƙwayoyin halitta da kuma kula da lafiyar ƙwayoyin halitta.

Ana amfani da Spermidine hydrochloride a fannoni daban-daban

A fannin magunguna, ana amfani da spermidine hydrochloride a matsayin maganin hana hanta wanda zai iya inganta aikin hanta da kuma rage lalacewar hanta. Bugu da ƙari, ana iya amfani da spermidine hydrochloride don magance cututtuka kamar yawan cholesterol, hawan jini, da cututtukan zuciya da jijiyoyin jini.

Spermidine hydrochloride yana aiki ta hanyar rage matakan homocysteine ​​​​(Hcy) a cikin jini, ta haka yana rage haɗarin cututtukan zuciya da jijiyoyin jini. Nazarin ya nuna cewa spermidine hydrochloride na iya haɓaka metabolism na Hcy da rage haɗarin cututtukan zuciya da jijiyoyin jini ta hanyar rage matakan Hcy a cikin jini.

Wani bincike kan tasirin spermidine hydrochloride akan haɗarin cututtukan zuciya da jijiyoyin jini ya nuna cewa spermidine hydrochloride na iya rage matakan Hcy a cikin jini, ta haka rage haɗarin cututtukan zuciya da jijiyoyin jini. A cikin binciken, masu bincike sun raba mahalarta zuwa ƙungiyoyi biyu, ɗaya yana karɓar ƙarin spermidine hydrochloride ɗayan kuma yana karɓar placebo.

Sakamakon binciken ya nuna cewa mahalarta da suka karɓi ƙarin maganin spermidine hydrochloride suna da ƙarancin matakan Hcy a cikin jini da kuma raguwar haɗarin kamuwa da cututtukan zuciya da jijiyoyin jini. Bugu da ƙari, akwai wasu nazarce-nazarce da ke goyon bayan rawar da spermidine hydrochloride ke takawa wajen rage haɗarin kamuwa da cututtukan zuciya da jijiyoyin jini.

A fannin abinci, ana amfani da spermidine hydrochloride a matsayin mai ƙara ɗanɗano da kuma mai laushi don ƙara ɗanɗanon abinci da kuma kiyaye danshi na abinci. Bugu da ƙari, ana iya amfani da spermidine hydrochloride a matsayin ƙarin abinci don inganta yawan girma da ingancin tsoka na dabbobi.

A fannin kayan kwalliya, ana amfani da spermidine hydrochloride a matsayin mai humewa da kuma maganin hana tsufa don kiyaye danshi a fata da kuma rage lalacewar ƙwayoyin cuta. Bugu da ƙari, ana iya amfani da spermidine hydrochloride a cikin man shafawa na rana don rage lalacewar hasken ultraviolet a fata.

A fannin noma, ana amfani da spermidine hydrochloride a matsayin mai daidaita girman shuka don haɓaka girman amfanin gona da kuma ƙara yawan amfanin gona.