Lambar SLU-PP-332 CAS: 303760-60-3
Sigogin Samfura
| Sunan samfurin | SLU-PP-332 |
| Wani suna | SLU-PP-332； (E)-4-Hydroxy-N′(Naphthalen-2-Ylmethylene)Benzohydrazide;4-Hydroxybenzoic acid 2-(2-naphthalenylmethylene)hydrazide; |
| Lambar CAS | 303760-60-3 |
| Tsarin kwayoyin halitta | C18H14N2O2 |
| Nauyin kwayoyin halitta | 290.32 |
| Tsarkaka | kashi 98% |
| Bayyanar | Foda fari ko mara fari |
| shiryawa | 1kg/jaka, 25kg/ganga |
| Aikace-aikace | Kayan Abinci Mai Gina Jiki |
Gabatarwar samfur
SLU-PP-332 wani sabon sinadari ne na ƙananan ƙwayoyin halitta wanda ke aiki a matsayin mai hana karɓar estrogen na perifollicle (ERR), wanda galibi ke mai da hankali kan ERRα, ERRβ, da ERRγ, tare da tasirin kunnawa mafi ƙarfi akan ERRα (EC₅₀=98 nM). Wannan sinadari yana kunna hanyar siginar ERR ta hanyar kwaikwayon hanyoyin daidaita metabolism na motsa jiki, ta haka yana daidaita metabolism na makamashi, aikin mitochondrial, da juriyar tsoka.
Fasali
(1) Tsarin aiki: kunna ERRα/β/γ, haɓaka iskar shaka ta fatty acid (FAO) da kwayoyin halittar da ke da alaƙa da numfashi na mitochondrial, haɓaka rushewar kitse don samar da makamashi, rage tarin kitse, haɓaka aikin tsokar ƙashi na mitochondrial, inganta ƙarfin oxidative da juriya, kama da tasirin horon aerobic.
(2) Ayyukan halittu: a) Tasirin samfurin dabbobi: Beraye masu kiba: bayan kwana 28 na magani, nauyin jiki ya ragu da kashi 12%, kuma kitsen hanta, cholesterol, da triglycerides sun ragu sosai; beraye na yau da kullun: lokacin gudu ya karu da kashi 70%, nisan da ke tsakanin su ya karu da kashi 45%, ba tare da shafar ci ko motsi na son rai ba. b) Tsaro: babu wani mummunan sakamako da aka lura a cikin nazarin da aka yi kafin a fara aiki.
(3) Halayen jiki da sinadarai: fari zuwa fari mai ƙarfi, mai narkewa a cikin DMSO4 (75 mg/mL) da ethanol, ba ya narkewa a cikin ruwa; ya kamata a adana shi a cikin duhu.
Aikace-aikace
SLU-PP-332 yana cimma asarar kitse da daidaita glucose a cikin jini ta hanyar haɓaka iskar shaka da inganta yanayin insulin; yana inganta cututtukan hanta mai kitse marasa giya (NAFLD), yana rage yawan kitsen hanta; yana ba da tallafin metabolism ga mutanen da ba za su iya motsa jiki ba, yana kiyaye yawan tsoka da aikinsu; yana rage asarar tsoka yayin tsarin rage kitse; kuma yana da fa'idodi masu yawa a fannoni na rage kitse, haɓaka juriya, da haɓaka metabolism.
